Abraham, A., Jester, E.L.E., Granade, H.R., Plakas, S.M., Dickey, R.W., 2012. Caribbean ciguatoxin profile in raw and cooked fish implicated in ciguatera. Food Chem. 131, 192-198.

Adachi, R., Fukuyo, Y., 1979. The thecal structure of a toxic marine dinoflagellate Gambierdiscus toxicus gen. et spec. nov. collected in a ciguatera-endemic area. Bull. Jap. Soc. Sci. Fish. 45, 67-71.

Adams, M.J., 1993. AN OUTBREAK OF CIGUATERA POISONING IN A GROUP OF SCUBA-DIVERS. Journal of Wilderness Medicine 4, 304-311.

Adolf, J.E., Bachvaroff, T.R., Krupatkina, D.N., Nonogaki, H., Brown, P.J.P., Lewitus, A.J., Harvey, H.R., Place, A.R., 2006. Species specificity and potential roles of Karlodinium micrum toxin. Afr. J. Mar. Sci. 28, 415-419.

Adolf, J.E., Bachvaroff, T.R., Place, A.R., 2009. ENVIRONMENTAL MODULATION OF KARLOTOXIN LEVELS IN STRAINS OF THE COSMOPOLITAN DINOFLAGELLATE, KARLODINIUM VENEFICUM (DINOPHYCEAE). J. Phycol. 45, 176-192.

Ahmed, F.E., 1991. NATURALLY-OCCURRING SEAFOOD TOXINS. Journal of Toxicology-Toxin Reviews 10, 263-287.

Ahmed, F.E., 1992. REVIEW - ASSESSING AND MANAGING RISK DUE TO CONSUMPTION OF SEAFOOD CONTAMINATED WITH MICROORGANISMS, PARASITES, AND NATURAL TOXINS IN THE UNITED-STATES. International Journal of Food Science and Technology 27, 243-260.

Ahmed, F.E., 1993. ISSUES IN FISHERY PRODUCTS SAFETY IN THE UNITED-STATES. Environmental Toxicology and Water Quality 8, 141-152.

Ajuzie, C.C., 2008. Toxic Prorocentrum lima induces abnormal behaviour in juvenile sea bass. J. Appl. Phycol. 20, 19-27.

Akagi, H., Ohizumi, Y., Yasumoto, T., 1984. EFFECTS OF MAITOTOXIN ON SYMPATHETIC-GANGLIA OF RATS. Japanese Journal of Pharmacology 36, P251-P251.

Alfonso, A., Cabado, A.G., Vieytes, M.R., Botana, L.M., 2000. Functional compartments in rat mast cells for cAMP and calcium on histamine release. Cell. Signal. 12, 343-350.

Aligizaki, K., Nikolaidis, G., 2008. Morphological identification of two tropical dinoflagellates of the genera Gambierdiscus and Sinophysis in the Mediterranean Sea. J. Biol. Res. 9, 75-82.

Altamirano, R.C., Sierra-Beltrán, A.P., 2008. Biotoxins from freshwater and marine harmful algal blooms occurring in Mexico. Toxin Rev. 27, 27-77.

Alzola, E., Chaib, N., Pochet, S., Kabre, E., Marino, A., Dehaye, J.P., 2001. Modulation by propranolol of the uptake of ethidium bromide by rat submandibular acinar cells exposed to a P2X(7) agonist or to maitotoxin. Cell. Signal. 13, 465-473.

Amade, P., Mehiri, M., Lewis, R.J., 2014. Outstanding Marine Biotoxins: STX, TTX, and CTX, Outstanding Marine Molecules. Wiley-VCH Verlag GmbH & Co. KGaA, pp. 23-44.

Amano, T., Okita, Y., Yasumoto, T., Hoshi, M., 1993. MAITOTOXIN INDUCES ACROSOME REACTION AND HISTONE DEGRADATION OF STARFISH ASTERINA-PECTINIFERA SPERM. Zoological Science 10, 307-312.

Ami, E., Kishimoto, H., Ohrui, H., Meguro, H., 1997. Chiral synthesis of the BC-ring system of ciguatoxin from D-glucose. Biosci. Biotechnol. Biochem. 61, 2019-2024.

Aráoz, R., Molgó, J., Tandeau de Marsac, N., 2010. Neurotoxic cyanobacterial toxins. Toxicon 56, 813-828.

Arena, P., Levin, B., Fleming, L.E., Friedman, M.A., Blythe, D., 2004. A pilot study of the cognitive and psychological correlates of chronic ciguatera poisoning. Harmful Algae 3, 51-60.

Arnett, M.V., Lim, J.T., 2007. Ciguatera fish poisoning: Impact for the military health care provider. Milit. Med. 172, 1012-1015.

Asaeda, G., 2001. The transport of ciguatoxin: A case report. Journal of Emergency Medicine 20, 263-265.

Atkinson, R.C.J., Hope-Weeks, L.J., Mays, M.J., Solan, G.A., 2007. Medium size macrocycles incorporating combinations of coordinated-1,3-diyne units, oxygen donors and group 14 elements. J. Organomet. Chem. 692, 2076-2085.

Atsuta, H., Fujiwara, K., Murai, A., 1997. Diastereoselective synthesis of the GH ring part of ciguatoxin. Synlett, 307-&.

Au, N.P.B., 2016. Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury. Sci Rep 6, 26809.

Au, N.P.B., Kumar, G., Asthana, P., Tin, C., Mak, Y.L., Chan, L.L., Lam, P.K.S., Ma, C.H.E., 2016. Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury. Sci Rep 6.

Auvin, S., Pignol, B., Navet, E., Pons, D., Marin, J.G., Bigg, D., Chabrier, P.E., 2004. Novel dual inhibitors of calpain and lipid peroxidation. Bioorg. Med. Chem. Lett. 14, 3825-3828.

Azziz-Baumgartner, E., Luber, G., Conklin, L., Tosteson, T.R., Granade, H.R., Dickey, R.W., Backer, L.C., 2012. Assessing the Incidence of Ciguatera Fish Poisoning with Two Surveys Conducted in Culebra, Puerto Rico, during 2005 and 2006. Environ. Health Perspect. 120, 526-529.

Baba, T., Huang, G., Isobe, M., 2003. Synthesis of the JKLM-ring fragment of ciguatoxin. Tetrahedron 59, 6851-6872.

Baba, T., Isobe, M., 2003. Synthesis of JKLM ring fragment of ciguatoxin via acetylene-cobalt strategy. Synlett, 547-551.

Baba, T., Takai, S., Sawada, N., Isobe, M., 2004. Stereoselective synthesis of the fully functionalized HIJ-ring framework of ciguatoxin. Synlett, 603-608.

Babinchak, J.A., Doucette, G.J., Ball, R.M., 1995. Partial characterization of the LSU rRNA gene from the ciguatoxic dinoflagellate, Gambierdiscus toxicus.

Babinchak, J.A., Moeller, P.D.R., Van Dolah, F.M., Eyo, P.B., Ramsdell, J.S., 1994. Production of ciguatoxins in cultured Gambierdiscus toxicus. Memoirs of the Queenland Museaum [Mem. Queensl. Mus.] 34, 447-453.

Bachvaroff, T.R., Adolf, J.E., Place, A.R., 2009. STRAIN VARIATION IN KARLODINIUM VENEFICUM (DINOPHYCEAE): TOXIN PROFILES, PIGMENTS, AND GROWTH CHARACTERISTICS. J. Phycol. 45, 137-153.

Bachvaroff, T.R., Adolf, J.E., Squier, A.H., Harvey, H.R., Place, A.R., 2008. Characterization and quantification of karlotoxins by liquid chromatography-mass spectrometry. Harmful Algae 7, 473-484.

Bagnis, R., Bennett, J., Prieur, C., Legrand, A.M., 1985. The dynamics of three toxic benthic dinoflagellates and the toxicity of ciguateric surgeonfish in French Polynesia, in: Anderson, D.M., White, A.W., Baden, D.G. (Eds.), Toxic Dinoflagellates. Elsevier, New York, NY, pp. 177-182.

Bagnis, R., Chanteau, S., Chungue, E., Hurtel, J.M., Yasumoto, T., Inoue, A., 1980. ORIGINS OF CIGUATERA FISH POISONING - A NEW DINOFLAGELLATE, GAMBIERDISCUS-TOXICUS ADACHI AND FUKUYO, DEFINITIVELY INVOLVED AS A CAUSAL AGENT. Toxicon 18, 199-208.

Bagnis, R., Hurtel, J.M., Chanteau, S., Chungue, E., Inoue, A., Yasumoto, T., 1979. DINOFLAGELLAE GAMBIERDISCUS-TOXICUS ADACHI ET FUKUYO - PROBABLE CAUSE OF CIGUATERA. Comptes Rendus Hebdomadaires Des Seances De L Academie Des Sciences Serie D 289, 671-674.

Bai, X.M., Adolf, J.E., Bachvaroff, T., Place, A.R., Coats, D.W., 2007. The interplay between host toxins and parasitism by Amoebophrya. Harmful Algae 6, 670-678.

Baig, H.S., Saifullah, S.M., Dar, A., 2006. Occurrence and toxicity of Amphidinium carterae Hulburt in the North Arabian Sea. Harmful Algae 5, 133-140.

Banaigs, B., Institut, O., 2004. Marine organisms and secondary metabolites: from chemical ecology to pharmacology, Substances Marines a Visee Therapeutique, pp. 423-448.

Barton, E.D., Tanner, P., Turchen, S.G., Tunget, C.L., Manoguerra, A., Clark, R.F., 1995. CIGUATERA FISH POISONING - A SOUTHERN CALIFORNIA EPIDEMIC. Western Journal of Medicine 163, 31-35.

Baumann, F., Bourrat, M.-B., Pauillac, S., 2010. Prevalence, symptoms and chronicity of ciguatera in New Caledonia: Results from an adult population survey conducted in Noumea during 2005. Toxicon 56, 662-667.

Baumgold, J., Paek, R., Yasumoto, T., 1992. AGENTS THAT STIMULATE PHOSPHOINOSITIDE TURNOVER ALSO ELEVATE CAMP IN SK-N-SH HUMAN NEUROBLASTOMA-CELLS. Life Sci. 50, 1755-1759.

Bavastrelli, M., Bertucci, P., Midulla, M., Giardini, O., Sanguigni, S., 2001. Ciguatera fish poisoning: an emerging syndrome in Italian travelers. Journal of Travel Medicine 8, 139-142.

Baylet, R., Beccaria, C., Niaussat, P.M., Boyer, F., Gillaud, M., 1978. FOOD POISONING BY CIGUATOXIN IN FRANCE. Pathologie Biologie 26, 95-97.

Beadle, A., 1997. Ciguatera fish poisoning. Milit. Med. 162, 319-322.

Becker, S., Prusaksochaczewski, E., Zamponi, G., Becksickinger, A.G., Gordon, R.D., French, R.J., 1992. ACTION OF DERIVATIVES OF MU-CONOTOXIN-GIIIA ON SODIUM-CHANNELS - SINGLE AMINO-ACID SUBSTITUTIONS IN THE TOXIN SEPARATELY AFFECT ASSOCIATION AND DISSOCIATION RATES. Biochemistry 31, 8229-8238.

Begier, E.M., Backer, L.C., Weisman, R.S., Hammond, R.M., Fleming, L.E., Blythe, D., 2006. Outbreak bias in illness reporting and case confirmation in ciguatera fish poisoning surveillance in south Florida. Public Health Rep. 121, 658-665.

Bennasar, M.L., Roca, T., Monerris, M., Garcia-Diaz, D., 2006. Sequential N-acylamide methylenation-enamide ring-closing metathesis: Construction of benzo-fused nitrogen heterocycles. J. Org. Chem. 71, 7028-7034.

Benoit, E., Juzans, P., Legrand, A.M., Molgo, J., 1996. Nodal swelling produced by ciguatoxin-induced selective activation of sodium channels in myelinated nerve fibers. Neuroscience 71, 1121-1131.

Benoit, E., Laurent, D., Mattei, C., Legrand, A.M., Molgo, J., 2000. Reversal of Pacific ciguatoxin-1B effects on myelinated axons by agents used in ciguatera treatment, 1st Ichtyological Conference in France, RIF 2000, Paris, France, pp. 33-40.

Benoit, E., Legrand, A.M., Dubois, J.M., 1986. EFFECTS OF CIGUATOXIN ON CURRENT AND VOLTAGE CLAMPED FROG MYELINATED NERVE-FIBER. Toxicon 24, 357-364.

Benoit, E., Mattei, C., Legrand, A.M., Molgo, J., 1997. Ionic basis of the neurocellular actions of pacific ciguatoxins implicated in ciguatera fish poisoning, in: Seret, B., Sire, J.Y. (Eds.), 5th Indo-Pacific Fish Conference, Noumea, New Caledonia, pp. 745-758.

Benoit, E., Mattei, C., Ouanounou, G., Meunier, F.A., Suput, D., Le Gall, F., Marquais, M., Dechraoui, M.Y., Molgo, J., 2002. Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins, Conference on Liposomes: from Models to Applications, Wroclaw, Poland, pp. 317-321.

Bentur, Y., Spanier, E., 2007. Ciguatoxin-like substances in edible fish on the eastern Mediterranean. Clin. Toxicol. 45, 695-700.

Berger, J.A., Berger, L.R., 1979. Studies to develope a colorometric ELISA test to assay ciguatoxin in fish tissue. Revue Internationale d'Oceanographie Medicale [Rev. Intern. Océanog. Méd.] 53-54, 23-32.

Bergmann, J.S., Alam, M., 1981. ON THE TOXICITY OF THE CIGUATERA PRODUCING DINOFLAGELLATE, GAMBIERDISCUS-TOXICUS ADACHI AND FUKUYO ISOLATED FROM THE FLORIDA KEYS. Journal of Environmental Science and Health Part a-Environmental Science and Engineering & Toxic and Hazardous Substance Control 16, 493-500.

Bergmann, J.S., Nechay, B.R., 1982. MAITOTOXIN INHIBITS NA+ + K+ ATPASE INVITRO. Federation Proceedings 41, 1562-1562.

Bernard, V., Laurent, A., Derancourt, J., Clementdurand, M., Picard, A., Lepeuch, C., Berta, P., Doree, M., 1988. MAITOTOXIN TRIGGERS THE CORTICAL REACTION AND PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE BREAKDOWN IN AMPHIBIAN OOCYTES. European Journal of Biochemistry 174, 655-662.

Berreurbonnenfant, J., Ammar, M., Dubreuil, A., Kiefer, H., Diogene, G., Metezeau, P., Puiseuxdao, S., 1994. MODULATION OF FIBROBLAST RESPONSE TO MAITOTOXIN ALONG THE CELL-DIVISION CYCLE. Cell Biol. Toxicol. 10, 423-427.

Berta, P., Phaneuf, S., Derancourt, J., Casanova, J., Durandclement, M., Lepeuch, C., Haiech, J., Cavadore, J.C., 1988. THE EFFECTS OF MAITOTOXIN ON PHOSPHOINOSITIDES AND CALCIUM-METABOLISM IN A PRIMARY CULTURE OF AORTIC SMOOTH-MUSCLE CELLS. Toxicon 26, 133-141.

Berta, P., Sladeczek, F., Derancourt, J., Durand, M., Travo, P., Haiech, J., 1986. MAITOTOXIN STIMULATES THE FORMATION OF INOSITOL PHOSPHATES IN RAT AORTIC MYOCYTES. FEBS Lett. 197, 349-352.

Betancor, C., Dorta, R.L., Freire, R., Prange, T., Suarez, E., 2000. Rearrangement of spiroacetals of the 1,6-dioxaspiro 4.5 decan-10-yl methanesulfonate type. Synthesis of cis-fused 1,6-dioxadecalins. J. Org. Chem. 65, 8822-8825.

Betancort, J.M., Martin, T., Palazon, J.M., Martin, V.S., 2003. Stereoselective synthesis of cyclic ethers by intramolecular trapping of dicobalt hexacarbonyl-stabilized propargylic cations. J. Org. Chem. 68, 3216-3224.

Bhakuni, D.S., Rawat, D.S., 2005. Bioactive marine toxins, Bioactive marine natural products. pp. 151-207. 2005.

Bidard, J.N., Vijverberg, H.P.M., Frelin, C., Chungue, E., Legrand, A.M., Bagnis, R., Lazdunski, M., 1984. CIGUATOXIN IS A NOVEL TYPE OF NA+ CHANNEL TOXIN. J. Biol. Chem. 259, 8353-8357.

Bidard, J.-N., Vijverbergs, H.P.M., Frelin, C., Chungue, E., Legrand, A.-M., Bagnis, R., Lazdunski, M., 1984. Ciguatoxin is a novel type of Na+ channel toxin. Journal of Biological Chemistry [J. Biol. Chem.] 259, 8353-8357.

Bielfeld-Ackermann, A., Range, C., Korbmacher, C., 1998. Maitotoxin (MTX) activates a nonselective cation channel in Xenopus laevis oocytes. Pflugers Arch. 436, 329-337.

Bienfang, P., Oben, B., DeFelice, S., Moeller, P., Huncik, K., Oben, P., Toonen, R., Daly-Engel, T., Bowen, B., 2008. Ciguatera: the detection of neurotoxins in carnivorous reef fish from the coast of Cameroon, West Africa. Afr. J. Mar. Sci. 30, 533-540.

Bienfang, P.K., Defelice, S.V., Laws, E.A., Brand, L.E., Bidigare, R.R., Christensen, S., Trapido-Rosenthal, H., Hemscheidt, T.K., McGillicuddy, D.J., Anderson, D.M., Solo-Gabriele, H.M., Boehm, A.B., Backer, L.C., 2011. Prominent human health impacts from several marine microbes: history, ecology, and public health implications. Int J Microbiol 2011, 152815.

Bignami, G.S., Waller, D.F., Yasumoto, T., 1995. Antibodies to maitotoxin elicited by immunization with toxin-fragment conjugates, Proceedings of the Fifth Pan American Symposium on Animal Plant and Microbial Toxins, Frederick, Md, pp. 1393-1397.

Bignami, G.S., Waller, D.F., Yasumoto, T., 1996. Antibodies to maitotoxin elicited by immunization with toxin-fragment conjugates. Toxicon 34, 1393-1397.

Bircher, A., Schaub, N., Scherer, K., 2005. The catch of the day: Scombrotoxin and anisakis simplex as cause of allergy-like disorders. Allergologie 28, 330-337.

Birinyi Strachan, L.C., Gunning, S.J., Lewis, R.J., Nicholson, G.M., 2005. Block of voltage-gated potassium channels by Pacific ciguatoxin-1 contributes to increased neuronal excitability in rat sensory neurons. Toxicol. Appl. Pharmacol. 204, 175-186.

Birinyi-Strachan, L.C., Davies, M.J., Lewis, R.J., Nicholson, G.M., 2005. Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: A comparison with other osmotic agents and free radical scavengers. Neuropharmacology 49, 669-686.

Bizsel, N., Bizsel, K.C., 2002. New records of toxic algae Heterosigma cf. akashiwo and Gymnodinium cf. mikimotoi in the hypereutrophic Izmir Bay (Aegean Sea): Coupling between organisms and water quality parameters. Isr. J. Plant Sci. 50, 33-44.

Blackstone, G.M., Nordstrom, J.L., Bowen, M.D., Meyer, R.F., Imbro, P., DePaola, A., 2007. Use of a real time PCR assay for detection of the ctxA gene of vibrio cholerae in an environmental survey of Mobile Bay. J. Microbiol. Methods 68, 254-259.

Bloomquist, J.R., 2003. Mode of action of atracotoxin at central and peripheral synapses of insects. Invertebrate Neuroscience 5, 45-50.

Blume, C., Rapp, M., Rath, J., Koller, H., Arendt, G., Bach, D., Grabensee, B., 1999. Ciguatera intoxication - Growing importance for differential diagnosis in an area of long distance tourism. Medizinische Klinik 94, 45-49.

Boada, L.D., Zumbado, M., Luzardo, O.P., Almeida-Gonzalez, M., Plakas, S.M., Granade, H.R., Abraham, A., Jester, E.L., Dickey, R.W., 2010. Ciguatera fish poisoning on the West Africa Coast: An emerging risk in the Canary Islands (Spain). Toxicon 56, 1516-1519.

Boada, L.D., Zumbado, M., Luzardo, O.R., Almeida-González, M., Plakas, S.M., Granade, H.R., Abraham, A., Jester, E.L.E., Dickey, R.W., 2010. Ciguatera fish poisoning on the West Africa Coast: An emerging risk in the Canary Islands (Spain). Toxicon 56, 1516-1519.

Boisier, P., Ranaivoson, G., Rasolofonirina, N., Andriamahefazafy, B., Roux, J., Chanteau, S., Satake, M., Yasumoto, T., 1995. FATAL MASS POISONING IN MADAGASCAR FOLLOWING INGESTION OF A SHARK (CARCHARHINUS-LEUCAS) - CLINICAL AND EPIDEMIOLOGIC ASPECTS AND ISOLATION OF TOXINS. Toxicon 33, 1359-1364.

Bomber, J.W., Aikman, K.E., 1988

1989. The ciguatera dinoflagellates. Biological Oceanography [ Biol. Oceanogr.] 6, 291-311.

Bomber, J.W., Aikman, K.E., 1989. The ciguatera dinoflagellates. Biological Oceanography [Biol. Oceanogr.] 6, 291-311.

Bomber, J.W., Guillard, R.R.L., Nelson, W.G., 1988. ROLES OF TEMPERATURE, SALINITY, AND LIGHT IN SEASONALITY, GROWTH, AND TOXICITY OF CIGUATERA-CAUSING GAMBIERDISCUS-TOXICUS ADACHI ET FUKUYO (DINOPHYCEAE). J. Exp. Mar. Biol. Ecol. 115, 53-65.

Bomber, J.W., Morton, S.L., J.A., B., Norris, D.R., Morton, J.G., 1988. Epiphytic dinoflagellates of drift algae - Another toxigenic community in the ciguatera food chain. Bulletin of Marine Science [Bull. Mar. Sci.] 43, 204-214.

Bomber, J.W., Norris, D.R., Mitchell, L.E., 1990. Benthic dinoflagellates associated with ciguatera from the Florida Keys. II. Temporal, spatial and substrate heterogeneity of Prorocentrum lima, in: Granéli, E., Sundstrom, B., Edler, L., Anderson, D.M. (Eds.), Toxic Marine Phytoplankton. Elsevier, New York, pp. 45-50.

Bomber, J.W., Rubio, M.G., Norris, D.R., 1989. Epiphytism of dinoflagellates associated with the disease ciguatera: substrate specificity and nutrition. Phycologia [Phycologia] 28, 360-368.

Bomber, J.W., Tindall, D.R., 1988. GENETIC-VARIABILITY IN ACCLIMATED CELL TOXICITIES AMONG ATLANTIC AND PACIFIC CLONES OF THE CIGUATERA-CAUSING DINOFLAGELLATE GAMBIERDISCUS-TOXICUS. Faseb J. 2, A375-A375.

Bond, S., Perlmutter, P., 2000. The vitamin C route to the ciguatoxins: enantioselective synthesis of a ring F building block. Chem. Commun., 567-568.

Bond, S., Perlmutter, P., 2002. Synthesis of a ring F building block for the ciguatoxins. Tetrahedron 58, 1779-1787.

Botana, L.M., 2012. A perspective on the toxicology of marine toxins. Chem. Res. Toxicol. 25, 1800-1804.

Bottein Dechraoui, M.-Y., 2008. Repeat exposure to ciguatoxin leads to enhanced and sustained. Toxicology 246, 55-62.

Bottein, M.Y.D., Kashinsky, L., Wang, Z.H., Littnan, C., Ramsdell, J.S., 2011. Identification of Ciguatoxins in Hawaiian Monk Seals Monachus schauinslandi from the Northwestern and Main Hawaiian Islands. Environ. Sci. Technol. 45, 5403-5409.

Bottein, M.-Y.D., Kashinsky, L., Wang, Z., Littnan, C., Ramsdell, J.S., 2011. Identification of Ciguatoxins in Hawaiian Monk Seals Monachus schauinslandi from the Northwestern and Main Hawaiian Islands. Environ. Sci. Technol. 45, 5403-5409.

Bottein, M.-Y.D., Wang, Z., Ramsdell, J.S., 2011. Toxicokinetics of the ciguatoxin P-CTX-1 in rats after intraperitoneal or oral administration. Toxicology 284, 1-6.

Bouaicha, N., Ammar, M., Hennion, M.C., Sandra, P., 1997. A new method for determination of maitotoxin by capillary zone electrophoresis with ultraviolet detection. Toxicon 35, 955-962.

Boudreau, P., Durand-Clement, M., Ammar, M., Fessard, V., 1995. Ecological and toxicological characteristics of benthic dinoflagellates in a ciguateric area (Saint Barthelemy: French Indies) in: Lassus, P., Arzul, G., Erard, E., Gentien, P., Marcaillou, C. (Eds.), Harmful Marine Algal Blooms. Lavoisier, Intercept Ltd., Paris, pp. 133-137.

Bourdeau, P., Bagnis, R., 1989. Risk factors of ciguatera in the French West Indies in Saint-Barthelemy, Saint-Martin and Anguilla. Revue d'elevage et de medecine veterinaire des pays tropicaux 42, 393-410.

Bourdeau, P., Durand, C.M., Ammar, M., Fessard, V., 1995. : Ecological and toxicological characteristics of benthic dinoflagellates in a ciguateric area (Saint Barthelemy: French West Indies). : HARMFUL MARINE ALGAL BLOOMS.#PROLIFERATION D' ALGUES MARINES NUISIBLES. Lassus, P., 133-137.

Bourdy, G., Cabalion, P., Amade, P., Laurent, D., 1992. TRADITIONAL REMEDIES USED IN THE WESTERN PACIFIC FOR THE TREATMENT OF CIGUATERA POISONING. Journal of Ethnopharmacology 36, 163-174.

BouzBouz, S., Cossy, J., 2001. Chemoselective cross-metathesis reaction. Application to the synthesis of the C1-C14 fragment of amphidinol 3. Org. Lett. 3, 1451-1454.

Boydron-Le Garrec, R., Benoit, E., Sauviat, M.-P., Lewis, R.J., Molgó, J., Laurent, D., 2005. Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators. Toxicon 46, 625-634.

Braidy, N., Matin, A., Rossi, F., Chinain, M., Laurent, D., Guillemin, G.J., 2014. Neuroprotective effects of rosmarinic acid on ciguatoxin in primary human neurons. Neurotox Res 25, 226-234.

Brereton, H.M., Chen, J.L., Rychkov, G., Harland, M.L., Barritt, G.J., 2001. Maitotoxin activates an endogenous non-selective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells. Biochim. Biophys. Acta-Mol. Cell Res. 1540, 107-126.

Brereton, H.M., Harland, M.L., Auld, A.M., Barritt, G.J., 2000. Evidence that the TRP-1 protein is unlikely to account for store-operated Ca2+ inflow in Xenopus laevis oocytes. Mol. Cell. Biochem. 214, 63-74.

Bressler, J., Forman, S., Goldstein, G.W., 1994. PHOSPHOLIPID-METABOLISM IN NEURAL MICROVASCULAR ENDOTHELIAL-CELLS AFTER EXPOSURE TO LEAD IN-VITRO. Toxicol. Appl. Pharmacol. 126, 352-360.

Bressler, J.P., Belloniolivi, L., Forman, S., 1994. EFFECT OF GANGLIOSIDE GM1 ON ARACHIDONIC-ACID RELEASE IN BOVINE AORTIC ENDOTHELIAL-CELLS. Life Sci. 54, 49-60.

Brett, M.M., 2003. Food poisoning associated with biotoxins in fish and shellfish. Current Opinion in Infectious Diseases 16, 461-465.

Brock, J.A., McLachlan, E.M., Jobling, P., Lewis, R.J., 1995. ELECTRICAL-ACTIVITY IN RAT TAIL ARTERY DURING ASYNCHRONOUS ACTIVATION OF POSTGANGLIONIC NERVE-TERMINALS BY CIGUATOXIN-1. Br. J. Pharmacol. 116, 2213-2220.

Brock, J.A., McLachlan, E.M., Rayner, S.E., 1997. Contribution of alpha-adrenoceptors to depolarization and contraction evoked by continuous asynchronous sympathetic nerve activity in rat tail artery. Br. J. Pharmacol. 120, 1513-1521.

Burk, C., Usleber, E., Martlbauer, E., 1998. Intoxications through marine algae toxins - a review. Arch. Lebensm.hyg. 49, 16-20.

Burns, P.D., Hayes, S.H., Silvia, W.J., 1998. Cellular mechanisms by which oxytocin mediates uterine prostaglandin F-2 alpha synthesis in bovine endometrium: Role of calcium. Domestic Animal Endocrinology 15, 477-487.

Butera, R., Prockop, L.D., Buonocore, M., Locatelli, C., Gandini, C., Manzo, L., 2000. Mild ciguatera poisoning: Case reports with neurophysiological evaluations. Muscle Nerve 23, 1598-1603.

Cagide, E., Louzao, M.C., Espina, B., Ares, I.R., Vieytes, M.R., Sasaki, M., Fuwa, H., Tsukano, C., Konno, Y., Yotsu-Yamashita, M., Paquette, L.A., Yasumoto, T., Botana, L.M., 2011. Comparative Cytotoxicity of Gambierol versus Other Marine Neurotoxins. Chem. Res. Toxicol. 24, 835-842.

Cai, M.Y., Qu, X.M., 1998. Synthesis and expression of omega-conotoxin MVIIA, in: Hu, X.Y., Wang, R., Tam, J.P. (Eds.), 5th Chinese Peptide Symposium, Lanzhou, Peoples R China, pp. 129-133.

Caillaud, A., Canete, E., de la Iglesia, P., Gimenez, G., Diogene, J., 2009. Cell-based assay coupled with chromatographic fractioning: A strategy for marine toxins detection in natural samples. Toxicol. Vitro 23, 1591-1596.

Caillaud, A., de la Iglesia, P., Barber, E., Eixarch, H., Mohammad-Noor, N., Yasumoto, T., Diogene, J., 2011. Monitoring of dissolved ciguatoxin and maitotoxin using solid-phase adsorption toxin tracking devices: Application to Gambierdiscus pacificus in culture. Harmful Algae 10, 433-446.

Caillaud, A., de la Iglesia, P., Barber, E., Eixarch, H., Mohammad-Noor, N., Yasumoto, T., Diogène, J., 2011. Monitoring of dissolved ciguatoxin and maitotoxin using solid-phase adsorption toxin tracking devices: Application to Gambierdiscus pacificus in culture. Harmful Algae 10, 433-446.

Caillaud, A., de la Iglesia, P., Darius, H.T., Pauillac, S., Aligizaki, K., Fraga, S., Chinain, M., Diogene, J., 2010. Update on Methodologies Available for Ciguatoxin Determination: Perspectives to Confront the Onset of Ciguatera Fish Poisoning in Europe. Mar. Drugs 8, 1838-1907.

Caillaud, A., Eixarch, H., de la Iglesia, P., Rodriguez, M., Dominguez, L., Andree, K.B., Diogene, J., 2012. Towards the standardisation of the neuroblastoma (neuro-2a) cell-based assay for ciguatoxin-like toxicity detection in fish: application to fish caught in the Canary Islands. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 29, 1000-1010.

Caillaud, A., Eixarch, H., de la Iglesia, P., Rodriguez, M., Dominguez, L., Andree, K.B., Diogène, J., 2012. Towards the standardisation of the neuroblastoma (neuro-2a) cell-based assay for ciguatoxin-like toxicity detection in fish: application to fish caught in the Canary Islands. Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment 29, 1000-1010.

Camacho, F.G., Rodriguez, J.G., Miron, A.S., Garcia, M.C.C., Belarbi, E.H., Chisti, Y., Grima, E.M., 2007. Biotechnological significance of toxic marine dinoflagellates. Biotechnol. Adv. 25, 176-194.

Cameron, J., Capra, M.F., 1993. THE BASIS OF THE PARADOXICAL DISTURBANCE OF TEMPERATURE PERCEPTION IN CIGUATERA POISONING. Journal of Toxicology-Clinical Toxicology 31, 571-579.

Cameron, J., Flowers, A.E., Capra, M.F., 1991. EFFECTS OF CIGUATOXIN ON NERVE EXCITABILITY IN RATS .1. J. Neurol. Sci. 101, 87-92.

Cameron, J., Flowers, A.E., Capra, M.F., 1991. ELECTROPHYSIOLOGICAL STUDIES ON CIGUATERA POISONING IN MAN .2. J. Neurol. Sci. 101, 93-97.

Cameron, J., Flowers, A.E., Capra, M.F., 1993. MODIFICATION OF THE PERIPHERAL-NERVE DISTURBANCE IN CIGUATERA POISONING IN RATS WITH LIDOCAINE. Muscle Nerve 16, 782-786.

Campi, E.M., Eriksson, L.K., Guy, S.T., Jackson, W.R., Perlmutter, P., 1999. Carbonylation approaches to oxygen heterocyclic compounds. Journal of Molecular Catalysis a-Chemical 143, 243-252.

Campora, C.E., Dierking, J., Tamaru, C.S., Hokama, Y., Vincent, D., 2008. Detection of ciguatoxin in fish tissue using sandwich ELISA and neuroblastoma cell bioassay. J. Clin. Lab. Anal. 22, 246-253.

Campora, C.E., Hokama, Y., Ebesu, J.S.M., 2006. Comparative analysis of purified pacific and Caribbean ciguatoxin congeners and related marine toxins using a modified ELISA technique. J. Clin. Lab. Anal. 20, 121-125.

Campora, C.E., Hokama, Y., Tamaru, C.S., Anderson, B., Vincent, D., 2010. Evaluating the Risk of Ciguatera Fish Poisoning from Reef Fish Grown at Marine Aquaculture Facilities in Hawai'i. J. World Aquacult. Soc. 41, 61-70.

Campora, C.E., Hokama, Y., Yabusaki, K., Isobe, M., 2008. Development of an enzyme-linked immunosorbent assay for the detection of ciguatoxin in fish tissue using chicken immunoglobulin Y. J. Clin. Lab. Anal. 22, 239-245.

Candenas, M.L., Pinto, F.M., Cintado, C.G., Morales, E.Q., Brouard, I., Diaz, M.T., Rico, M., Rodriguez, E., Rodriguez, R.M., Perez, R., Perez, R.L., Martin, J.D., 2002. Synthesis and biological studies of flexible brevetoxin/ciguatoxin models with marked conformational preference. Tetrahedron 58, 1921-1942.

Canete, E., Campas, M., de la Iglesia, P., Diogene, J., 2010. NG108-15 cell-based and protein phosphatase inhibition assays as alternative semiquantitative tools for the screening of lipophilic toxins in mussels. Okadaic acid detection. Toxicol. Vitro 24, 611-619.

Canete, E., Diogene, J., 2010. Improvements in the use of neuroblastoma x glioma hybrid cells (NG108-15) for the toxic effect quantification of marine toxins. Toxicon 55, 381-389.

Cankurtaran-Sayar, S., Sayar, K., Ugur, M., 2009. P2X7 Receptor Activates Multiple Selective Dye-Permeation Pathways in RAW 264.7 and Human Embryonic Kidney 293 Cells. Mol. Pharmacol. 76, 1323-1332.

Capra, M.F., Flowers, A.E., Cameron, J., 1988. THE EFFECT OF CIGUATOXIN ON THE RATE OF NA+ EFFLUX IN UNMYELINATED OLFACTORY NERVES OF TELEOSTS. Toxicon 26, 17-18.

Capra, M.F., Hahn, S.T., 1992. The cyanobacterium Oscillatoria erythraea-a potential source of toxin in the ciguatera food-chain. Food Additives & Contaminants 9, 351.

Carballeira, N.M., Emiliano, A., Sostre, A., Restituyo, J.A., Gonzalez, I.M., Colon, G.M., Tosteson, C.G., Tosteson, T.R., 1998. Fatty acid composition of bacteria associated with the toxic dinoflagellate Ostreopsis lenticularis and with Caribbean Palythoa species. Lipids 33, 627-632.

Carlson, R.D., 1985. : Distribution, periodicity, and culture of benthic/epiphytic dinoflagellates in a ciguatera endemic region of the Caribbean. : DISS. ABST. INT. PT. B SCI. and ENG 46.

Cataldi, M., Secondo, A., D'Alessio, A., Taglialatela, M., Hofmann, F., Klugbauer, N., Di Renzo, G., Annunziato, L., 1999. Studies on maitotoxin-induced intracellular Ca2+ elevation in Chinese hamster ovary cells stably transfected with cDNAs encoding for L-type Ca2+ channel subunits. J. Pharmacol. Exp. Ther. 290, 725-730.

Centers for Disease, C., Prevention, 2009. Cluster of ciguatera fish poisoning--North Carolina, 2007. MMWR. Morbidity and mortality weekly report 58, 283-285.

Centers for Disease, C., Prevention, 2013. Ciguatera fish poisoning - New York City, 2010-2011. MMWR. Morbidity and mortality weekly report 62, 61-65.

Chahine, M., Chen, L.Q., Fotouhi, N., Walsky, R., Fry, D., Santarelli, V., Horn, R., Kallen, R.G., 1995. Characterizing the mu-conotoxin binding site on voltage-sensitive sodium channels with toxin analogs and channel mutations. Receptors & Channels 3, 161-174.

Chahine, M., Sirois, J., Marcotte, P., Chen, L.Q., Kallen, R.G., 1998. Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site. Biophys. J. 75, 236-246.

Chaiyanan, S., Huq, A., Maugel, T., Colwell, R.R., 2001. Viability of the Nonculturable Vibrio cholerae O1 and O139. Syst. Appl. Microbiol. 24, 331-341.

Chan, T., 2015. Emergence and Epidemiology of Ciguatera in the Coastal Cities of Southern China. Mar. Drugs 13, 1175-1184.

Chan, T.Y., 2014. Epidemiology and clinical features of ciguatera fish poisoning in Hong Kong. Toxins (Basel) 6, 2989-2997.

Chan, T.Y.K., 1998. Childhood poisoning: The scope for prevention. Veterinary and Human Toxicology 40, 361-363.

Chan, T.Y.K., 1998. Lengthy persistence of ciguatoxin in the body. Transactions of the Royal Society of Tropical Medicine and Hygiene 92, 662-662.

Chan, T.Y.K., 2013. Ciguatera caused by consumption of humphead wrasse. Toxicon 76, 255-259.

Chan, T.Y.K., 2013. Severe bradycardia and prolonged hypotension in ciguatera. Singapore Medical Journal 54, e120-e122.

Chan, T.Y.K., 2014. Epidemiology and Clinical Features of Ciguatera Fish Poisoning in Hong Kong. Toxins 6, 2989-2997.

Chan, T.Y.K., 2014. Large outbreaks of ciguatera after consumption of brown marbled grouper. Toxins 6, 2041-2049.

Chan, T.Y.K., 2015. Ciguatera Fish Poisoning in East Asia and Southeast Asia. Mar. Drugs 13, 3466-3478.

Chan, T.Y.K., 2016. Characteristic Features and Contributory Factors in Fatal Ciguatera Fish Poisoning-Implications for Prevention and Public Education. The American journal of tropical medicine and hygiene 94, 704-709.

Chan, T.Y.K., Kwok, T.C.Y., 2001. Chronicity of neurological features in ciguatera fish poisoning. Hum. Exp. Toxicol. 20, 426-428.

Chan, W.H., Mak, Y.L., Wu, J.J., Jin, L., Sit, W.H., Lam, J.C.W., de Mitcheson, Y.S., Chan, L.L., Lam, P.K.S., Murphy, M.B., 2011. Spatial distribution of ciguateric fish in the Republic of Kiribati. Chemosphere 84, 117-123.

Chan, W.H., Mak, Y.L., Wu, J.J., Jin, L., Sit, W.H., Lam, J.C.W., Sadovy de Mitcheson, Y., Chan, L.L., Lam, P.K.S., Murphy, M.B., 2011. Spatial distribution of ciguateric fish in the Republic of Kiribati. Chemosphere 84, 117-123.

Chanteau, S., Bagnis, R., Yasumoto, T., 1976. PURIFICATION OF CIGUATOXIN FROM ROCKING EPINEPHELUS-MICRODON (BLEECKER). Biochimie 58, 1149-1151.

Chateau-Degat, M.L., Beuter, A., Vauterin, G., Nguyen, N.L., Chinain, M., Darius, T., Legrand, A.M., Chansin, R., Dewailly, E., 2007. Neurologic signs of ciguatera disease: Evidence of their persistence. Am. J. Trop. Med. Hyg. 77, 1170-1175.

Chateau-Degat, M.L., Chinain, M., Cerf, N., Gingras, S., Hubert, B., Dewailly, E., 2005. Seawater temperature, Gambierdiscus spp. variability and incidence of ciguatera poisoning in French Polynesia. Harmful Algae 4, 1053-1062.

Chateau-Degat, M.L., Huin-Blondey, M.O., Chinain, M., Darius, T., Legrand, A.M., Nguyen, N.L., Laudon, F., Chansin, R., Dewailly, E., 2007. Prevalence of chronic symptoms of Ciguatera disease in french polynesian adults. Am. J. Trop. Med. Hyg. 77, 842-846.

Chavez, J.C., de Blas, G.A., de la Vega-Beltran, J.L., Nishigaki, T., Chirinos, M., Gonzalez-Gonzalez, M.E., Larrea, F., Solis, A., Darszon, A., Trevino, C.L., 2011. The opening of maitotoxin-sensitive calcium channels induces the acrosome reaction in human spermatozoa: differences from the zona pellucida. Asian Journal of Andrology 13, 159-165.

Chegini, S., Metcalfe, D.D., 2004. Contemporary issues in food allergy: Seafood toxin-induced disease in the differential diagnosis of allergic reactions, Eastern Allergy Conference, Key Biscayne, FL, pp. 183-190.

Chen, C.Y., Ding, X.Q., Feng, S., 2000. Studies on electronic structure and structure-activity relationship of ciguatoxin(CTX). Acta Physico-Chimica Sinica 16, 307-311.

Chen, J.L., Barritt, G.J., 2003. Evidence that TRPC1 (transient receptor potential canonical 1) forms a Ca2+-permeable channel linked to the regulation of cell volume in liver cells obtained using small interfering RNA targeted against TRPC1. Biochem. J. 373, 327-336.

Chen, L.Q., Chahine, M., Kallen, R.G., Barchi, R.L., Horn, R., 1992. CHIMERIC STUDY OF SODIUM-CHANNELS FROM RAT SKELETAL AND CARDIAC-MUSCLE. FEBS Lett. 309, 253-257.

Cheng-Hong, H., Ken-Lin, H., Ming-Ming, L.E.E., Chi-Hsun, L.A.N., Wen-Feng, L.I.N., Deng-Fwu, H., 2009. Species Identification of Ciguatoxin-Carrying Grouper Implicated in Food Poisoning. Journal of Food Protection 72, 2375-2379.

Chinain, M., Darius, H.T., Ung, A., Cruchet, P., Wang, Z., Ponton, D., Laurent, D., Pauillac, S., 2010. Growth and toxin production in the ciguatera-causing dinoflagellate Gambierdiscus polynesiensis (Dinophyceae) in culture. Toxicon 56, 739-750.

Chinain, M., Darius, H.T., Ung, A., Fouc, M.T., Revel, T., Cruchet, P., Pauillac, S., Laurent, D., 2010. Ciguatera risk management in French Polynesia: The case study of Raivavae Island (Australes Archipelago). Toxicon 56, 674-690.

Chinain, M., Faust, M.A., Pauillac, S., 1999. Morphology and molecular analyses of three toxic species of Gambierdiscus (Dinophyceae): G-pacificus, sp nov., G-australes, sp nov., and G-polynesiensis, sp nov. J. Phycol. 35, 1282-1296.

Chinain, M., Gatti, C., Roué, M., Laurent, D., Darius, H.T., 2014. The ecology, biology and toxicology of ciguatera. Revue Francophone des Laboratoires 2014, 27-39.

Chinain, M., Germain, M., Deparis, X., Pauillac, S., Legrand, A.M., 1999. Seasonal abundance and toxicity of the dinoflagellate Gambierdiscus spp (Dinophyceae), the causative agent of ciguatera in Tahiti, French Polynesia. Mar. Biol. 135, 259-267.

Choi, O.H., Padgett, W.L., Daly, J.W., 1992. EFFECTS OF THE AMPHIPHILIC PEPTIDES MELITTIN AND MASTOPARAN ON CALCIUM INFLUX, PHOSPHOINOSITIDE BREAKDOWN AND ARACHIDONIC-ACID RELEASE IN RAT PHEOCHROMOCYTOMA PC12 CELLS. J. Pharmacol. Exp. Ther. 260, 369-375.

Choi, O.H., Padgett, W.L., Nishizawa, Y., Gusovsky, F., Yasumoto, T., Daly, J.W., 1990. MAITOTOXIN - EFFECTS ON CALCIUM CHANNELS, PHOSPHOINOSITIDE BREAKDOWN, AND ARACHIDONATE RELEASE IN PHEOCHROMOCYTOMA PC12 CELLS. Mol. Pharmacol. 37, 222-230.

Choudhary, G., Aliste, M.P., Tieleman, D.P., French, R.J., Dudley, S.C., 2007. Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule. Channels 1, 344-352.

Christian, B., Luckas, B., 2008. Determination of marine biotoxins relevant for regulations: from the mouse bioassay to coupled LC-MS methods. Anal. Bioanal. Chem. 391, 117-134.

Chun Kwan, W., Hung, P., Lee, K.L.H., Kam, K.M., 2009. Solid-phase extraction clean-up of ciguatoxin-contaminated coral fish extracts for use in the mouse bioassay. Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment 26, 236-247.

Chungue, E., Bagnis, R., Parc, F., 1984. THE USE OF MOSQUITOS (AEDES-AEGYPTI) TO DETECT CIGUATOXIN IN SURGEON FISHES (CTENOCHAETUS-STRIATUS). Toxicon 22, 161-164.

Ciminiello, P., Dell' Aversano, C., Fattorusso, E., Forino, M., 2009. Chapter 1 Recent Developments in Mediterranean Harmful Algal Events, pp. 1-41.

Clark, J.S., 2006. Construction of fused polycyclic ethers by strategies involving ring-closing metathesis. Chem. Commun., 3571-3581.

Clark, J.S., Conroy, J., Blake, A.J., 2007. Rapid synthesis of the A-E fragment of ciguatoxin CTX3C. Org. Lett. 9, 2091-2094.

Clark, J.S., Hamelin, O., Hufton, R., 1998. Synthesis of medium-sized cyclic allylic ethers by ring-closing metathesis and subsequent elaboration to sub-units found in the brevetoxins and ciguatoxins. Tetrahedron Lett. 39, 8321-8324.

Clark, R.F., Williams, S.R., Nordt, S.P., Manoguerra, A.S., 1999. A review of selected seafood poisonings. Undersea & Hyperbaric Medicine 26, 175-184.

Clark, T.P., Kemppainen, R.J., 1994. GLUCOCORTICOID NEGATIVE FEEDBACK IN SHEEP CORTICOTROPHS - A COMPARISON WITH ATT-20 CORTICOTROPH TUMOR-CELLS. American Journal of Physiology 267, R463-R469.

Clark, T.P., Kemppainen, R.J., 1994. GLUCOCORTICOIDS DO NOT AFFECT INTRACELLULAR CALCIUM TRANSIENTS IN CORTICOTROPHS - EVIDENCE SUPPORTING AN EFFECT DISTAL TO CALCIUM INFLUX. Neuroendocrinology 60, 273-282.

Clement, B., Devaux, A., Perrodin, Y., Danjean, M., Ghidini-Fatus, M., 2004. Assessment of sediment ecotoxicity and genotoxicity in freshwater laboratory microcosms. Ecotoxicology 13, 323-333.

Clua, E., Brena, P.F., Lecasble, C., Ghnassia, R., Chauvet, C., 2011. Prevalence and proposal for cost-effective management of the ciguatera risk in the Noumea fish market, New Caledonia (South Pacific). Toxicon 58, 591-601.

Coleman, A.M.E., 1990. CIGUATOXIN-INDUCED FOOD POISONING IN A COMMUNITY - IMPLICATIONS FOR DISEASE SURVEILLANCE AND MEDICAL-PRACTICE IN JAMAICA. West Indian Medical Journal 39, 233-238.

Colman, J.R., Dechraoui, M.Y.B., Dickey, R.W., Ramsdell, J.S., 2004. Characterization of the developmental toxicity of Caribbean ciguatoxins in finfish embryos. Toxicon 44, 59-66.

Colman, J.R., Twiner, M.J., Hess, P., McMahon, T., Satake, M., Yasumoto, T., Doucette, G.J., Ramsdell, J.S., 2005. Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos. Toxicon 45, 881-890.

Columbo, M., Taglialatela, M., Warner, J.A., Macglashan, D.W., Yasumoto, T., Annunziato, L., Marone, G., 1992. MAITOTOXIN, A NOVEL ACTIVATOR OF MEDIATOR RELEASE FROM HUMAN BASOPHILS, INDUCES LARGE INCREASES IN CYTOSOLIC CALCIUM RESULTING IN HISTAMINE, BUT NOT LEUKOTRIENE-C(4), RELEASE. J. Pharmacol. Exp. Ther. 263, 979-986.

Columbo, M., Taglialatela, M., Warner, J.A., Macglashan, D.W., Yasumoto, T., Annunziato, L., Marone, G., 1993. ACTIVATION OF MEDIATOR RELEASE FROM HUMAN BASOPHILS BY MAITOTOXIN. Journal of Allergy and Clinical Immunology 91, 257-257.

Conn, P.M., Staley, D.D., Yasumoto, T., Huckle, W.R., Janovick, J.A., 1987. HOMOLOGOUS DESENSITIZATION WITH GONADOTROPIN-RELEASING-HORMONE (GNRH) ALSO DIMINISHES GONADOTROPE RESPONSIVENESS TO MAITOTOXIN - A ROLE FOR THE GNRH RECEPTOR-REGULATED CALCIUM-ION CHANNEL IN MEDIATION OF CELLULAR DESENSITIZATION. Mol. Endocrinol. 1, 154-159.

Connon, C., Young, R.D., Kidd, E.J., 2003. P2X(7) receptors are redistributed on human monocytes after pore formation in response to prolonged agonist exposure. Pharmacology 67, 163-168.

Connor, M., Henderson, G., 1996. delta- and mu-Opioid receptor mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells. Br. J. Pharmacol. 117, 333-340.

Connor, M., Yeo, A., Henderson, G., 1997. Neuropeptide Y Y-2 receptor and somatostatin sst(2) receptor coupling to mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells. Br. J. Pharmacol. 120, 455-463.

Cook, L.R., Oinuma, H., Semones, M.A., Kishi, Y., 1997. The stereochemical assignment and conformational analysis of the V/W-ring juncture of maitotoxin. J. Am. Chem. Soc. 119, 7928-7937.

Coombe, I.F., Capra, M.F., Flowers, A.E., Cameron, J., 1988. PATHOLOGICAL-CHANGES IN THE MAMMALIAN GUT FOLLOWING ADMINISTRATION OF CIGUATOXIN. Toxicon 26, 19-19.

Copeland, N.K., Palmer, W.R., Bienfang, P.K., 2014. Ciguatera fish poisoning in Hawai'i and the Pacific. Hawaii J Med Public Health 73, 24-27.

Coraboeuf, E., Coulombe, A., Deroubaix, E., Faivre, J.F., Legrand, A.M., 1988. EFFECTS OF MAITOTOXIN ON CALCIUM AND BACKGROUND CURRENTS IN ISOLATED RAT CARDIAC VENTRICULAR CELLS. J. Physiol.-London 406, P81-P81.

Corpuz, G.P., Grothaus, P.G., Waller, D.F., Bignami, G.S., 1994

1995. An HPLC method for rapid analysis of palytoxin congeners and prodrugs, in: Hokama, Y., Scheuer, P.J., Yasumoto, T. (Eds.), Proceedings of the International Symposium on Ciguatera and Marine Natural Products. Asian-Pacific Research Foundation, Honolulu, Hawaii, pp. 145-153.

Corrales, R.A., Maclean, J.L., 1995. IMPACTS OF HARMFUL ALGAE ON SEAFARMING IN THE ASIA-PACIFIC AREAS. J. Appl. Phycol. 7, 151-162.

Crouch, R.C., Martin, G.E., Musser, S.M., Grenade, H.R., Dickey, R.W., 1995. IMPROVEMENTS IN THE SENSITIVITY OF INVERSE-DETECTED HETERONUCLEAR CORRELATION SPECTRA USING MICRO INVERSE PROBES AND MICRO CELLS - HMQC AND HMBC SPECTRA OF CARIBBEAN CIGUATOXIN - PRELIMINARY STRUCTURAL INFERENCES. Tetrahedron Lett. 36, 6827-6830.

Crump, J.A., McLay, C.L., Chambers, S.T., 1999. : Ciguatera fish poisoning. : New Zealand Medical Journal. Jul 112, 282-283.

Cruz-Cruz, R., Salgado, A., Sanchez-Soto, C., Vaca, L., Hiriart, M., 2005. Thapsigargin-sensitive cationic current leads to membrane depolarization, calcium entry, and insulin secretion in rat pancreatic beta-cells. Am. J. Physiol.-Endocrinol. Metab. 289, E439-E445.

Cruz-Rivera, E., Villareal, T.A., 2006. Macroalgal palatability and the flux of ciguatera toxins through marine food webs. Harmful Algae 5, 497-525.

Currie, B.J., 2003. Marine antivenoms. Journal of Toxicology-Clinical Toxicology 41, 301-308.

Cuypers, E., Abdel-Mottaleb, Y., Kopljar, I., Rainier, J.D., Raes, A.L., Snyders, D.J., Tytgat, J., 2008. Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels. Toxicon 51, 974-983.

D., D., Fujiwara K., A., M., H., K., T., S., 2005. Convergent synthesis of the IJKLM-ring of ciguatoxin CTX3C. Tetrahedton Letters 46, 8285-8288.

D., D., K., F., T., O., A., T., S., T., H.., K., A., M., H.., K., T., S., 2005. Synthesis of the C42-C52 part of ciguatoxin CTX3C. Tetrahedron Lett. 46, 8279-8283.

D.L., P., 1994. Evolution of methods for assessing ciguatera toxins in fish. Rev. Environ. Contam. Toxicol. 136, 1-20.

Dalsgaard, A., Mazur, J., Dalsgaard, I., 2002. Misidentification of Vibrio cholerae O155 isolated from imported shrimp as O serogroup O139 due to cross-agglutination with commercial O139 antisera. Journal of Food Protection 65, 670-672.

Daly, J.W., Harper, J., 2000. Loperamide: novel effects on capacitative calcium influx. Cell. Mol. Life Sci. 57, 149-157.

Daly, J.W., Lueders, J., Padgett, W.L., Shin, Y., Gusovsky, F., 1995. MAITOTOXIN-ELICITED CALCIUM INFLUX IN CULTURED-CELLS EFFECT OF CALCIUM-CHANNEL - EFFECT OF CALCIUM-CHANNEL BLOCKERS. Biochem. Pharmacol. 50, 1187-1197.

Darius, H.T., Drescher, O., Ponton, D., Pawlowiez, R., Laurent, D., Dewailly, E., Chinain, M., 2013. Use of folk tests to detect ciguateric fish: a scientific evaluation of their effectiveness in Raivavae Island (Australes, French Polynesia). Food Addit Contam Part A Chem Anal Control Expo Risk Assess 30, 550-566.

Darius, H.T., Ponton, D., Revel, T., Cruchet, P., Ung, A., Fouc, M.T., Chinain, M., 2007. Ciguatera risk assessment in two toxic sites of French Polynesia using the receptor-binding assay. Toxicon 50, 612-626.

Davin, W.T., Kohler, C.C., Tindall, D.R., 1988. Ciguatera Toxins Adversely Affect Piscivorous Fishes. Trans. Am. Fish. Soc. 117, 374-384.

de Haro, L., Pommier, P., Valli, M., 2003. Emergence of imported ciguatera in Europe: Report of 18 cases at the Poison Control Centre of Marseille. Journal of Toxicology-Clinical Toxicology 41, 927-930.

de la Rosa, L.A., Alfonso, A., Vilarino, N., Vieytes, M.R., Botana, L.M., 2000. Modulation of cytosolic calcium levels of human lymphocytes by yessotoxin, a novel marine phycotoxin, 9th International Conference on Harmful Algal Blooms, Hobart, Australia, pp. 827-833.

de la Rosa, L.A., Alfonso, A., Vilarino, N., Vieytes, M.R., Botana, L.M., 2001. Modulation of cytosolic calcium levels of human lymphocytes by yessotoxin, a novel marine phycotoxin. Biochem. Pharmacol. 61, 827-833.

de la Rosa, L.A., Alfonso, A., Vilarino, N., Vieytes, M.R., Yasumoto, T., Botana, L.M., 2001. Maitotoxin-induced calcium entry in human lymphocytes - Modulation by yessotoxin, Ca2+ channel blockers and kinases. Cell. Signal. 13, 711-716.

De Ribes, G.C., Rasolofonirina, R.N., Ranaivoson, G., Razafimahefa, N., Rakotoson, J.D., Rabeson, D., 1997. Seafood poisonings in Madagascar - Ichthyosarcotoxicity and chelonitoxicity: Ichthyoscarotoxicity and chelonitoxicity: Recent epidemiological data. Bulletin De La Societe De Pathologie Exotique 90, 286-290.

de Schroeder, T.F., de D'Angelo, A.M.P., 2000. The turnover of phospholipid fatty acyl chains is activated by the insecticide Dieldrin in Bufo arenarum oocytes. J. Biochem. Mol. Toxicol. 14, 82-87.

Dechraoui Bottein, M.-Y., Wang, Z., Ramsdell, J.S., 2011. Toxicokinetics of the ciguatoxin P-CTX-1 in rats after intraperitoneal or oral administration. Toxicology 284, 1-6.

Dechraoui, M.Y., Naar, J., Pauillac, S., Legrand, A.M., 1999. Ciguatoxins and brevetoxins, neurotoxic polyether compounds active on sodium channels. Toxicon 37, 125-143.

Dechraoui, M.-Y., Naar, J., Pauillac, S., Legrand, A.-M., 1999. Ciguatoxins and brevetoxins, neurotoxic polyether compounds active on sodium channels. Toxicon 37, 125-143.

Dechraoui, M.Y.B., Ramsdell, J.S., 2003. Type B brevetoxins show tissue selectivity for voltage-gated sodium channels: comparison of brain, skeletal muscle and cardiac sodium channels. Toxicon 41, 919-927.

Dechraoui, M.Y.B., Rezvani, A.H., Gordon, C.J., Levin, E.D., Ramsdell, J.S., 2008. Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: Relationship to blood ciguatoxin concentrations. Toxicology 246, 55-62.

Dechraoui, M.Y.B., Tiedeken, J.A., Persad, R., Wang, Z.H., Granade, H.R., Dickey, R.W., Ramsdell, J.S., 2005. Use of two detection methods to discriminate ciguatoxins from brevetoxins: Application to great barracuda from Florida Keys. Toxicon 46, 261-270.

Dechraoui, M.Y.B., Wacksman, J.J., Ramsdell, J.S., 2006. Species selective resistance of cardiac muscle voltage gated sodium channels: Characterization of brevetoxin and ciguatoxin binding sites in rats and fish. Toxicon 48, 702-712.

Dechraoui, M.Y.B., Wang, Z.H., Ramsdell, J.S., 2007. Optimization of ciguatoxin extraction method from blood for Pacific ciguatoxin (P-CTX-1). Toxicon 49, 100-105.

Dechraoui, M.Y.B., Wang, Z.H., Turquet, J., Chinain, M., Darius, T., Cruchet, P., Radwan, F.F.Y., Dickey, R.W., Ramsdell, J.S., 2005. Biomonitoring of ciguatoxin exposure in mice using blood collection cards. Toxicon 46, 243-251.

Deeds, J.R., Place, A.R., 2006. Sterol-specific membrane interactions with the toxins from Karlodinium micrum (Dinophyceae) - a strategy for self-protection? Afr. J. Mar. Sci. 28, 421-425.

Deeds, J.R., Reimschuessel, R., Place, A.R., 2006. Histopathological effects in fish exposed to the toxins from Karlodinium micrum. Journal of Aquatic Animal Health 18, 136-148.

Deeds, J.R., Schwartz, M.D., 2010. Human risk associated with palytoxin exposure. Toxicon 56, 150-162.

Delgado, G., Lechuga-Deveze, C.H., Popowski, G., Troccoli, L., Salinas, C.A., 2006. Epiphytic dinoflagellates associated with ciguatera in the northwestern coast of Cuba. Revista De Biologia Tropical 54, 299-310.

Derouiche, F., Cohen, E., Rodier, G., Boulay, C., Courtois, S., 2000. Ciguatera and peripheral neuropathy: a case report. Revue Neurologique 156, 514-516.

Desylva, D.P., 1994. DISTRIBUTION AND ECOLOGY OF CIGUATERA FISH POISONING IN FLORIDA, WITH EMPHASIS ON THE FLORIDA-KEYS. Bulletin of Marine Science 54, 944-954.

Diakov, A., Koch, J.P., Ducoudret, O., Muller-Berger, S., Fromter, E., 2001. The disulfonic stilbene DIDS and the marine poison maitotoxin activate the same two types of endogenous cation conductance in the cell membrane of Xenopus laevis oocytes. Pflugers Arch. 442, 700-708.

Diaz, M.T., Perez, R.L., Rodriguez, E., Ravelo, J.L., Martin, J.D., 2001. Convergent synthesis of trans-fused oxane ring systems based on Ni-II/Cr-II-mediated cross-coupling reactions. Synlett, 345-348.

Dickey, R.W., 2008. Ciguatera toxins: chemistry, toxicology and detection. Chapter 22 in. Seafood and freshwater toxins - Pharmacology, Physiology and Detection; ed. L. Botana. CRC Press, Taylor & Francis Group, ISBN: 0-8493-7437-5.

Dickey, R.W., Bencsath, F.A., Granade, H.R., Lewis, R.J., 1992. Liquid chromatographic mass spectrometric methods for the determination of amrine polyether toxins. Bulletin de la Societe de Pathologie Exotique [Bull. Soc. Path. Ex.] 85, 514-515.

Dickey, R.W., Miller, D.M., Tindall, D.R., 1982. THE EXTRACTION AND EFFECTS OF CRUDE CIGUATOXIN FROM SCOMBEROMORUS-CAVALLA UPON ACETYLCHOLINE AND HISTAMINE-RECEPTOR SITES OF THE GUINEA-PIG ILEUM. Federation Proceedings 41, 1562-1562.

Dickey, R.W., Plakas, S.M., 2010. Ciguatera: A public health perspective. Toxicon 56, 123-136.

Dierking, F., Cawpora, C.E., 2009. Ciguatera in the Introduced Fish Cephalopholis argus (Serranidae) in Hawai'i and Implications for Fishery Management. Pacific Science 63, 193-204.

Dietl, P., Haller, T., Wirleitner, B., Volkl, H., Friedrich, F., Striessnig, J., 1995. Activation of L-type Ca2+ channels after purinoceptor stimulation by ATP in an alveolar epithelial cell (L2). Am. J. Physiol.-Lung Cell. Mol. Physiol. 269, L873-L883.

Dietl, P., Volkl, H., 1994. MAITOTOXIN (MTX) ACTIVATES A NONSELECTIVE CATION CHANNEL (NSCC) PRIOR TO CALCIUM-ENTRY. Biophys. J. 66, A429-A429.

Dietl, P., Volkl, H., 1994. MAITOTOXIN ACTIVATES A NONSELECTIVE CATION CHANNEL AND STIMULATES CA2+ ENTRY IN MDCK RENAL EPITHELIAL-CELLS. Mol. Pharmacol. 45, 300-305.

Dinubile, M.J., Hokama, Y., 1995. THE CIGUATERA POISONING SYNDROME FROM FARM-RAISED SALMON. Ann. Intern. Med. 122, 113-114.

Diogene, G., Dubreuil, A., Breittmayer, J.P., Puiseuxdao, S., 1994. CYTOTOXIC QUANTIFICATION OF MAITOTOXIN-LIKE ACTIVITY FROM THE DINOFLAGELLATE GAMBIERDISCUS-TOXICUS. Toxicol. Vitro 8, 37-&.

Diogene, G., Fessard, V., Dubreul, A., Puiseux-Dao, S., 1995. Comparative studies of the actin cytoskeleton response to maitotoxin and okadaic acid. Toxicology In Vitro [Toxicol. in Vitro] 9, 1-10.

Domon, D., Fujiwara, K., Murai, A., Kawai, H., Suzuki, T., 2005. Convergent synthesis of the IJKLM-ring part of ciguatoxin CTX3C. Tetrahedron Lett. 46, 8285-8288.

Domon, D., Fujiwara, K., Ohtaniuchi, Y., Takezawa, A., Takeda, S., Kawasaki, H., Murai, A., Kawai, H., Suzuki, T., 2005. Synthesis of the C42-C52 part of ciguatoxin CTX3C. Tetrahedron Lett. 46, 8279-8283.

Donnelly-Roberts, D.L., Namovic, M.T., Faltynek, C.R., Jarvis, M.F., 2004. Mitogen-activated protein kinase and caspase signaling pathways are required for P2X(7) receptor (P2X(7)R)-induced pore formation in human THP-1 cells. J. Pharmacol. Exp. Ther. 308, 1053-1061.

Dorta, R.L., Freire, R., Martin, A., Suarez, E., Prange, T., 1995. CIS-FUSED AND TRANS-FUSED DI-TETRAHYDROPYRANS BY REARRANGEMENT STEROIDAL SPIROACETALS. Tetrahedron Lett. 36, 7309-7312.

Du, Y.G., Chen, Q., Linhardt, R.J., 2006. The first total synthesis of sporiolide A. J. Org. Chem. 71, 8446-8451.

Dudley, S.C., Todt, H., Lipkind, G., Fozzard, H.A., 1995. A mu-conotoxin-insensitive Na+ channel mutant: Possible localization of a binding site at the outer vestibule. Biophys. J. 69, 1657-1665.

Dutta, S., Chiu, Y.C., Probert, A.W., Wang, K.K.W., 2002. Selective release of calpain produced alpha II-spectrin (alpha-fodrin) breakdown products by acute neuronal cell death. Biol. Chem. 383, 785-791.

E.F, R., 1987. Seafood toxins. JAOAC International 70, 285-287.

Ebesu, J., 1999. Ciguatera fish poisoning. Canadian Medical Association Journal 160, 1127-1128.

Ebesu, J.S.M., 1998. Isolation and characterization of novel ciguateric compounds from Acanthurus triostegus (Manini). Univ. of Hawaii, Honolulu, HI, USA, p. 143 pp.

Ebesu, J.S.M., Nagai, H., Hokama, Y., 1994. The first reported case of human ciguatera possibly due to a farm-cultured salmon. Toxicon 32, 1282-1286.

Edebo, 1988. : Toxic mussels and okadaic acid induce rapid hypersecretion in the rat small intestine. Apmis 96, 1029-1035.

Edmunds, J.S.G., McCarthy, R.A., Ramsdell, J.S., 1999. Ciguatoxin reduces larval survivability in finfish. Toxicon 37, 1827-1832.

EFSA, 2010. Marine biotoxins in shellfish - Emerging Toxins: Ciguatoxin-group, Scientific Opinion of the Panel on Contaminants in the Food chain; adopted on 18 May 2010. EFSA Journal 8, 1-38.

Egido, W., Castrejon, V., Anton, B., Martinez, M., 2008. Maitotoxin induces two dose-dependent conductances in Xenopus oocytes. Comparison with nystatin effects as a pore inductor. Toxicon 51, 797-812.

Egido, W., Martinez, M., 2007. Maitotoxin and nystatin currents in Xenopus oocytes. Biophys. J., 613A-613A.

Empey Campora, C., 2008. Detection of ciguatoxin in fish tissue using sandwich ELISA and. J Clin Lab Anal 22, 246-253.

Empey-Campora, C., Hokama, Y., Yabusaki, K., Isobe, M., 2007. Development and validation of an enzyme-linked immunosorbent assay (ELISA) for the detection of ciguatoxin using chicken immunoglobulin Y as an analytic tool, Experimental Biology 2007 Annual Meeting. Federation Amer Soc Exp Biol, Washington, DC, pp. A1140-A1140.

Endean, R., Griffith, J.K., Robins, J.J., Llewellyn, L.E., Monks, S.A., 1993. VARIATION IN THE TOXINS PRESENT IN CIGUATERIC NARROW-BARRED SPANISH MACKEREL, SCOMBEROMORUS-COMMERSONI. Toxicon 31, 723-732.

Endean, R., Griffith, J.K., Robins, J.J., Monks, S.A., 1993. MULTIPLE TOXINS IN A SPECIMEN OF THE NARROW-BARRED SPANISH MACKEREL, SCOMBEROMORUS-COMMERSONI. Toxicon 31, 195-204.

Endean, R., Monks, S.A., Griffith, J.K., Llewellyn, L.E., 1993. APPARENT RELATIONSHIPS BETWEEN TOXINS ELABORATED BY THE CYANOBACTERIUM TRICHODESMIUM-ERYTHRAEUM AND THOSE PRESENT IN THE FLESH OF THE NARROW-BARRED SPANISH MACKEREL SCOMBEROMORUS-COMMERSONI. Toxicon 31, 1155-1165.

Engelbrecht, A.M., Engelbrecht, P., Genade, S., Niesler, C., Page, C., Smuts, M., Lochner, A., 2005. Effect of double bonds on the conducting properties of ciguatoxin 3C and tetrahydropyrane-based polymers: A theoretical study.

Epelboin, L., Perignon, A., Hossen, V., Vincent, R., Krys, S., Caumes, E., 2014. Two Clusters of Ciguatera Fish Poisoning in Paris, France, Related to Tropical Fish Imported From the French Caribbean by Travelers. Journal of Travel Medicine 21, 397-402.

Eriksson, L., Guy, S., Perlmutter, P., Lewis, R., 1999. A short synthesis of the A/B ring systems of the Pacific ciguatoxins P-CTX-3C and dihydroxy-P-CTX-3C. J. Org. Chem. 64, 8396-8398.

Espinna, B., Cagide, E., Louzao, M.C., Fernandez, M.M., Vieytes, M.R., Katikou, P., Villar, A., Jaen, D., Maman, L., Botana, L.M., 2009. Specific and dynamic detection of palytoxins by in vitro microplate assay with human neuroblastoma cells. Biosci. Rep. 29, 13-23.

Estacion, M., Nguyen, H.B., Gargus, J.J., 1996. Calcium is permeable through a maitotoxin-activated nonselective cation channel in mouse L cells. Am. J. Physiol.-Cell Physiol. 270, C1145-C1152.

Estacion, M., Schilling, W.P., 2001. Blockade of maitotoxin-induced Ca2+ influx, vital dye uptake, and oncotic cell death by U73122 and U73343. Faseb J. 15, A940-A940.

Estacion, M., Schilling, W.P., 2001. Maitotoxin induces pores that correlate with dye uptake in bovine aortic endothelial cells. Biophys. J. 80, 244A-244A.

Estacion, M., Schilling, W.P., 2001. Maitotoxin-induced membrane blebbing and cell death in aortic endothelial cells. Faseb J. 15, A940-A940.

Estacion, M., Sinkins, W.G., Schilling, W.P., 1999. Maitotoxin induces vital dye permeant pores subsequent to channel activation. Biophys. J. 76, A208-A208.

Estacion, M., Weinberg, J.S., Sinkins, W.G., Schilling, W.P., 2003. Blockade of maitotoxin-induced endothelial cell lysis by glycine and L-alanine. Am. J. Physiol.-Cell Physiol. 284, C1006-C1020.

Estevez, M.D., Vieytes, M.R., Botana, L.M., 1996. Mitoxantrone induces nonimmunological histamine release from rat mast cells. Inflamm. Res. 45, 113-117.

Evans, P.A., Delouvrie, B., 2002. Recent developments in the construction of trans-fused polycyclic ethers. Curr. Opin. Drug Discov. Dev. 5, 986-999.

F.P., R., 1985. Report on seafood toxins. JAOAC International 68, 252-254.

Faden, A.I., Knoblach, S.M., Cernak, I., Fan, L., Vink, R., Araldi, G.L., Fricke, S.T., Roth, B.L., Kozikowski, A.P., 2003. Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo. Journal of Cerebral Blood Flow and Metabolism 23, 342-354.

Fairey, E.R., Edmunds, J.S.G., Ramsdell, J.S., 1997. A cell-based assay for brevetoxins, saxitoxins, and ciguatoxins using a stably expressed c-fos-luciferase reporter gene. Anal. Biochem. 251, 129-132.

Fairey, E.R., Ramsdell, J.S., 1999. Reporter gene assays for algal-derived toxins. Natural Toxins 7, 415-421.

Faivre, J.F., Deroubaix, E., Coulombe, A., Legrand, A.M., Coraboeuf, E., 1990. EFFECT OF MAITOTOXIN ON CALCIUM CURRENT AND BACKGROUND INWARD CURRENT IN ISOLATED VENTRICULAR RAT MYOCYTES. Toxicon 28, 925-937.

Farstad, D.J., Chow, T., 2001. A brief case report and review of ciguatera poisoning. Wildern. Environ. Med. 12, 263-269.

Faruque, S.M., Albert, M.J., Mekalanos, J.J., 1998. Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae. Microbiology and Molecular Biology Reviews 62, 1301-+.

Fasano, A., Hokama, Y., Russell, R., Morris, J.G., 1991. DIARRHEA IN CIGUATERA FISH POISONING - PRELIMINARY EVALUATION OF PATHOPHYSIOLOGICAL MECHANISMS. Gastroenterology 100, 471-476.

Fatatis, A., Bassi, A., Iannotti, E., Caso, N., Mita, G.D., Direnzo, G., Annunziato, L., 1994. APPEARANCE OF DEPOLARIZATION-INDUCED AND MAITOTOXIN-INDUCED CA2+ (I) ELEVATION IN SINGLE LAN-1 HUMAN NEUROBLASTOMA-CELLS ON EXPOSURE TO RETINOIC ACID. J. Neurochem. 63, 1900-1907.

Faust, M.A., 1991. Morphology of ciguatera-causing Prorocentrum lima (pyrrophyta) from widely differing sites. Journal of Phycology [J. Phycol.], 642-648.

Faust, M.A., 1991. MORPHOLOGY OF CIGUATERA-CAUSING PROROCENTRUM-LIMA (PYRROPHYTA) FROM WIDELY DIFFERING SITES. J. Phycol. 27, 642-648.

Faust, M.A., Vandersea, M.W., Kibler, S.R., Tester, P.A., Litaker, R.W., 2008. Prorocentrum levis, a new benthic species (dinophyceae) from a mangrove island, twin cays, belize. J. Phycol. 44, 232-240.

Fenner, P.J., Lewis, R.J., Williamson, J.A., Williams, M.L., 1997. A Queensland family with ciguatera after eating coral trout. Medical J. Australia 166, 473-475.

Fessard, V., Diogene, G., Dubreuil, A., Quod, J.P., Durand, C.M., Legay, C., Puiseux, D.S., 1994. : Selection of cytotoxic responses to maitotoxin and okadaic acid and evaluation of toxicity of dinoflagellate extracts. : Nat. Toxins 2, 322-328.

Fessard, V., Diogene, G., Dubreuil, A., Quod, J.P., Durand-Clement, M., Legay, C., Puiseux-Dao, S., 1994. Selection of cytotoxic responses to maitotoxin and okadaic acid and evaluation of toxicity of dinoflagellate extracts. Nat. Toxins 2, 322-328.

Fitzpatrick, L.A., Yasumoto, T., Aurbach, G.D., 1989. INHIBITION OF PARATHYROID-HORMONE RELEASE BY MAITOTOXIN, A CALCIUM-CHANNEL ACTIVATOR. Endocrinology 124, 97-103.

Flaherty, J., 1987. A possible case of ciguatera poisoning. Ont. Dis. Surv. Rep. 8, 24.

Fleming, L.E., Jerez, E., Stephan, W.B., Cassedy, A., Bean, J.A., Reich, A., Kirkpatrick, B., Backer, L., Nierenberg, K., Watkins, S., Hollenbeck, J., Weisman, R., 2007. Evaluation of Harmful algal bloom outreach activities. Mar. Drugs 5, 208-219.

Flowers, A.E., Capra, M.F., Cameron, J., 1988. THE EFFECTS OF CIGUATOXIN ON NERVE-CONDUCTION PARAMETERS IN TELEOST FISH. Toxicon 26, 20-20.

Fraga, S., Rodriguez, F., Caillaud, A., Diogene, J., Raho, N., Zapata, M., 2011. Gambierdiscus excentricus sp nov (Dinophyceae), a benthic toxic dinoflagellate from the Canary Islands (NE Atlantic Ocean). Harmful Algae 11, 10-22.

Freedman, S.B., Miller, R.J., Miller, D.M., Tindall, D.R., 1984. INTERACTIONS OF MAITOTOXIN WITH VOLTAGE-SENSITIVE CALCIUM CHANNELS IN CULTURED NEURONAL CELLS. Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 81, 4582-4585.

Frelin, C., Durandclement, M., Bidard, J.N., Lazdunski, M., 1990. THE MOLECULAR-BASIS OF CIGUATOXIN ACTION. Acs Symposium Series 418, 192-199.

Frenette, C., MacLean, J.D., Gyorkos, T.W., 1988. A large common source outbreak of ciguatera fish poisoning. Journal of Infectious Diseases [J. Infect. Dis.] 158, 1128-1131.

Friedman, M., Fleming, L., Fernandez, M., Bienfang, P., Schrank, K., Dickey, R., Bottein, M.-Y., Backer, L., Ayyar, R., Weisman, R., Watkins, S., Granade, R., Reich, A., 2008. Ciguatera Fish Poisoning: Treatment, Prevention and Management. Mar. Drugs 6, 456-479.

Friedman, M.A., Arena, P., Levin, B., Fleming, L., Fernandez, M., Weisman, R., Bernstein, J., Schrank, K., Blythe, D., Backer, L., Reich, A., 2007. Neuropsychological study of ciguatera fish poisoning: A longitudinal case-control study. Arch. Clin. Neuropsychol. 22, 545-553.

Friedman, M.A., Fleming, L.E., Fernandez, M., Bienfang, P., Schrank, K., Dickey, R., Bottein, M.Y., Backer, L., Ayyar, R., Weisman, R., Watkins, S., Granade, R., Reich, A., 2008. Ciguatera fish poisoning: Treatment, prevention and management. Mar. Drugs 6, 456-479.

Friedman, M.A., Levin, B.E., 2005. Neurobehavioral effects of harmful algal bloom (HAB) toxins: A critical review. Journal of the International Neuropsychological Society 11, 331-338.

Fu, F., Place, A.R., Garcia, N.S., Hutchins, D.A., 2010. CO2 and phosphate availability control the toxicity of the harmful bloom dinoflagellate Karlodinium veneficum. Aquat. Microb. Ecol. 59, 55-65.

Fujiwara, K., 2007. Synthesis of prelaureatin, laurencin, and the medium-ring ether parts of ciguatoxins. J. Synth. Org. Chem. Jpn. 65, 502-510.

Fujiwara, K., Goto, A., Sato, D., Ohtaniuchi, Y., Tanaka, H., Murai, A., Kawai, H., Suzuki, T., 2004. Convergent synthesis of the ABCDE-ring part of ciguatoxin CTX3C. Tetrahedron Lett. 45, 7011-7014.

Fujiwara, K., Kawamura, N., Kawai, H., Suzuki, T., 2009. Stereoselective construction of an anti-beta-alkoxy ether by Ireland-Claisen rearrangement for medium-ring ether synthesis. Tetrahedron Lett. 50, 1236-1239.

Fujiwara, K., Koyama, Y., Doi, E., Shimawaki, K., Ohtaniuchi, Y., Takemura, A., Souma, S.I., Murai, A., 2002. Syntheses of the D-, E-, F-, and I-Ring parts of ciguatoxin by a common strategy starting from tri-O-acetyl-D-glucal. Synlett, 1496-1499.

Fujiwara, K., Koyama, Y., Kawai, K., Tanaka, H., Murai, A., 2002. Convergent synthesis of the BCDE-ring part of ciguatoxin. Synlett, 1835-1838.

Fujiwara, K., Takaoka, D., Kusumi, K., Kawai, K., Murai, A., 2001. Convergent syntheses of the enantiomeric CD- and JK-ring parts of ciguatoxin. Synlett, 691-693.

Fujiwara, K., Tanaka, H., Murai, A., 2000. Asymmetric synthesis of the A-ring part of ciguatoxin by the strategy based on diastereoselective hydroboration and ring closing metathesis. Chem. Lett., 610-611.

Fujiwara, K., Tanaka, K., Katagiri, Y., Kawai, H., Suzuki, T., 2010. Model studies for the stereoselective construction of the BC-ring of armatol F based on Ireland-Claisen rearrangement and relay ring-closing olefin metathesis. Tetrahedron Lett. 51, 4543-4546.

Fukuyo, Y., 2008. Toxic benthic microalgae in the western Pacific region. Nippon Suisan Gakkaishi 74, 909-910.

Furihata, K., Seto, H., 1999. J-resolved HMBC, a new NMR technique for measuring heteronuclear long-range coupling constants. Tetrahedron Lett. 40, 6271-6275.

Furukawa, H., Kiyota, H., Yamada, T., Yaosaka, M., Takeuchi, R., Watanabe, T., Kuwahara, S., 2007. Stereochemistry of enacyloxins - Part 4 - Complete structural and configurational assignment of the enacyloxin family, a series of antibiotics from Frateuria sp W-315. Chemistry & Biodiversity 4, 1601-1604.

Furuta, H., Hasegawa, Y., Hase, M., Mori, Y., 2010. Total Synthesis of Gambierol by Using Oxiranyl Anions. Chem.-Eur. J. 16, 7586-7595.

Fuwa, H., 2014. Gambierol, Seafood and Freshwater Toxins. CRC Press, pp. 895-924.

Fuwa, H., Fujikawa, S., Tachibana, K., Takakura, H., Sasaki, M., 2004. Convergent synthesis of the ABCDE ring fragment of ciguatoxins. Tetrahedron Lett. 45, 4795-4799.

Fuwa, H., Sasaki, M., 2007. Recent advances in the synthesis of marine polycyclic ether natural products. Curr. Opin. Drug Discov. Dev. 10, 784-806.

Gaboriau, M., Ponton, D., Darius, H.T., Chinain, M., 2014. Ciguatera fish toxicity in French Polynesia: Size does not always matter. Toxicon 84, 41-50.

Gallimore, A.R., Spencer, J.B., 2006. Stereochemical uniformity in marine polyether ladders-implications for the biosynthesis and structure of maitotoxin. Angew. Chem.-Int. Edit. 45, 4406-4413.

Ganal, C.A., Asahina, A.Y., Hokama, Y., Miyahara, J.T., 1993. CHARACTERIZATION OF MARINE TOXIN(S) IN MYRIPRISTIS SP BY IMMUNOLOGICAL, MOUSE TOXICITY, AND GUINEA-PIG ASSAYS. J. Clin. Lab. Anal. 7, 41-45.

Gartland, A., Buckley, K.A., Hipskind, R.A., Perry, M.J., Tobias, J.H., Buell, G., Chessell, I., Bowler, W.B., Gallagher, J.A., 2003. Multinucleated osteoclast formation in vivo and in vitro by P2X(7) receptor-deficient mice. Critical Reviews in Eukaryotic Gene Expression 13, 243-253.

Gascon, J., Macia, M., Oliveira, L., Corachan, M., 2003. Ciguatera poisoning in Spanish travellers. Medicina Clinica 120, 777-779.

Gatti, C., 2014. Etat de la ciguatéra en Polynésie Française, Réseau de Surveillance de la Ciguatéra, Tahiti.

Gatti, C., Oelher, E., Legrand, A.M., 2008. Severe seafood poisoning in French Polynesia: A retrospective analysis of 129 medical files. Toxicon 51, 746-753.

GaudryTalarmain, Y.M., Molgo, J., Meunier, F.A., Moulian, N., Legrand, A.M., 1995. Reversed mode Na+-Ca2+ exchange activated by ciguatoxin (CTX-1b) enhances acetylcholine release from Torpedo cholinergic synaptosomes, in: Hilgemann, D.W., Philipson, K.D., Vassort, G. (Eds.), 3rd International Conference on Sodium-Calcium Exchange, Woods Hole, Ma, pp. 404-406.

Gawley, R.E., Rein, K.S., Kinoshita, M., Baden, D.G., 1992. Binding of brevetoxins and ciguatoxin to the voltage-sensitive sodium channel and conformational analysis of brevetoxin B. Toxicon 30, 780-785.

Geller, R.J., Olson, K.R., Senecal, P.E., 1991. CIGUATERA FISH POISONING IN SAN-FRANCISCO, CALIFORNIA, CAUSED BY IMPORTED BARRACUDA. Western Journal of Medicine 155, 639-642.

Ghiaroni, V., Fuwa, H., Inoue, M., Sasaki, M., Miyazaki, K., Hirama, M., Yasumoto, T., Rossini, G.P., Scalera, G., Bigiani, A., 2006. Effect of ciguatoxin 3C on voltage-gated Na+ and K+ currents in mouse taste cells. Chem. Senses 31, 673-680.

Ghiaroni, V., Sasaki, M., Fuwa, H., Rossini, G.P., Scalera, G., Yasumoto, T., Pietra, P., Bigiani, A., 2005. Inhibition of voltage-gated potassium currents by gambierol in mouse taste cells. Toxicol. Sci. 85, 657-665.

Gillespie, N.C., Lewis, R.J., Pearn, J.H., Bourke, A.T.C., Holmes, M.J., Bourke, J.B., Shields, W.J., 1986. Ciguatera in Australia: Occurrence, clinical features, pathophysiology and management. Medical Journal of Australia [Med. J. Australia] 145, 584-590.

Girard, J.P., Graillet, C., Pesando, D., Payan, P., 1996. Calcium homeostasis and early embryotoxicity in marine invertebrates. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology 113, 169-175.

Glantz, S.B., Cianci, C.D., Iyer, R., Pradhan, D., Wang, K.K.W., Morrow, J.S., 2007. Sequential degradation of alpha II and beta II spectrin by calpain in glutamate or maitotoxin-stimulated cells. Biochemistry 46, 502-513.

Glaziou, P., Legrand, A.-M., 1994. The epidemiology of ciguatera fish poisoning. Toxicon 32, 863-873.

Glaziou, P., Legrand, A.M., 1994. THE EPIDEMIOLOGY OF CIGUATERA FISH POISONING. Toxicon 32, 863-873.

Goater, S., Derne, B., Weinstein, P., 2011. Critical Issues in the Development of Health Information Systems in Supporting Environmental Health: A Case Study of Ciguatera. Environ. Health Perspect. 119, 585-590.

Golovko, V.B., Mays, M.J., Solan, G.A., 2008. Self-cyclisation versus diynediol-promoted ring closure during the construction of coordinated crown-type macrocycles. Polyhedron 27, 167-174.

Golubic, S., Abed, R.M.M., Palińska, K., Pauillac, S., Chinain, M., Laurent, D., 2010. Marine toxic cyanobacteria: Diversity, environmental responses and hazards. Toxicon 56, 836-841.

Gomi, S., Chaen, S., Sugi, H., 1984. THE MODE OF ACTION OF MAITOTOXIN ON THE MEMBRANE SYSTEMS OF FROG SKELETAL-MUSCLE FIBERS. Proc. Jpn. Acad. Ser. B-Phys. Biol. Sci. 60, 28-31.

Goodman, A., Williams, T.N., Maitland, K., 2003. Ciguatera poisoning in Vanuatu. Am. J. Trop. Med. Hyg. 68, 263-266.

Gopal, S., Otta, S.K., Kumar, S., Karunasagar, I., Nishibuchi, M., 2005. The occurrence of Vibrio species in tropical shrimp culture environments; implications for food safety. Int. J. Food Microbiol. 102, 151-159.

Gordon, C.J., Ramsdell, J.S., 2003. Effects of marine algal toxins on thermoregulation in mice, Symposium on Marine Toxin Impacts on Neurobehavioral Function, Philadelphia, PA, pp. 727-731.

Gordon, C.J., Ramsdell, J.S., 2005. Effects of marine algal toxins on thermoregulation in mice. Neurotoxicol. Teratol. 27, 727-731.

Gordon, C.J., Yang, Y., Ramsdell, J.S., 1998. Behavioral thermoregulatory response to maitotoxin in mice. Toxicon 36, 1341-1347.

Goto, A., Fujiwara, K., Kawai, A., Kawai, H., Suzuki, T., 2007. Synthesis of the EF-ring of ciguatoxin 3C based on the [2,3]-Wittig rearrangement and ring-closing olefin metathesis. Org. Lett. 9, 5373-5376.

Gregory, R.B., Barritt, G.J., 2003. Evidence that Ca2+-release-activated Ca2+ channels in rat hepatocytes are required for the maintenance of hormone-induced Ca2+ oscillations. Biochem. J. 370, 695-702.

Gregory, R.B., Rychkov, G., Barritt, G.J., 2001. Evidence that 2-aminoethyl diphenylborate is a novel inhibitor of store-operated Ca2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors. Biochem. J. 354, 285-290.

Gregory, R.B., Sykiotis, D., Barritt, G.J., 2003. Evidence that store-operated Ca2+ channels are more effective than intracellular messenger-activated non-selective cation channels in refilling rat hepatocyte intracellular Ca2+ stores. Cell Calcium 34, 241-251.

Grzebyk, D., Berland, B., Thomassin, B.A., Bosi, C., Arnoux, A., 1994. ECOLOGY OF CIGUATERIC DINOFLAGELLATES IN THE CORAL-REEF COMPLEX OF MAYOTTE ISLAND (SW INDIAN-OCEAN). J. Exp. Mar. Biol. Ecol. 178, 51-66.

Guingab-Cagmat, J.D., Newsom, K., Vakulenko, A., Cagmat, E.B., Kobeissy, F.H., Zoltewicz, S., Wang, K.K., Anagli, J., 2012. In vitro MS-based proteomic analysis and absolute quantification of neuronal-glial injury biomarkers in cell culture system. Electrophoresis 33, 3786-3797.

Gusovsky, F., Bitran, J.A., Yasumoto, T., Daly, J.W., 1990. MECHANISM OF MAITOTOXIN-STIMULATED PHOSPHOINOSITIDE BREAKDOWN IN HL-60 CELLS. J. Pharmacol. Exp. Ther. 252, 466-473.

Gusovsky, F., Daly, J.W., 1990. MAITOTOXIN - A UNIQUE PHARMACOLOGICAL TOOL FOR RESEARCH ON CALCIUM-DEPENDENT MECHANISMS. Biochem. Pharmacol. 39, 1633-1639.

Gusovsky, F., Daly, J.W., Yasumoto, T., Rojas, E., 1988. DIFFERENTIAL-EFFECTS OF MAITOTOXIN ON ATP SECRETION AND ON PHOSPHOINOSITIDE BREAKDOWN IN RAT PHEOCHROMOCYTOMA CELLS. FEBS Lett. 233, 139-142.

Gusovsky, F., Lueders, J.E., Kohn, E.C., Felder, C.C., 1993. MUSCARINIC RECEPTOR-MEDIATED TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE C-GAMMA - AN ALTERNATIVE MECHANISM FOR CHOLINERGIC-INDUCED PHOSPHOINOSITIDE BREAKDOWN. J. Biol. Chem. 268, 7768-7772.

Gusovsky, F., Yasumoto, T., Daly, J.W., 1987. MAITOTOXIN STIMULATES PHOSPHOINOSITIDE BREAKDOWN IN NEURO-BLASTOMA HYBRID NCB-20 CELLS. Cellular and Molecular Neurobiology 7, 317-322.

Gusovsky, F., Yasumoto, T., Daly, J.W., 1989. CALCIUM-DEPENDENT EFFECTS OF MAITOTOXIN ON PHOSPHOINOSITIDE BREAKDOWN AND ON CYCLIC-AMP ACCUMULATION IN PC12 AND NCB-20 CELLS. Mol. Pharmacol. 36, 44-53.

Gusovsky, F., Yasumoto, T., Daly, J.W., 1989. MAITOTOXIN, A POTENT, GENERAL ACTIVATOR OF PHOSPHOINOSITIDE BREAKDOWN. FEBS Lett. 243, 307-312.

Gutierrez, D., deLeon, L.D., Vaca, L., 1997. Characterization of the maitotoxin-induced calcium influx pathway from human skin fibroblasts. Cell Calcium 22, 31-38.

H.P., v.E., G.J.A., S., 1990. Food Contaminants - naturally occurring toxicants in foodstuffs 3. Phycotoxins. Food Laboratory News 22, 41-49.

Habermehl, G.G., Krebs, H.C., Rasoanaivo, P., Ramailiharisoa, A., 1994. Severe ciguatera poisoning in madagascar: A case report. Toxicon [Toxicon] 32, 1539-1542.

Habermehl, G.G., Krebs, H.C., Rasoanaivo, P., Ramialiharisoa, A., 1994. SEVERE CIGUATERA POISONING IN MADAGASCAR - A CASE-REPORT. Toxicon 32, 1539-1542.

Hagelstein, J.-G.H., Jacobs, P., Vuksanovic, M., 1991. Ciguatera - ein Problem in der Schiffahrts- und Touristikmedizin. Wehrmed. Mschr. 5, 226-229.

Hahn, S.T., Capra, M.F., 1992. The cyanobacterium Oscillatoria erythraea--a potential source of toxin in the ciguatera food-chain. Food Addit Contam 9, 351-355.

Hahn, S.T., Capra, M.F., 1992. THE CYANOBACTERIUM OSCILLATORIA-ERYTHRAEA - A POTENTIAL SOURCE OF TOXIN IN THE CIGUATERA FOOD-CHAIN. Food Addit. Contam. 9, 351-355.

Hahn, S.T., Capra, M.F., Walsh, T.P., 1992. CIGUATOXIN PROTEIN ASSOCIATION IN SKELETAL-MUSCLE OF SPANISH MACKEREL (SCOMBEROMORUS-COMMERSONI). Toxicon 30, 843-852.

Hahn, S.T., Capra, M.F., Walsh, T.P., 1992. Ciguatoxin-protein association in skeletal muscle of spanish mackerel (Scomberomorus commersoni). Toxicon [Toxicon] 30, 843-852.

Hajimohammadreza, I., Raser, K.J., Nath, R., Nadimpalli, R., Scott, M., Wang, K.K.W., 1997. Neuronal nitric oxide synthase and calmodulin-dependent protein kinase II alpha undergo neurotoxin-induced proteolysis. J. Neurochem. 69, 1006-1013.

Hales, S., Weinstein, P., Woodward, A., 1999. Ciguatera (fish poisoning), El Nino, and Pacific sea surface temperatures. Ecosystem Health 5, 20-25.

Halstead, B.W., 2002. The microbial biogenesis of aquatic biotoxins. Toxicology Mechanisms and Methods 12, 135-153.

Halwachs, S., Kneuer, C., Honscha, W., 2007. Downregulation of the reduced folate carrier transport activity by phenobarbital-type cytochrome P450 inducers and protein kinase C activators. Biochim. Biophys. Acta-Biomembr. 1768, 1671-1679.

Hamajima, A., Isobe, M., 2006. Convergent synthesis of the right-hand segment of ciguatoxin. Org. Lett. 8, 1205-1208.

Hamajima, A., Isobe, M., 2009. Total synthesis of ciguatoxin. Angew Chem Int Ed Engl 48, 2941-2945.

Hamamoto, Y., Tachibana, K., Holland, P.T., Shi, F., Beuzenberg, V., Itoh, Y., Satake, M., 2012. Brevisulcenal-F: A Polycyclic Ether Toxin Associated with Massive Fish-kills in New Zealand. J. Am. Chem. Soc. 134, 4963-4968.

Hamblin, P.A., McLachlan, E.M., Lewis, R.J., 1995. SUB NANOMOLAR CONCENTRATIONS OF CIGUATOXIN-1 EXCITE PREGANGLIONIC TERMINALS IN GUINEA-PIG SYMPATHETIC-GANGLIA. Naunyn-Schmiedebergs Arch. Pharmacol. 352, 236-246.

Hamilton, B., Hurbungs, M., Jones, A., Lewis, R.J., 2002. Multiple ciguatoxins present in Indian Ocean reef fish. Toxicon 40, 1347-1353.

Hamilton, B., Hurbungs, M., Vernoux, J.P., Jones, A., Lewis, R.J., 2002. Isolation and characterisation of Indian Ocean ciguatoxin. Toxicon 40, 685-693.

Hamilton, B., Whittle, N., Shaw, G., Eaglesham, G., Moore, M.R., Lewis, R.J., 2010. Human fatality associated with Pacific ciguatoxin contaminated fish. Toxicon 56, 668-673.

Haque, S.M., Onoue, Y., 2002. Variation in toxin compositions of two harmful raphidophytes, Chattonella antiqua and Chattonella marina, at different salinities. Environ. Toxicol. 17, 113-118.

Hardison, D.R., Holland, W.C., McCall, J.R., Bourdelais, A.J., Baden, D.G., Darius, H.T., Chinain, M., Tester, P.A., Shea, D., Quintana, H.A.F., Morris, J.A., Litaker, R.W., 2016. Fluorescent Receptor Binding Assay for Detecting Ciguatoxins in Fish. PLoS One 11.

Harrison, S., Reddy, S., Page, C.P., Spina, D., 1998. Stimulation of airway sensory nerves by cyclosporin A and FK506 in guinea-pig isolated bronchus. Br. J. Pharmacol. 125, 1405-1412.

Hawes, B.E., Marzen, J.E., Waters, S.B., Conn, P.M., 1992. SODIUM-FLUORIDE PROVOKES GONADOTROPE DESENSITIZATION TO GONADOTROPIN-RELEASING-HORMONE (GNRH) AND GONADOTROPE SENSITIZATION TO A23187 - EVIDENCE FOR MULTIPLE G-PROTEINS IN GNRH ACTION. Endocrinology 130, 2465-2475.

Hawgood, B.J., 2002. The marine biologist - Bob Endean, 6th Asia/Pacific Congress on Animals, Plant and Microbial Toxins/11th Annual Scientific Meeting of the Australiasian-College-of-Tropical-Medicine. Pergamon-Elsevier Science Ltd, Cairns, AUSTRALIA, pp. 768-779.

Heimbecker, R.O., 1999. Ciguatera fish poisoning. Canadian Medical Association Journal 160, 1127.

Hernandez-Becerril, D.U., Becerril, A.A., 2004. Species of dinoflagellates of the genus Gambierdiscus (Dinophyceae) in the Mexican Caribbean Sea. Revista De Biologia Tropical 52, 77-87.

Hidalgo, J., Liberona, J.L., Molga, J., Legrand, A.M., Jaimovich, E., 2000. Ciguatoxin (CTX-1b) modifies intracellular Ca2+ and inositol 1,4,5-trisphosphate mass levels in rat myotubes without an apparent effect on Na+ currents. J. Physiol.-London 523, 31P-31P.

Hidalgo, J., Liberona, J.L., Molgo, J., Jaimovich, E., 2002. Pacific ciguatoxin-1b effect over Na+ and K+ currents, inositol 1,4,5-triphosphate content and intracellular Ca2+ signals in cultured rat myotubes. Br. J. Pharmacol. 137, 1055-1062.

Hirama, M., 2005. Total synthesis of ciguatoxin CTX3C: A venture into the problems of ciguatera seafood poisoning. Chem. Rec. 5, 240-250.

Hirama, M., Inoue, M., 2003. Practical total synthesis of ciguatoxin CTX3C, 225th National Meeting of the American-Chemical-Society, New Orleans, Louisiana, pp. 7-ORGN.

Hirama, M., Oishi, T., Uehara, H., Inoue, M., Maruyama, M., Guri, H., Satake, M., 2001. Total synthesis of ciguatoxin CTX3C. Science 294, 1904-1907.

Ho, A.M.H., Fraser, I.M., Todd, E.C.D., 1986. Ciguatera poisoning: A report of three cases. Annales of Emergency Medicine [Ann. Emerg. Med.] 15, 1225-1228.

Ho, K.C., 1997. Variations in the PSP contents of shellfish in Hong Kong and the eastern coast of South China Sea, 2nd International Conference on Molluscan Shellfish Safety, Iloilo, Philippines, pp. 1657-1660.

Ho, K.C., 1998. Variations in the PSP contents of shellfish in Hong Kong and the eastern coast of South China Sea. J. Shellfish Res. 17, 1657-1660.

Hoffman, P.A., Granade, H.R., McMillan, J.P., 1983. THE MOUSE CIGUATOXIN BIOASSAY - A DOSE-RESPONSE CURVE AND SYMPTOMATOLOGY ANALYSIS. Toxicon 21, 363-369.

Hogg, R.C., Lewis, R.J., Adams, D.J., 1998. Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones. Neurosci. Lett. 252, 103-106.

Hogg, R.C., Lewis, R.J., Adams, D.J., 2002. Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons. Eur. J. Neurosci. 16, 242-248.

Hokama, Y., 1985. A RAPID, SIMPLIFIED ENZYME-IMMUNOASSAY STICK TEST FOR THE DETECTION OF CIGUATOXIN AND RELATED POLYETHERS FROM FISH-TISSUES. Toxicon 23, 939-946.

Hokama, Y., 1990. IMMUNOLOGICAL STUDIES USING MONOCLONAL-ANTIBODIES FOR DETECTION OF LOW DALTON MARINE TOXINS, International Symp on Workshop on Food Contamination, Mycotoxins and Phycotoxins, Cairo, Egypt, pp. 83-95.

Hokama, Y., 1990. RECENT METHODS FOR DETECTION OF SEAFOOD TOXINS - RECENT IMMUNOLOGICAL METHODS FOR CIGUATOXIN AND RELATED POLYETHERS, International Symp on Workshop on Food Contamination, Mycotoxins and Phycotoxins, Cairo, Egypt, pp. 71-82.

Hokama, Y., 1990. SIMPLIFIED SOLID-PHASE IMMUNOBEAD ASSAY FOR DETECTION OF CIGUATOXIN AND RELATED POLYETHERS. J. Clin. Lab. Anal. 4, 213-217.

Hokama, Y., 1991. IMMUNOLOGICAL ANALYSIS OF LOW-MOLECULAR-WEIGHT MARINE TOXINS. Journal of Toxicology-Toxin Reviews 10, 1-35.

Hokama, Y., 1993. Immunological studies using monoclonal antibodies for detection of low dalton marine toxins. Food Addit. Contam. 10, 83-95.

Hokama, Y., 1993. Recent methods for detection of seafood toxins: recent immunological methods for ciguatoxin and related polyethers. Food Addit. Contam. 10, 71-82.

Hokama, Y., Abad, M.A., Kimura, L.H., 1983. A rapid enzyme-immunoassay for the detection of ciguatoxin in contaminated fish tissues. Toxicon [Toxicon] 21, 817-824.

Hokama, Y., Abad, M.A., Kimura, L.H., 1983. A RAPID ENZYME-IMMUNOASSAY FOR THE DETECTION OF CIGUATOXIN IN CONTAMINATED FISH-TISSUES. Toxicon 21, 817-824.

Hokama, Y., Abad, M.A., Shirai, L.K., Hino, W., Kimura, L., 1985. EVALUATION OF THE ENZYME-IMMUNOASSAY FOR THE DETECTION OF CIGUATOXIN FROM FISH TISSUE. Toxicon 23, 30-30.

Hokama, Y., Asahina, A.Y., Shang, E.S., Hong, T.W.P., Shirai, J.L.R., 1993. EVALUATION OF THE HAWAIIAN REEF FISHES WITH THE SOLID-PHASE IMMUNOBEAD ASSAY. J. Clin. Lab. Anal. 7, 26-30.

Hokama, Y., Asahina, A.Y., Titus, E., Shirai, J.L.R., Hong, T.W.P., Chun, S., Miyahara, J.T., Takata, D., Muranaka, A., Pang, E., Abbott, I.A., Ichinotsubo, D., 1993. A SURVEY OF CIGUATERA - ASSESSMENT OF PUAKO, HAWAII, ASSOCIATED WITH CIGUATERA TOXIN EPIDEMICS IN HUMANS. J. Clin. Lab. Anal. 7, 147-154.

Hokama, Y., Banner, A., Boylan, D., 1977. A radioimmunoassay for the detection of ciguatoxin. Toxicon [Toxicon] 15, 317-325.

Hokama, Y., Banner, A.H., Boylan, D.B., 1977. RADIOIMMUNOASSAY FOR DETECTION OF CIGUATOXIN. Toxicon 15, 317-&.

Hokama, Y., Chun, K.E., Campora, C.E., Higa, N., Suma, C., Hamajima, A., Isobe, M., 2006. Biological activity of the functional epitope of ciguatoxin fragment AB on the neuroblastoma sodium channel in tissue culture. J. Clin. Lab. Anal. 20, 126-132.

Hokama, Y., Ebesu, J.S.M., Nishimura, K., Oishi, S., Mizuo, B., Stiles, M., Sakamoto, B., Takenaka, W., Nagai, H., 1996. Human intoxications from Hawaiian reef fishes associated with diverse marine toxins. Journal of Natural Toxins 5, 235-247.

Hokama, Y., Empey-Campora, C., Hara, C., Higa, N., Siu, N., Lau, R., Kuribayashi, T., Yabusaki, K., 2008. Acute phase phospholipids related to the cardiolipin of mitochondria in the sera of patients with chronic fatigue syndrome (CFS), chronic Ciguatera fish poisoning (CCFP), and other diseases attributed to chemicals, Gulf War, and marine toxins. J. Clin. Lab. Anal. 22, 99-105.

Hokama, Y., Honda, S.A.A., Asahina, A.Y., Fong, J.M.L., Matsumoto, C.M., Gallacher, T.S., 1989. Cross-reactivity of ciguatoxin, okadaic acid, and polyethers with monoclonal antibodies. Food Agric. Immunol 1, 29-35.

Hokama, Y., Honda, S.A.A., Kobayashi, M.N., Mah, K.L., Nakagawa, L.K., Kang, K.M., Kurihara, J.E., Miyahara, J.T., 1988. MONOCLONAL-ANTIBODIES IN THE DETECTION OF CIGUATOXIN (CTX) AND RELATED POLYETHERS IN CONTAMINATED FISH-TISSUES. Toxicon 26, 25-25.

Hokama, Y., Honda, S.A.A., Kobayashi, M.N., Nakagawa, L.K., Shirai, L.K., Miyahara, J.T., 1988. Monoclonal antibodies (monoAbs) to ciguatoxin and related polyethers. Lect. Notes Coastal Estuarine Stud 25, 155-166.

Hokama, Y., Hong, T.W., Isobe, M., Ichikawa, Y., Yasumoto, T., 1992. Cross-reactivity of highly purified okadaic acid (OA), synthetic, spiroketal East sphere of OA and ciguatoxin. J. Clin. Lab. Anal. 6, 54-58.

Hokama, Y., Hong, T.W.P., Isobe, M., Ichikawa, Y., Yasumoto, T., 1992. CROSS-REACTIVITY OF HIGHLY PURIFIED OKADAIC ACID (OA), SYNTHETIC, SPIROKETAL EAST SPHERE OF OA AND CIGUATOXIN. J. Clin. Lab. Anal. 6, 54-58.

Hokama, Y., Hong, T.W.P., Shang, E., Asahina, A.Y., Shirai, J.L.R., 1993. IMMUNOASSAY FOR DETECTION OF LOW-MOLECULAR LIPID MARINE TOXINS - CIGUATOXIN AND RELATED POLYETHERS. J. Immunol. 150, A325-A325.

Hokama, Y., Kimura, L.H., Abad, M.A., Yokochi, L., Scheuer, P.J., Nukina, M., Yasumoto, T., Baden, D.G., Shimizu, Y., 1984. AN ENZYME-IMMUNOASSAY FOR THE DETECTION OF CIGUATOXIN - AND COMPETITIVE-INHIBITION BY RELATED NATURAL POLYETHER TOXINS. Acs Symposium Series 262, 307-320.

Hokama, Y., M., S.H., Kobayashi, L., Nakagawa, J., Kurihara, Miyahara, J., 1987. Monoclonal antibodies in the detection of ciguatera (CTX) and related polyethers in contaminated fish tissues, in: Gopalakrishnakone, P., Tan, C.K. (Eds.), Progress in Venom and Toxin Research, Proc. of the First Asia-Pacific Congress on Animal, Plant and Microbial Toxins

Gopalakrishnakone. Faculty of Medicine, University of Singapore, Singapore, pp. 385-393.

Hokama, Y., Nishimura, K., Takenaka, W., Ebesu, J.S.M., 1998. Simplified solid-phase membrane immunobead assay (MIA) with monoclonal anti-ciguatoxin antibody (MAb-CTX) for detection of ciguatoxin and related polyether toxins. J. Nat. Toxins 7, 1-21.

Hokama, Y., Nishimura, K.L., Takenaka, W.E., Ebesu, J.S.M., 1996. Latex Antibody Test (LAT) for detection of marine toxins in ciguateric fish, 13th Rocky Mountain Regional ACS Meeting, Lakewood, Co, pp. 35-50.

Hokama, Y., Nishimura, K.L., Takenaka, W.E., Ebesu, J.S.M., 1997. Latex Antibody Test (LAT) for detection of marine toxins in ciguateric fish. Journal of Natural Toxins 6, 35-50.

Hokama, Y., Okubo, C.M., Cripps, C., Matsukawa, L.A., Kimura, L.H., 1980. THE EFFECT OF PURIFIED CIGUATOXIN ON MITOGEN RESPONSES OF MOUSE SPLEEN LYMPHOID-CELLS. Research Communications in Chemical Pathology and Pharmacology 29, 397-400.

Hokama, Y., Scheuer, P.J., Yasumoto, T., 1983. AN ENZYME-IMMUNOASSAY FOR THE DETECTION OF CIGUATOXIN. Abstracts of Papers of the American Chemical Society 186, 138-AGFD.

Hokama, Y., Scheuer, P.J., Yasumoto, T., 1995. Proceedings of the International Symposium on Ciguatera and Marine Natural Products. Asian-Pacific Research Foundation, Honolulu, Hawaii.

Hokama, Y., Scheuer, P.J., Yasumoto, T., 1995. Proceedings of the International Symposium on Ciguatera and Marine Natural Products; Aug. 8-10, 1994; Honolulu, Hawaii. Asian-Pacific Research Foundation, Honolulu, Hawaii, p. 309 pp.

Hokama, Y., Shirai, J.L., Islam, M.A., 1994. EVALUATION OF BIOASSAY FOR TOXICITY OF CIGUATERIC FISH AND ASSOCIATED TOXINS. J. Clin. Lab. Anal. 8, 63-69.

Hokama, Y., Shirai, L.K., Iwamoto, L.M., Kobayashi, M.N., Goto, C.S., Nakagawa, L.K., 1987. ASSESSMENT OF A RAPID ENZYME-IMMUNOASSAY STICK TEST FOR THE DETECTION OF CIGUATOXIN AND RELATED POLYETHER TOXINS IN FISH-TISSUES. Biol. Bull. 172, 144-153.

Hokama, Y., Shiraki, L.W., Iwamoto, M., Kobayashi, M.N., Goto, C.S., Nakagawa, L.K., 1987. Assessment of a rapid enzyme immunoassay stick test for the detection of ciguatoxin and related polyether toxins in fish tissues. Biological Bulletin [Biol. Bull.] 172, 144-153.

Hokama, Y., Siu, N., Kuribayashi, T., Higa, N., Suma, C., Empey-Campora, C., Chun, K., Yabusaki, K., 2006. Antigenic similarity of abnormal lipids in chronic fatigue syndrome (CFS) and chronic Ciguatera fish poisoning (CCFP) sera and a homologous antibody to the lipids resembling an epitope of ciguatoxin, Experimental Biology 2006 Meeting. Federation Amer Soc Exp Biol, San Francisco, CA, pp. A1102-A1102.

Hokama, Y., Takenaka, W.E., Nishimura, K.L., Ebesu, J.S.M., Bourke, R., Sullivan, P.K., 1998. A simple membrane immunobead assay for detecting ciguatoxin and related polyethers from human ciguatera intoxication and natural reef fishes. J.AOAC Int. 81, 727-735.

Hokama, Y., Uto, G.A., Palafox, N.A., Enlander, D., Jordan, E., Cocchetto, A., 2003. Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX. J. Clin. Lab. Anal. 17, 132-139.

Hokama, Y., Wachi, K.M., Shiraki, A., Goo, C., Ebesu, J.S.M., 2001. The biological assessment of flora and fauna as standards for changes in the near-shore ocean environment: A study of Barbers Point Harbor. Journal of Natural Toxins 10, 57-68.

Hokama, Y., Whang, C., Chun, K.F., Suma, C., Higa, N., Or, B.F.W., Cocchetto, A., Kansky, G., 2002. Chronic phase lipids in sera of several chronic diseases reacting with MAB-CTX (antibody to ciguatoxin), International Symposium on Toxins and Natural Products in Honor of Professor Anthony T Yu, Okinawa, Japan, pp. 547-554.

Hokama, Y., Yoshikawa-Ebesu, J.S.M., 2001. Ciguatera fish poisoning: A foodborne disease. Journal of Toxicology-Toxin Reviews 20, 85-139.

Holland, W.C., Litaker, R.W., Tomas, C.R., Kibler, S.R., Place, A.R., Davenport, E.D., Tester, P.A., 2013. Differences in the toxicity of six Gambierdiscus (Dinophyceae) species measured using an in vitro human erythrocyte lysis assay. Toxicon 65, 15-33.

Holmes, M.J., 1998. Gambierdiscus yasumotoi sp. nov. (Dinophyceae), a toxic benthic dinoflagellate from southeastern Asia. J. Phycol. 34, 661-668.

Holmes, M.J., Brust, A., Lewis, R.J., 2014. Dinoflagellate Toxins, Seafood and Freshwater Toxins. CRC Press, pp. 3-38.

Holmes, M.J., Lewis, R.J., 1994. Purification and characterisation of large and small maitotoxins from cultured gambierdiscus toxicus. Natural Toxins 2, 64-72.

Holmes, M.J., Lewis, R.J., Gillespie, N.C., 1990. TOXICITY OF AUSTRALIAN AND FRENCH-POLYNESIAN STRAINS OF GAMBIERDISCUS-TOXICUS (DINOPHYCEAE) GROWN IN CULTURE - CHARACTERIZATION OF A NEW TYPE OF MAITOTOXIN. Toxicon 28, 1159-1172.

Holmes, M.J., Lewis, R.J., Poli, M.A., Gillespie, N.C., 1991. STRAIN DEPENDENT PRODUCTION OF CIGUATOXIN PRECURSORS (GAMBIERTOXINS) BY GAMBIERDISCUS-TOXICUS (DINOPHYCEAE) IN CULTURE. Toxicon 29, 761-775.

Holmes, M.J., Teo, S.L.M., 2002. Toxic marine dinoflagellates in Singapore waters that cause seafood poisonings. Clinical and Experimental Pharmacology and Physiology 29, 829-836.

Holton, R.A., BouHamdan, F.R., 2006. Biomimetic cascade reactions towards the synthesis of ciguatoxin, 231st National Meeting of the American-Chemical-Society. Amer Chemical Soc, Atlanta, GA, pp. 485-ORGN.

Holz, G.G., Leech, C.A., Habener, J.F., 2000. Insulinotropic toxins as molecular probes for analysis of glucagon-like peptide-1 receptor-mediated signal transduction in pancreatic beta-cells. Biochimie 82, 915-926.

Hong, J., Talapatra, S., Katz, J., Tester, P.A., Waggett, R.J., Place, A.R., 2012. Algal Toxins Alter Copepod Feeding Behavior. PLoS One 7, e36845.

Hong, T.W.P., Salter, R.C., Ebesu, J.S.M., Hokama, Y., 1994

1995. Evaluation of Caranx sp. (Jack family) by the stick enzyme immunoassay (S-EIA) for ciguatera, in: Hokama, Y., Scheuer, P.J., Yasumoto, T. (Eds.), Proceedings of the International Symposium on Ciguatera and Marine Natural Products. Asian-Pacific Research Foundation, Honolulu, Hawaii, pp. 137-143.

Hoshi, M., Amano, T., Okita, Y., Okinaga, T., Matsui, T., 1990. EGG SIGNALS FOR TRIGGERING THE ACROSOME REACTION IN STARFISH SPERMATOZOA. Journal of Reproduction and Fertility, 23-31.

Hosokawa, S., Isobe, M., 1995. SYNTHESIS OF 2 DIASTEREOISOMERS OF A/B-FRAGMENT OF CIGUATOXIN. Synlett, 1179-1180.

Hosokawa, S., Isobe, M., 1996. Partial synthesis of ciguatoxin, an A/B/C fragment. Synlett, 351-352.

Hosokawa, S., Isobe, M., 1999. Mirror image synthesis of left ends of ciguatoxin and gambiertoxin 4B. J. Org. Chem. 64, 37-48.

Hossen, V., Soliño, L., Leroy, P., David, E., Velge, P., Dragacci, S., Krys, S., Flores Quintana, H., Diogène, J., 2015. Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies). Environ. Res. 143, Part B, 100-108.

Hoye, T.R., Tennakoon, M.A., 2000. Synthesis (and alternative proof of configuration) of the scyphostatin C(1 ')-C(20 ') trienoyl fragment. Org. Lett. 2, 1481-1483.

Hsieh, C.H., Hwang, K.L., Lee, M.M., Lan, C.H., Lin, W.F., Hwang, D.F., 2009. Species Identification of Ciguatoxin-Carrying Grouper Implicated in Food Poisoning. Journal of Food Protection 72, 2375-2379.

Hsieh, C.-H., Lin, W.-F., Hwang, D.-F., Lan, C.-H., Hwang, K.-L., Lee, M.-M., 2009. Species Identification of Ciguatoxin-Carrying Grouper Implicated in Food Poisoning. Journal of food protection 72, 2375-2379.

Hung, Y.M., Hung, S.Y., Chou, K.J., Huang, N.C., Tung, C.N., Hwang, D.F., Chung, H.M., 2005. Short report: Persistent bradycardia caused by ciguatoxin poisoning after barracuda fish eggs ingestion in southern Taiwan. Am. J. Trop. Med. Hyg. 73, 1026-1027.

Huss, H.H., 2002. Safety aspects associated with preharvest conditions of aquatic food products. Wageningen Academic Publishers, Wageningen.

Huss, H.H., Reilly, A., Ben Embarek, P.K., 2000. Prevention and control of hazards in seafood. Food Control 11, 149-156.

Hwang, D.F., 2002. Research on marine toxins in Taiwan, International Symposium on Toxins and Natural Products in Honor of Professor Anthony T Yu, Okinawa, Japan, pp. 663-678.

Hwang, D.F., 2003. Research on marine toxins in Taiwan. Journal of Toxicology-Toxin Reviews 22, 663-678.

Hwang, D.F., Lu, Y.H., 2000. Influence of environmental and nutritional factors on growth, toxicity, and toxin profile of dinoflagellate Alexandrium minutum. Toxicon 38, 1491-1503.

Igarashi, T., Aritake, S., Yasumoto, T., 1999. Mechanisms underlying the hemolytic and ichthyotoxic activities of maitotoxin. Natural Toxins 7, 71-79.

Igarashi, T., Satake, M., Yasumoto, T., 1999. Structures and partial stereochemical assignments for prymnesin-1 and prymnesin-2: Potent hemolytic and ichthyotoxic glycosides isolated from the red tide alga Prymnesium parvum. J. Am. Chem. Soc. 121, 8499-8511.

Ikeda, H., Matsumori, N., Ono, M., Suzuki, A., Isogai, A., Nagasawa, H., Sakuda, S., 2000. Absolute configuration of aflastatin A, a specific inhibitor of aflatoxin production by Aspergillus parasiticus. J. Org. Chem. 65, 438-444.

Imai, H., Uehara, H., Inoue, M., Oguri, H., Oishi, T., Hirama, M., 2001. Convergent synthesis of the EFGH ring fragment of ciguatoxin CTX3C. Tetrahedron Lett. 42, 6219-6222.

Inoue, M., 2004. Convergent syntheses of polycyclic ethers. Illustrations of the utility of acetal-linked intermediates. Org. Biomol. Chem. 2, 1811-1817.

Inoue, M., Hirama, M., 2004. Evolution of a practical total synthesis of ciguatoxin CTX3C. Accounts of Chemical Research 37, 961-968.

Inoue, M., Hirama, M., 2004. Total synthesis of ciguatoxin CTX3C, a causative toxin of ciguatera seafood poisoning. Synlett, 577-595.

Inoue, M., Hirama, M., Satake, M., Sugiyama, K., Yasumoto, T., 2003. Inhibition of brevetoxin binding to the voltage-gated sodium channel by gambierol and gambieric acid-A. Toxicon 41, 469-474.

Inoue, M., Ishihara, Y., Yamashita, S., Hirama, M., 2006. Convergent assembly of polycyclic ethers via acyl radical addition to unactivated enol ether. Org. Lett. 8, 5801-5804.

Inoue, M., Iwatsu, M., Yamashita, S., Hirama, M., 2007. A concise route to two distinct E-ring structures of ciguatoxins. Heterocycles 72, 327-338.

Inoue, M., Lee, N., Miyazaki, K., Usuki, T., Matsuoka, S., Hirama, M., 2008. Critical Importance of the Nine-Membered F Ring of Ciguatoxin for Potent Bioactivity: Total Synthesis and Biological Evaluation of F-Ring-Modified Analogues. Angew. Chem.-Int. Edit. 47, 8611-8614.

Inoue, M., Lee, N., Tsumuraya, T., Fujii, I., Hirama, M., 2009. Use of monoclonal antibodies as an effective strategy for treatment of ciguatera poisoning. Toxicon 53, 802-805.

Inoue, M., Miyazaki, K., Ishihara, Y., Tatami, A., Ohnuma, Y., Kawada, Y., Komano, K., Yamashita, S., Lee, N., Hirama, M., 2006. Total synthesis of ciguatoxin and 51-hydroxyCTX3C. J. Am. Chem. Soc. 128, 9352-9354.

Inoue, M., Miyazaki, K., Uehara, H., Maruyama, M., Hirama, M., 2004. First- and second-generation total synthesis of ciguatoxin CTX3C. Proc. Natl. Acad. Sci. U. S. A. 101, 12013-12018.

Inoue, M., Saito, F., Iwatsu, M., Ishihara, Y., Hirama, M., 2007. Convergent synthesis of the ABCDE-ring fragment of the Caribbean ciguatoxin C-CTX-1. Tetrahedron Lett. 48, 2171-2175.

Inoue, M., Sasaki, M., Tachibana, K., 1997. Construction of fused oxonene ring and reproduction of conformational behavior shown by ring F of ciguatoxin. Tetrahedron Lett. 38, 1611-1614.

Inoue, M., Sasaki, M., Tachibana, K., 1998. Synthetic studies on ciguatoxin: A convergent strategy for construction of the F-M ring framework. Angew. Chem.-Int. Edit. 37, 965-969.

Inoue, M., Sasaki, M., Tachibana, K., 1999. A convergent synthesis of the decacyclic ciguatoxin model containing the F-M ring framework. J. Org. Chem. 64, 9416-9429.

Inoue, M., Sasaki, M., Tachibana, K., 1999. A convergent synthesis of the trans-fused hexahydrooxonine ring system and reproduction of conformational behavior shown by ring F of ciguatoxin. Tetrahedron 55, 10949-10970.

Inoue, M., Uehara, H., Maruyama, M., Hirama, M., 2002. Practical total synthesis of ciguatoxin CTX3C by improved protective group strategy. Org. Lett. 4, 4551-4554.

Inoue, M., Xing, G., Wang, X., Wang, J., Hirama, M., 2002. Novel assembly of cyclic ethers by coupling alpha-chlorosulfides and alcohols. Org. Lett. 4, 3439-3442.

Inoue, M., Yamashita, S., Ishihara, Y., Hirama, M., 2006. Two convergent routes to the left-wing fragment of ciguatoxin CTX3C using O,S-acetals as key intermediates. Org. Lett. 8, 5805-5808.

Inoue, M., Yamashita, S., Tatami, A., Miyazaki, K., Hirama, M., 2004. A new stereoselective synthesis of ciguatoxin right wing fragments. J. Org. Chem. 69, 2797-2804.

Irving, A.M., 1999. Ciguatera fish poisoning. Canadian Medical Association Journal 160, 1127.

Isbister, G.K., Kiernan, M.C., 2005. Neurotoxic marine poisoning. Lancet Neurology 4, 219-228.

Ishihara, Y., Lee, N., Oshiro, N., Matsuoka, S., Yamashita, S., Inoue, M., Hirama, M., 2010. The first F-ring modified ciguatoxin analogue showing significant toxicity. Chem. Commun. 46, 2968-2970.

Ishihara, Y., Miyazaki, K., Yamashita, S., Hirama, M., 2009. Remarkable Selectivity in Derivatization and Protection of Hydroxy Groups of 51-hydroxyCTX3C: Chemoselective Synthesis of Biotin-conjugated Ciguatoxin Derivatives. Chem. Lett. 38, 886-887.

Isobe, M., Hamajima, A., 2010. Ciguatoxin: developing the methodology for total synthesis. Nat. Prod. Rep. 27, 1204-1226.

Isobe, M., Hosokawa, S., Kira, K., 1996. syn-trans fused bicyclic ether formation via acetylene-biscobalthexacarbonyl complex. Chem. Lett., 473-474.

Isobe, M., Kira, K., 2000. New synthesis with acetylene biscobalthexacarbonyl complex (2). J. Synth. Org. Chem. Jpn. 58, 99-107.

Isobe, M., Tsuboi, K., Hosokawa, S., Bamba, M., Kira, K., Shibuya, S., Ohtani, II, Nishikawa, T., Ichikawa, Y., 1996. Enzyme inhibitors, synthesis and approach to mechanism, 11th International Conference on Organic Synthesis, Amsterdam, Netherlands, pp. 401-406.

Ito, E., Suzuki-Toyota, F., Toshimori, K., Fuwa, H., Tachibana, K., Satake, M., Sasaki, M., 2003. Pathological effects on mice by gambierol, possibly one of the ciguatera toxins. Toxicon 42, 733-740.

Ito, E., Yasumoto, T., Terao, K., 1996. Morphological observations of diarrhea in mice caused by experimental ciguatoxicosis. Toxicon 34, 111-122.

Ivin, K.J., 1997. Some recent applications of olefin metathesis in organic synthesis: A review, 12th International Symposium on Metathesis and Related Chemistry, St Augustine, Florida, pp. 1-16.

Ivin, K.J., 1998. Some recent applications of olefin metathesis in organic synthesis: A review. Journal of Molecular Catalysis a-Chemical 133, 1-16.

Iwaoka, W., Horita, J., Shimojo, R., Tran, T., 1992. ANALYSIS OF ACANTHURUS-TRIOSTEGUS FOR MARINE TOXINS BY THE STICK ENZYME-IMMUNOASSAY AND MOUSE BIOASSAY. Toxicon 30, 1575-1581.

J.D., F., 1997. Extraction of ciguatoxins from fish: a review of methodologies. The IOC-IEO Science and Communication Centre on Harmful Algae Vigo, Spain manuscript.

J.M., B., 1999. The lurking perils of Pfiesteria. Scientific American August, 28-35.

Jacobs, M.F., Kitching, W., 1998. Spiroacetals of marine origin. CURRENT-ORGANIC-CHEMISTRY 2, 395-436.

Jacobson, E.R., Homer, B.L., Stacy, B.A., Greiner, E.C., Szabo, N.J., Chrisman, C.L., Origgi, F., Coberley, S., Foley, A.M., Landsberg, J.H., Flewelling, L., Ewing, R.Y., Moretti, R., Schaf, S., Rose, C., Mader, D.R., Harman, G.R., Manire, C.A., Mettee, N.S., Mizisin, A.P., Shelton, G.D., 2006. Neurological disease in wild loggerhead sea turtles Caretta caretta. Dis. Aquat. Org. 70, 139-154.

Janovick, J.A., Natarajan, K., Longo, F., Conn, P.M., 1991. CALDESMON - A BIFUNCTIONAL (CALMODULIN AND ACTIN) BINDING-PROTEIN WHICH REGULATES STIMULATED GONADOTROPIN-RELEASE. Endocrinology 129, 68-74.

Jiang, X.W., Li, X.M., Lam, P.K.S., Cheng, S.H., Schlenk, D., de Mitcheson, Y.S., Li, Y., Gu, J.D., Chan, L.L., 2012. Proteomic analysis of hepatic tissue of ciguatoxin (CTX) contaminated coral reef fish Cephalopholis argus and moray eel Gymnothorax undulatus. Harmful Algae 13, 65-71.

Jiang, X.-W., Li, X., Lam, P.K.S., Cheng, S.H., Schlenk, D., de Mitcheson, Y.S., Li, Y., Gu, J.-D., Chan, L.L., 2012. Proteomic analysis of hepatic tissue of ciguatoxin (CTX) contaminated coral reef fish Cephalopholis argus and moray eel Gymnothorax undulatus. Harmful Algae 13, 65-71.

Judd, A.M., Macleod, R.M., 1991. DOPAMINE RECEPTOR AND ADRENOCEPTOR AGONISTS INHIBIT PROLACTIN-RELEASE FROM MMQ CELLS. Eur. J. Pharmacol. 195, 101-106.

Judd, A.M., Macleod, R.M., 1992. THE REGULATION OF INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR RELEASE FROM PRIMARY CULTURES OF OVARIAN-CELLS. Progress in Neuroendocrinimmunology 5, 245-255.

Juranovic, L.R., Park, D.L., 1991. Foodborne toxins of marine origin: ciguatera. Rev. Environ. Contam. Toxicol. 117, 51-94.

Kadota, I., Abe, T., Uni, M., Takamura, H., Yamamoto, Y., 2008. A cross-metathesis approach to the stereocontrolled synthesis of the AB ring segment of ciguatoxin. Tetrahedron Lett. 49, 3643-3647.

Kadota, I., Sato, Y., Fujita, N., Takamura, H., Yamamoto, Y., 2015. Convergent synthesis of the EFGH ring system of ciguatoxin CTX3C. Tetrahedron 71, 6547-6558.

Kadota, I., Takamura, H., 2007. Total synthesis of brevetoxin B. J. Synth. Org. Chem. Jpn. 65, 430-438.

Kakizaki, A., Takahashi, M., Akagi, H., Tachikawa, E., Yamamoto, T., Taira, E., Yamakuni, T., Ohizumi, Y., 2006. Ca2+ channel activating action of maitotoxin in cultured brainstem neurons. Eur. J. Pharmacol. 536, 223-231.

Kakizaki, A., Yamakuni, T., Oka, N., Kitazawa, M., Tachikawa, E., Taira, E., Miyate, Y., Takahashi, K., Yamamoto, T., Tojyo, Y., Ohizumi, Y., 2006. V-1, a novel regulatory protein of TH gene expression, serves as a cytoplasmic anchoring protein of CapZ to promote F-actin formation, resulting in the enhancement of maitotoxin-induced catecholamine secretion in PC12D cells. J. Pharmacol. Sci. 100, 245P-245P.

Kalaitzis, J.A., Chau, R., Kohli, G.S., Murray, S.A., Neilan, B.A., 2010. Biosynthesis of toxic naturally-occurring seafood contaminants. Toxicon 56, 244-258.

Karalis, T., Gupta, L., Chu, M., Campbell, B.A., Capra, M.F., Maywood, P.A., 2000. Three clusters of ciguatera poisoning: clinical manifestations and public health implications. Medical Journal of Australia 172, 160-162.

Karlsson, J.O., Lundquist, J., Skoglund, I., Nilsson, M., 2000. Proteolytic activity in intact sheets of polarized epithelial cells as determined by a cell-permeable fluorogenic substrate. Cell Biol. Int. 24, 235-243.

Kasuga, F., 1999. Cell bioassay-a trial to develop new assay system for paralytic shellfish poisoning toxins (PSPs) and ciguatoxins, and comparison with other newly developed assays for PSPs. Maikotokishin (Tokyo) 48, 19-23.

Katayama, T., Conn, P.M., 1994. ACTIVIN MODULATES THE INTRACELLULAR SIGNALING SYSTEM ACTIVATED BY GONADOTROPIN-RELEASING-HORMONE - DUAL EFFECT ON CALCIUM MESSENGER SYSTEM AND PROTEIN-KINASE-C PATHWAY. Endocrinology 134, 119-125.

Katz, A.R., Terrellperica, S., Sasaki, D.M., 1993. CIGUATERA ON KAUAI - INVESTIGATION OF FACTORS ASSOCIATED WITH SEVERITY OF ILLNESS. Am. J. Trop. Med. Hyg. 49, 448-454.

Kellmann, R., Stüken, A., Orr, R.J.S., Svendsen, H.M., Jakobsen, K.S., 2010. Biosynthesis and Molecular Genetics of Polyketides in Marine Dinoflagellates. Mar. Drugs 8, 1011-1048.

Kelly, A.M., Kohler, C.C., Tindall, D.R., 1992. ARE CRUSTACEANS LINKED TO THE CIGUATERA FOOD-CHAIN. Environmental Biology of Fishes 33, 275-286.

Kemppainen, B., Avgeris, S., Jones, J.B., 2004. Field cases of feline Ciguatera. Compendium on Continuing Education for the Practicing Veterinarian 26, 132-135.

Kentaro, Y., Satsuki, S., Naomasa, O., Tsuyoshi, I., Kiminori, S., Takeshi, Y., 2014. Determination of Toxins Involved in Ciguatera Fish Poisoning in the Pacific by LC/MS. J. AOAC Int. 97, 398-402.

Kerbrat, A.S., Darius, H.T., Pauillac, S., Chinain, M., Laurent, D., 2010. Detection of ciguatoxin-like and paralysing toxins in Trichodesmium spp. from New Caledonia lagoon. Mar. Pollut. Bull. 61, 360-366.

Kerbrat, A.-S., Darius, H.T., Pauillac, S., Chinain, M., Laurent, D., 2010. Detection of ciguatoxin-like and paralysing toxins in Trichodesmium spp. from New Caledonia lagoon. Mar. Pollut. Bull. 61, 360-366.

Khan, R.N., Tall, E.G., Rebecchi, M., Ramsdell, J.S., Pentyala, S., 2001. Effect of maitotoxin on guanine nucleotide interaction with G-protein alpha subunits. International Journal of Toxicology 20, 39-44.

Kim, H.Y., Kuhn, R.J., Patkar, C., Warrier, R., Cushman, M., 2007. Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication. Bioorg. Med. Chem. 15, 2667-2679.

Kim, Y.I., Login, I.S., Yasumoto, T., 1985. MAITOTOXIN ACTIVATES QUANTAL TRANSMITTER RELEASE AT THE NEUROMUSCULAR-JUNCTION - EVIDENCE FOR ELEVATED INTRATERMINAL CA-2+ IN THE MOTOR-NERVE TERMINAL. Brain Res. 346, 357-362.

Kimura, L., Joyo, B., Shiraki, K., Sasaki, R., Hokama, Y., 1980. DETECTION OF CIGUATOXIN IN FISH-TISSUES BY RADIOIMMUNOASSAY. Federation Proceedings 39, 1141-1141.

Kimura, L.H., Abad, M.A., Hokama, Y., 1982. Evaluation of the radioimmunoassay (RIA) for detection of ciguatoxin (CTX) in fish tissues. Journal of Fish Biology [J. Fish Biol.] 21, 671-680.

Kimura, L.H., Abad, M.A., Hokama, Y., 1982. EVALUATION OF THE RADIOIMMUNOASSAY (RIA) FOR DETECTION OF CIGUATOXIN (CTX) IN FISH-TISSUES. J. Fish Biol. 21, 671-680.

Kimura, L.H., Abad, M.A., Yokochi, L.A., Hokama, J., Hokama, Y., 1983. SOLID-PHASE IMMUNO-ENZYME-LINKED ASSAY (ELISA) FOR THE DIRECT DETECTION OF CIGUATOXIN (CTX) IN FISH TISSUE. Federation Proceedings 42, 625-625.

Kimura, L.H., Hokama, Y., Abad, M.A., Oyama, M., Miyahara, J.T., 1982. COMPARISON OF 3 DIFFERENT ASSAYS FOR THE ASSESSMENT OF CIGUATOXIN IN FISH-TISSUES - RADIOIMMUNOASSAY, MOUSE BIOASSAY AND INVITRO GUINEA-PIG ATRIUM ASSAY. Toxicon 20, 907-912.

Kimura, T., Miyagawa, Y., Ozawa, S., Hagiwara, M., Nakata, T., 2009. SYNTHESIS OF 2-METHYLENETETRAHYDROPYRAN-3-OL DERIVATIVE, A KEY SEGMENT FOR CONVERGENT SYNTHESIS OF POLYCYCLIC ETHERS BASED ON SUZUKI-MIYAURA COUPLING. Heterocycles 77, 829-835.

Kira, K., Hamajima, A., Isobe, M., 2002. Synthesis of the BCD-ring of ciguatoxin 1B using an acetylene cobalt complex and vinylsilane strategy. Tetrahedron 58, 1875-1888.

Kira, K., Isobe, M., 2000. Acetylene cobalt complex and vinylsilane strategy in the synthesis of ciguatoxin (D)EF analog. Tetrahedron Lett. 41, 5951-5955.

Kira, K., Isobe, M., 2001. Synthesis of the BCDE rings of ciguatoxin 1B via an acetylene biscobalthexacarbonyl-vinylsilane strategy. Tetrahedron Lett. 42, 2821-2824.

Kirkpatrick, B., Fleming, L.E., Squicciarini, D., Backer, L.C., Clark, R., Abraham, W., Benson, J., Cheng, Y.S., Johnson, D., Pierce, R., Zaias, J., Bossart, G.D., Baden, D.G., 2004. Literature review of Florida red tide: implications for human health effects. Harmful Algae 3, 99-115.

Kishi, Y., 1996. Complete structure of maitotoxin, 20th IUPAC Symposium on the Chemistry of Natural Products, Chicago, Illinois, pp. 339-344.

Kishi, Y., 1998. Complete structure of maitotoxin. Pure and Applied Chemistry 70, 339-344.

Kita, M., Uemura, D., 2010. Marine Huge Molecules: the Longest Carbon Chains in Natural Products. Chem. Rec. 10, 48-52.

Klapperstuck, M., Buttner, C., Bohm, T., Schmalzing, G., Markwardt, F., 2000. Characteristics of P2X(7) receptors from human B lymphocytes expressed in Xenopus oocytes. Biochim. Biophys. Acta-Biomembr. 1467, 444-456.

Klug, M., Weber, J., 1991. AN EXTRACT FROM HYDRA-VULGARIS (CNIDARIA) NEMATOCYSTS INCREASES CYTOPLASMIC CA2+ LEVELS IN FIBROBLASTS. Toxicon 29, 129-133.

Knoblach, S.M., Alroy, D.A., Nikolaeva, M., Cernak, I., Stoica, B.A., Faden, A.I., 2004. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism 24, 1119-1132.

Kobayashi, M., 1987. THE MODE OF CARDIOTOXIC AND ARRHYTHMOGENIC ACTIONS OF MAITOTOXIN IN ATRIAL MUSCLE AND CARDIAC MYOCYTES. J. Mol. Cell. Cardiol. 19, S39-S39.

Kobayashi, M., Goshima, K., Ochi, R., Ohizumi, Y., 1987. ARRHYTHMOGENIC ACTION OF MAITOTOXIN IN GUINEA-PIG AND RAT CARDIAC-MUSCLE. Eur. J. Pharmacol. 142, 1-8.

Kobayashi, M., Kondo, S., Kajiwara, A., Yasumoto, T., Ohizumi, Y., 1986. THE MECHANISM OF CARDIOTOXIC EFFECTS OF MAITOTOXIN FROM POISONOUS FISH ON CARDIAC-MUSCLE. Japanese Journal of Pharmacology 40, P235-P235.

Kobayashi, M., Kondo, S., Yasumoto, T., Ohizumi, Y., 1986. CARDIOTOXIC EFFECTS OF MAITOTOXIN, A PRINCIPAL TOXIN OF SEAFOOD POISONING, ON GUINEA-PIG AND RAT CARDIAC-MUSCLE. J. Pharmacol. Exp. Ther. 238, 1077-1083.

Kobayashi, M., Miyakoda, G., Nakamura, T., Ohizumi, Y., 1985. CA-DEPENDENT ARRHYTHMOGENIC EFFECTS OF MAITOTOXIN, THE MOST POTENT MARINE TOXIN KNOWN, ON ISOLATED RAT CARDIAC-MUSCLE CELLS. Eur. J. Pharmacol. 111, 121-123.

Kobayashi, M., Muroyama, A., Nakamura, H., Kobayashi, J., Ohizumi, Y., 1991. XESTOQUINONE, A NOVEL CARDIOTONIC AGENT ACTIVATES ACTOMYOSIN ATPASE TO ENHANCE CONTRACTILITY OF SKINNED CARDIAC OR SKELETAL-MUSCLE FIBERS. J. Pharmacol. Exp. Ther. 257, 90-94.

Kobayashi, M., Nakamura, H., Kobayashi, J., Ohizumi, Y., 1991. MECHANISM OF INOTROPIC ACTION OF XESTOQUINONE, A NOVEL CARDIOTONIC AGENT ISOLATED FROM A SEA SPONGE. J. Pharmacol. Exp. Ther. 257, 82-89.

Kobayashi, M., Ochi, R., Ohizumi, Y., 1987. MAITOTOXIN-ACTIVATED SINGLE CALCIUM CHANNELS IN GUINEA-PIG CARDIAC-CELLS. Br. J. Pharmacol. 92, 665-671.

Kobayashi, M., Ochi, R., Ohizumi, Y., 1987. WHOLE-CELL CLAMP ANALYSIS OF MAITOTOXIN-ACTIVATED CA CHANNELS IN CARDIAC MYOCYTES. Japanese Journal of Pharmacology 43, P93-P93.

Kobayashi, M., Ohizumi, Y., Miyakoda, G., Nakamura, T., Yasumoto, T., 1985. CA-DEPENDENT ARRHYTHMOGENIC EFFECTS OF MAITOTOXIN, THE MOST POTENT MARINE TOXIN KNOWN, ON THE ISOLATED RAT CARDIAC MYOCYTES. J. Mol. Cell. Cardiol. 17, 52-52.

Kobayashi, M., Ohizumi, Y., Yasumoto, T., 1984. EFFECT OF MAITOTOXIN, THE MOST POTENT MARINE TOXIN, ON THE ISOLATED GUINEA-PIG HEART. Japanese Journal of Pharmacology 36, P294-P294.

Kobayashi, M., Ohizumi, Y., Yasumoto, T., 1985. THE MECHANISM OF ACTION OF MAITOTOXIN IN RELATION TO CA-2+ MOVEMENTS IN GUINEA-PIG AND RAT CARDIAC MUSCLES. Br. J. Pharmacol. 86, 385-391.

Kobayashi, S., Alizadeh, B.H., Sasaki, S., Oguri, H., Hirama, M., 2004. Synthesis of the fully functionalized ABCDE ring moiety of ciguatoxin. Org. Lett. 6, 751-754.

Kobayashi, S., Hori, M., Hirama, M., 2008. Synthesis of trans-fused tetrahydrooxepins: stereoselective allylation of sulfur or fluoro-substituted tetrahydrooxepins. Carbohydr. Res. 343, 443-452.

Kobayashi, S., Takahashi, Y., Komano, K., Alizadeh, B.H., Kawada, Y., Oishi, T., Tanaka, S., Ogasawara, Y., Sasaki, S., Hirama, M., 2004. Stereocontrolled synthesis of the ABCDE ring moiety of ciguatoxin CTX3C. Tetrahedron 60, 8375-8396.

Kobayashi, Y., Lee, J., Tezuka, K., Kishi, Y., 1999. Toward creation of a universal NMR database for the stereochemical assignment of acyclic compounds: The case of two contiguous propionate units. Org. Lett. 1, 2177-2180.

Kobayashi, Y., Tan, C.H., Kishi, Y., 2000. Toward creation of a universal NMR database for stereochemical assignment: The case of 1,3,5-trisubstituted acyclic systems. Helvetica Chimica Acta 83, 2562-2571.

Kobayashi, Y., Tan, C.H., Kishi, Y., 2001. Toward creation of a universal NMR database for stereochemical assignment: Complete structure of the desertomycin/oasomycin class of natural products. J. Am. Chem. Soc. 123, 2076-2078.

Koch, J.P., Korbmacher, C., 2000. Mechanism of shrinkage activation of nonselective cation channels in M-1 mouse cortical collecting duct cells. J. Membr. Biol. 177, 231-242.

Kodama, A.M., Hokama, Y., Yasumoto, T., Fukui, M., Manea, S.J., Sutherland, N., 1989. CLINICAL AND LABORATORY FINDINGS IMPLICATING PALYTOXIN AS CAUSE OF CIGUATERA POISONING DUE TO DECAPTERUS-MACROSOMA (MACKEREL). Toxicon 27, 1051-1053.

Kohler, S.T., Kohler, C.C., 1992. DEAD BLEACHED CORAL PROVIDES NEW SURFACES FOR DINOFLAGELLATES IMPLICATED IN CIGUATERA FISH POISONINGS. Environmental Biology of Fishes 35, 413-416.

Koike, K., Ishimaru, T., Murano, M., 1991. DISTRIBUTIONS OF BENTHIC DINOFLAGELLATES IN AKAJIMA ISLAND, OKINAWA, JAPAN. Nippon Suisan Gakkaishi 57, 2261-2264.

Koike, K., Judd, A.M., Login, I.S., Yasumoto, T., Macleod, R.M., 1986. MAITOTOXIN, A CALCIUM-CHANNEL ACTIVATOR, INCREASES PROLACTIN-RELEASE FROM RAT PITUITARY-TUMOR 7315A-CELLS BY A MECHANISM THAT MAY INVOLVE LEUKOTRIENE PRODUCTION. Neuroendocrinology 43, 283-290.

Konoki, K., Hashimoto, M., Honda, K., Tachibana, K., Tamate, R., Hasegawa, F., Oishi, T., Murata, M., 2009. MAITOTOXIN-PHOTOACTIVE PROBE BINDS TO MEMBRANE PROTEINS IN BLOOD CELLS. Heterocycles 79, 1007-1017.

Konoki, K., Hashimoto, M., Murata, M., Tachibana, K., 1999. Maitotoxin-induced calcium influx in erythrocyte ghosts and rat glioma C6 cells, and blockade by gangliosides and other membrane lipids. Chem. Res. Toxicol. 12, 993-1001.

Konoki, K., Hashimoto, M., Murata, M., Tachibana, K., Yasumoto, T., 1996. Blockade of MTX-induced Ca2+ influx in rat glioma C6 cells by alkylamines. Journal of Natural Toxins 5, 209-217.

Konoki, K., Hashimoto, M., Nonomura, T., Sasaki, M., Murata, M., Tachibana, K., 1998. Inhibition of maitotoxin-induced Ca2+ influx in rat glioma C6 cells by brevetoxins and synthetic fragments of maitotoxin. J. Neurochem. 70, 409-416.

Koschel, K., Meissner, N.N., Tas, P.W.L., 1995. Influence of cadmium ions on endothelin-1 binding and calcium signaling in rat glioma C6 cells. Toxicol. Lett. 81, 189-195.

Kumar-Roine, S., Darius, H.T., Matsui, M., Fabre, N., Haddad, M., Chinain, M., Pauillac, S., Laurent, D., 2011. A Review of Traditional Remedies of Ciguatera Fish Poisoning in the Pacific. Phytother. Res. 25, 947-958.

Kumar-Roine, S., Matsui, M., Chinain, M., Laurent, D., Pauillac, S., 2008. Modulation of inducible nitric oxide synthase gene expression in RAW 264.7 murine macrophages by Pacific ciguatoxin. Nitric Oxide-Biol. Chem. 19, 21-28.

Kumar-Roine, S., Matsui, M., Reybier, K., Darius, H.T., Chinain, M., Pauillac, S., Laurent, D., 2009. Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages. J Ethnopharmacol 123, 369-377.

Kumar-Roiné, S., Matsui, M., Reybier, K., Darius, H.T., Chinain, M., Pauillac, S., Laurent, D., 2009. Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages. Journal of Ethnopharmacology 123, 369-377.

Kuranaga, T., Satake, M., Baden, D.G., Wright, J.L.C., Tachibana, K., 2010. Synthesis of the BC/DE ring model of brevisin for confirmation of the structure around the acyclic junction. Tetrahedron Lett. 51, 4673-4676.

Kuroda, Y., Yoshii, M., Tsunoo, A., Yasumoto, T., Narahashi, T., 1984. RECORDING OF CALCIUM CURRENT IN GIGA-OHM SEALED NEURO-BLASTOMA CELLS AND THE MECHANISM OF ACTION OF MAITOTOXIN. Neurochemical Research 9, 1172-1172.

Kutty, R.K., Singh, Y., Krishna, G., 1988. EXTRACELLULAR CALCIUM IS ESSENTIAL FOR MAITOTOXIN-INDUCED CELL-DEATH - ATP DEPLETION PRECEDES CELL KILLING. Faseb J. 2, A407-A407.

Kutty, R.K., Singh, Y., Santostasi, G., Krishna, G., 1989. MAITOTOXIN-INDUCED LIVER-CELL DEATH INVOLVING LOSS OF CELL ATP FOLLOWING INFLUX OF CALCIUM. Toxicol. Appl. Pharmacol. 101, 1-10.

Kwan, L.C., Cheung, D.K.F., Kam, K.M., 2003. Peak occurrences of ciguatera fish poisoning precede cholera outbreaks in Hong Kong. Epidemiology and Infection 131, 621-626.

Labrousse, H., Matile, L., 1996. Toxicological biotest on diptera larvae to detect ciguatoxins and various other toxic substances. Toxicon 34, 881-891.

Laczay, P., 2004. Chemical-toxicological safety of the Hungarian foods of animal origin. 3. Biological contaminants. Magyar Allatorvosok Lapja 126, 371-380.

Laigret, J., Parc, F., Chanteau, S., Ducousso, R., Lafon, M., Bagnis, R., Lechat, I., 1981. THE DIRECT RADIO-IMMUNOLOGICAL DETECTION OF CIGUATOXIN IN FISH-TISSUES - CURRENT ABSENCE OF SPECIFIC IMMUNE-SERUM. Medecine Et Armees 9, 337-339.

Lange, W.R., Snyder, F.R., Fudala, P.J., 1992. TRAVEL AND CIGUATERA FISH POISONING. Archives of Internal Medicine 152, 2049-2053.

Lartigue, J., Jester, E.L.E., Dickey, R.W., Villareal, T.A., 2009. Nitrogen source effects on the growth and toxicity of two strains of the ciguatera-causing dinoflagellate Gambierdiscus toxicus. Harmful Algae 8, 781-791.

Laser, E.D., Shenefelt, P.D., 2011. Hypnosis to Alleviate the Symptoms of Ciguatera Toxicity: A Case Study. Am. J. Clin. Hypn. 54, 179-183.

Laurent, D., 1993. CIGUATERA - AN INTOXICATION CONNECTED WITH TROPICAL FISH CONSUMPTION. Annales De La Societe Belge De Medecine Tropicale 73, 7-19.

Laurent, D., Kerbrat, A.S., Darius, H.T., Girard, E., Golubic, S., Benoit, E., Sauviat, M.P., Chinain, M., Molgo, J., Pauillac, S., 2008. Are cyanobacteria involved in Ciguatera Fish Poisoning-like outbreaks in New Caledonia? Harmful Algae 7, 827-838.

Laurent, D., Kerbrat, A.S., Darius, H.T., Rossi, F., Yeeting, B., Haddad, M., Golubic, S., Pauillac, M., Chinain, M., 2011. Ciguatera Shellfish Poisoning (CSP): A new ecotoxicological phenomenon from cyanobacteria to humans via giant clams, Food Chains: New Research, pp. 1-43.

Le Gall, F., Favreau, P., Benoit, E., Mattei, C., Bouet, F., Menou, J.L., Menez, A., Letourneux, Y., Molgo, J., 1999. A new conotoxin isolated from Conus consors venom acting selectively on axons and motor nerve terminals through a Na+ -dependent mechanism. Eur. J. Neurosci. 11, 3134-3142.

Lebrun, P., Hermann, M., Yasumoto, T., Herchuelz, A., 1987. EFFECTS OF MAITOTOXIN ON IONIC AND SECRETORY EVENTS IN RAT PANCREATIC-ISLETS. Biochem. Biophys. Res. Commun. 144, 172-177.

Ledoux, M., Fremy, J.M., 1994. PHYTOPLANKTON, PHYCOTOXINS AND SEAFOOD POISONING. Recueil De Medecine Veterinaire 170, 129-139.

Ledreux, A., Brand, H., Chinain, M., Bottein, M.-Y.D., Ramsdell, J.S., 2014. Dynamics of ciguatoxins from Gambierdiscus polynesiensis in the benthic herbivore Mugil cephalus: Trophic transfer implications. Harmful Algae 39, 165-174.

Ledreux, A., Ramsdell, J.S., 2013. Bioavailability and intravenous toxicokinetic parameters for Pacific ciguatoxin P-CTX-1 in rats. Toxicon 64, 81-86.

Ledreux, A., Serandour, A.L., Morin, B., Derick, S., Lanceleur, R., Hamlaoui, S., Furger, C., Bire, R., Krys, S., Fessard, V., Troussellier, M., Bernard, C., 2012. Collaborative study for the detection of toxic compounds in shellfish extracts using cell-based assays. Part II: application to shellfish extracts spiked with lipophilic marine toxins. Anal. Bioanal. Chem. 403, 1995-2007.

Lee, C.Y., Panicker, G., Bej, A.K., 2003. Detection of pathogenic bacteria in shellfish using multiplex PCR followed by CovaLink (TM) NH microwell plate sandwich hybridization. J. Microbiol. Methods 53, 199-209.

Lee, N., Inoue, M., Hirama, M., 2009. DESIGN AND SYNTHESIS OF A CONFORMATIONALLY RESTRICTED ANALOGUE OF THE EFGH-RING SYSTEM OF CIGUATOXIN. Heterocycles 79, 325-330.

Lee, Z.W., Kwon, S.M., Kim, S.W., Yi, S.J., Kim, Y.M., Ha, K.S., 2003. Activation of in situ tissue transglutaminase by intracellular reactive oxygen species. Biochem. Biophys. Res. Commun. 305, 633-640.

Leech, C.A., Habener, J.F., 1997. Insulinotropic glucagon-like peptide-1-mediated activation of non-selective cation currents in insulinoma cells is mimicked by maitotoxin. J. Biol. Chem. 272, 17987-17993.

Leech, C.A., Habener, J.F., 1998. A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells. Diabetes 47, 1066-1073.

Leeuwenburgh, M.A., Kulker, C., Overkleeft, H.S., van der Marel, G.A., van Boom, J.H., 1999. Synthesis of a trans-fused tricyclic ether using a novel differentially protected glucal. Synlett, 1945-1947.

Legrand, A.M., 1991. Les toxines de la ciguatera, in: Fremy, J.M. (Ed.), Actes du Colloque sur les Biotoxines Marines. Centre National d'Etudes Veterinaires et Alimentaires, pp. 53-60.

Legrand, A.M., Bagnis, R., 1984. EFFECTS OF CIGUATOXIN AND MAITOTOXIN ON ISOLATED RAT ATRIA AND RABBIT DUODENUM. Toxicon 22, 471-475.

Legrand, A.M., Fukui, M., Cruchet, P., Yasumoto, T., 1992. Progress on chemical knowledge of ciguatoxins. Bull. Soc. Pathol. Exot. 85, 467-469.

Legrand, A.M., Litaudon, M., Genthon, J.N., Bagnis, R., Yasumoto, T., 1989. Isolation and some properties of ciguatoxin. Journal of Applied Phycology [J. Appl. Phycol.] 1, 183-188.

Legrand, A.-M., Teai, T., Cruchet, P., Satake, M., Murata, K., Yasumoto, T., 1998. Two structural types of ciguatoxin involved in ciguatera fish poisoning in French Polynesia, in: Reguera, B., Blanco, J., Fernandez, M.L., Wyatt, T. (Eds.), Harmful Algae. Xunta de Galicia and Intergovernmental Oceanographic Commission of UNESCO, pp. 473-475.

Lehane, L., 2000. Ciguatera update. Medical Journal of Australia 172, 176-179.

Lehane, L., Lewis, R.J., 2000. Ciguatera: recent advances but the risk remains. Int. J. Food Microbiol. 61, 91-125.

Lei, I.F., Roffey, P., Blanchard, C., Gu, K., 2008. Development of a multiplex PCR method for the detection of six common foodborne pathogens. J. Food Drug Anal. 16, 37-43.

Lei, J., Zhou, J.J., 2002. A marine natural product database. J. Chem. Inf. Comput. Sci. 42, 742-748.

Lenoir, S., Ten-Hage, L., Turquet, J., Quod, J.P., Hennion, M.C., 2004. Characterisation of new analogues of palytoxin isolated from an Ostreopsis mascarenensis bloom in the south-western Indian Ocean, 11th International Conference on Harmful Algae. Natl Inquiry Services Centre Pty Ltd, Cape Town, SOUTH AFRICA, pp. 389-391.

LePage, K.T., Rainier, J.D., Johnson, H.W.B., Baden, D.G., Murray, T.F., 2007. Gambierol acts as a functional antagonist of neurotoxin site 5 on voltage-gated sodium channels in cerebellar granule neurons. J. Pharmacol. Exp. Ther. 323, 174-179.

Lesort, M., Attanavanich, K., Zhang, J.W., Johnson, G.V.W., 1998. Distinct nuclear localization and activity of tissue transglutaminase. J. Biol. Chem. 273, 11991-11994.

Lewandowski, G., Rytwinska, E., 2006. Reactions and applications of trans-1, 2-epoxy(Z,E)-cyclododeca-5,9-diene. Chem. Pap.-Chem. Zvesti 60, 160-168.

Lewis, N.D., 1984. Ciguatera in the Pacific: Incidence and implications for marine resource development, in: Ragelis, E.P. (Ed.), Seafood Toxins. Am. Chem. Soc. Symp. Ser. No. 262, Washington, DC., pp. 289-306.

Lewis, R.J., 1985. INTERACTIONS BETWEEN CIGUATOXIN AND LOCAL-ANESTHETICS ON THE GUINEA-PIG LEFT ATRIA. Toxicon 23, 588-588.

Lewis, R.J., 1988. NEGATIVE INOTROPIC AND ARRHYTHMIC EFFECTS OF HIGH-DOSES OF CIGUATOXIN ON GUINEA-PIG ATRIA AND PAPILLARY-MUSCLES. Toxicon 26, 639-649.

Lewis, R.J., 1992. CIGUATOXINS ARE POTENT ICHTHYOTOXINS. Toxicon 30, 207-211.

Lewis, R.J., 1995. Detection of ciguatoxins and related benthic dinoflagellate toxins: in vivo and in vitro methods, in: Hallegraeff, G.M., Anderson, D.M., Cembella, A.D. (Eds.), Manual on harmful marine microalgae. Intergovernmental Oceanographic Commission of UNESCO, Paris, pp. 135-162.

Lewis, R.J., 2000. Ion channel toxins and therapeutics: From cone snail venoms to ciguatera. Therapeutic Drug Monitoring 22, 61-64.

Lewis, R.J., 2001. The changing face of ciguatera. Toxicon 39, 97-106.

Lewis, R.J., 2002. Ciguatera: Australian perspectives on a global problem, 6th Asia/Pacific Congress on Animals, Plant and Microbial Toxins/11th Annual Scientific Meeting of the Australiasian-College-of-Tropical-Medicine. Pergamon-Elsevier Science Ltd, Cairns, AUSTRALIA, pp. 799-809.

Lewis, R.J., 2006. Ciguatera: Australian perspectives on a global problem. Toxicon 48, 799-809.

Lewis, R.J., Endean, R., 1983. OCCURRENCE OF A CIGUATOXIN-LIKE SUBSTANCE IN THE SPANISH MACKEREL (SCOMBEROMORUS-COMMERSONI). Toxicon 21, 19-24.

Lewis, R.J., Endean, R., 1984. CIGUATOXIN FROM THE FLESH AND VISCERA OF THE BARRACUDA, SPHYRAENA-JELLO. Toxicon 22, 805-810.

Lewis, R.J., Endean, R., 1984. MODE OF ACTION OF CIGUATOXIN FROM THE SPANISH MACKEREL, SCOMBEROMORUS-COMMERSONI, ON THE GUINEA-PIG ILEUM AND VASDEFERENS. J. Pharmacol. Exp. Ther. 228, 756-760.

Lewis, R.J., Endean, R., 1986. DIRECT AND INDIRECT EFFECTS OF CIGUATOXIN ON GUINEA-PIG ATRIA AND PAPILLARY-MUSCLES. Naunyn-Schmiedebergs Arch. Pharmacol. 334, 313-322.

Lewis, R.J., Holmes, M.J., 1993. ORIGIN AND TRANSFER OF TOXINS INVOLVED IN CIGUATERA. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology 106, 615-628.

Lewis, R.J., Holmes, M.J., Alewood, P.F., Jones, A., 1994. Ionspray mass spectrometry of ciguatoxin-1, maitotoxin-2 and -3, and related marine polyether toxins. Nat. Toxins 2, 56-63.

Lewis, R.J., Hoy, A.W.W., 1993. COMPARATIVE ACTION OF 3 MAJOR CIGUATOXINS ON GUINEA-PIG ATRIA AND ILEA. Toxicon 31, 437-446.

Lewis, R.J., Hoy, A.W.W., McGiffin, D.C., 1992. ACTION OF CIGUATOXIN ON HUMAN ATRIAL TRABECULAE. Toxicon 30, 907-914.

Lewis, R.J., Hoy, A.W.W., Sellin, M., 1993. Ciguatera and mannitol: in vivo and in vitro assessment in mice. Toxicon [Toxicon] 31, 1039-1050.

Lewis, R.J., Inserra, M., Vetter, I., Holland, W.C., Hardison, D.R., Tester, P.A., Litaker, R.W., 2016. Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional Bioassay. PLoS One 11, e0160006.

Lewis, R.J., Jones, A., 1997. Characterization of ciguatoxins and ciguatoxin congeners present in ciguateric fish by gradient reverse-phase high-performance liquid chromatography/mass spectrometry. Toxicon 35, 159-168.

Lewis, R.J., Jones, A., Vernoux, J.P., 1997. HPLC/mass spectrometry and HPLC/MS/MS methods for the detection of multiple ciguatoxins, in: Seret, B., Sire, J.Y. (Eds.), 5th Indo-Pacific Fish Conference, Noumea, New Caledonia, pp. 739-744.

Lewis, R.J., Jones, A., Vernoux, J.P., 1999. HPLC/tandem electrospray mass spectrometry for the determination of sub-ppb levels of Pacific and Caribbean ciguatoxins in crude extracts of fish. Anal. Chem. 71, 247-250.

Lewis, R.J., Jones, A., Vernoux, J.-P., Marquais, M., 1998. Sensitive detection of multiple ciguatoxins by HPLC/MS/MS, in: Reguera, B., Blanco, J., Fernandez, M.L., Wyatt, T. (Eds.), Harmful Algae. Xunta de Galicia and Intergovernmental Oceanographic Commission of UNESCO, pp. 523-524.

Lewis, R.J., Norton, R.S., Brereton, I.M., Eccles, C.D., 1993. CIGUATOXIN-2 IS A DIASTEREOMER OF CIGUATOXIN-3. Toxicon 31, 637-643.

Lewis, R.J., Ruff, T.A., 1993. CIGUATERA - ECOLOGICAL, CLINICAL, AND SOCIOECONOMIC PERSPECTIVES. Critical Reviews in Environmental Science and Technology 23, 137-156.

Lewis, R.J., Sellin, M., 1992. Multiple ciguatoxins in the flesh of fish. Toxicon 30, 915-919.

Lewis, R.J., Sellin, M., 1993. RECOVERY OF CIGUATOXIN FROM FISH FLESH. Toxicon 31, 1333-1336.

Lewis, R.J., Sellin, M., Poli, M.A., Norton, R.S., Macleod, J.K., Sheil, M.M., 1991. PURIFICATION AND CHARACTERIZATION OF CIGUATOXINS FROM MORAY EEL (LYCODONTIS-JAVANICUS, MURAENIDAE). Toxicon 29, 1115-1127.

Lewis, R.J., Vernoux, J.P., Brereton, I.M., 1998. Structure of Caribbean ciguatoxin isolated from Caranx latus. J. Am. Chem. Soc. 120, 5914-5920.

Lewis, R.J., Vetter, I., 2015. Ciguatoxin and Ciguatera, in: Gopalakrishnakone, P., Haddad Jr, V., Kem, R.W., Tubaro, A., Kim, E. (Eds.), Marine and Freshwater Toxins: Marine and Freshwater Toxins. Springer Netherlands, Dordrecht, pp. 1-19.

Lewis, R.J., Yang, A., Jones, A., 2009. Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins in ciguateric fish flesh. Toxicon 54, 62-66.

Lewis, R.J., Yang, A.J., Jones, A., 2009. Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins in ciguateric fish flesh. Toxicon 54, 62-66.

Li, R.A., Tsushima, R.G., Kallen, R.G., Backx, P.H., 1997. Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis. Biophys. J. 73, 1874-1884.

Lin, W.W., Lee, C.Y., Chuang, D.M., 1991. ENDOTHELIN-INDUCED AND SARAFOTOXIN-INDUCED PHOSPHOINOSITIDE HYDROLYSIS IN CULTURED CEREBELLAR GRANULE CELLS - BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION. J. Pharmacol. Exp. Ther. 257, 1053-1061.

Lin, W.W., Lee, C.Y., Yasumoto, T., 1989. CONTRACTURE AND TWITCH DEPRESSION INDUCED BY MAITOTOXIN IN SKELETAL-MUSCLE. Asia Pacific Journal of Pharmacology 4, 9-15.

Lin, W.W., Lee, C.Y., Yasumoto, T., Chuang, D.M., 1990. MAITOTOXIN INDUCES PHOSPHOINOSITIDE TURNOVER AND MODULATES GLUTAMATERGIC AND MUSCARINIC CHOLINERGIC RECEPTOR FUNCTION IN CULTURED CEREBELLAR NEURONS. J. Neurochem. 55, 1563-1568.

Lipp, E.K., Rose, J.B., 1997. The role of seafood in foodborne diseases in the United States of America. Revue Scientifique Et Technique De L Office International Des Epizooties 16, 620-640.

Litaker, R.W., Vandersea, M.W., Faust, M.A., Kibler, S.R., Chinain, M., Holmes, M.J., Holland, W.C., Tester, P.A., 2009. Taxonomy of Gambierdiscus including four new species, Gambierdiscus caribaeus, Gambierdiscus carolinianus, Gambierdiscus carpenteri and Gambierdiscus ruetzleri (Gonyaulacales, Dinophyceae). Phycologia 48, 344-390.

Litaker, R.W., Vandersea, M.W., Faust, M.A., Kibler, S.R., Nau, A.W., Holland, W.C., Chinain, M., Holmes, M.J., Tester, P.A., 2010. Global distribution of ciguatera causing dinoflagellates in the genus Gambierdiscus. Toxicon 56, 711-730.

Liu, H.H., Liu, G.H., Yang, J., Chen, Y.H., Zhu, Z., 2009. High Performance Liquid Chromatography Coupled with Electrospray Tandem Mass Spectrometry for Analysis of Pacific Ciguatoxin in Fishes. Chin. J. Anal. Chem. 37, 1675-1678.

Liu, T.Z., Isobe, M., 2000. Synthesis of the H-I-J tricyclic fragment of ciguatoxin, a marine polyether toxin. Synlett, 266-268.

Liu, T.Z., Isobe, M., 2000. Synthetic studies on the HIJK-ring fragment of ciguatoxin. Tetrahedron 56, 5391-5404.

Liu, T.Z., Kirschbaum, B., Isobe, M., 2000. Heteroconjugate addition strategy for the synthesis of the (HIJ)K-ring fragment of ciguatoxin. Synlett, 587-590.

Liu, T.Z., Li, J.M., Isobe, M., 2000. Synthetic studies on ciguatoxin - Synthesis of H-I-J ring system. Tetrahedron 56, 10209-10219.

Llewellyn, L.E., 2010. Revisiting the association between sea surface temperature and the epidemiology of fish poisoning in the South Pacific: Reassessing the link between ciguatera and climate change. Toxicon 56, 691-697.

Lobel, P.S., Anderson, D.M., Durand-Clement, M., 1988. Assessment of ciguatera dinoflagellate populations: Sample variability and algal substrate selection. Biological Bulletin [Biol. Bull.] 175, 94-101.

Login, I.S., Judd, A.M., Cronin, M.J., Koike, K., Schettini, G., Yasumoto, T., Macleod, R.M., 1985. THE EFFECTS OF MAITOTOXIN ON CA-45(2+) FLUX AND HORMONE-RELEASE IN GH3 RAT PITUITARY-CELLS. Endocrinology 116, 622-627.

Login, I.S., Judd, A.M., Macleod, R.M., 1986. DOPAMINE INHIBITS MAITOTOXIN-STIMULATED PITUITARY CA-45(2+) EFFLUX AND PROLACTIN-RELEASE. American Journal of Physiology 250, E731-E735.

Login, I.S., Judd, A.M., Macleod, R.M., 1987. ACTIVATION OF CALCIUM CHANNELS BY MAITOTOXIN. Methods in Enzymology 141, 63-79.

Lombet, A., Bidard, J.N., Lazdunski, M., 1987. CIGUATOXIN AND BREVETOXINS SHARE A COMMON RECEPTOR-SITE ON THE NEURONAL VOLTAGE-DEPENDENT NA-(+) CHANNEL. FEBS Lett. 219, 355-359.

Lombet, A., Bidard, J.-N., Lazdunski, M., 1987. Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage-dependent Na+ channel. FEBS Letters [FEBS Lett.] 219, 355-359.

Louzao, M.C., Ares, I.R., Vieytes, M.R., Yasumoto, T., Botana, L.M., 2005. Cytotoxic responses induced by maitotoxin in human neuroblastoma cells. Biophys. J. 88, 494A-494A.

Louzao, M.C., Cagide, E., Vieytes, M.R., Sasaki, M., Fuwa, H., Yasumoto, T., Botana, L.M., 2006. The sodium channel of human excitable cells is a target for gambierol. Cell. Physiol. Biochem. 17, 257-268.

Louzao, M.C., Vieytes, M.R., Yasumoto, T., Botana, L.M., 2004. Detection of sodium channel activators by a rapid fluorimetric microplate assay. Chem. Res. Toxicol. 17, 572-578.

Louzao, M.d.C., Vieytes, M.R., Yasumoto, T., Yotsu-Yamashita, M., Botana, L.M., 2006. Changes in membrane potential: An early signal triggered by neurologically active phycotoxins. Chem. Res. Toxicol. 19, 788-793.

Lu, X.G., Wang, L., Bhattacharjee, A., Li, M., 1997. Investigation of the cellular toxic mechanisms of Caribbean maitotoxin. Biophys. J. 72, WP111-WP111.

Lucas, R.E., Lewis, R.J., Taylor, J.M., 1997. Pacific ciguatoxin-1 associated with a large common-source outbreak of ciguatera in East Arnhem Land, Australia. Nat. Toxins 5, 136-140.

Luckas, B., 2000. Phycotoxins in the marine environment: control of marine organisms for contamination with algal toxins. International Journal of Environment and Pollution 13, 148-172.

Lundy, P.M., Nelson, P., Mi, L., Frew, R., Minaker, S., Vair, C., Sawyer, T.W., 2004. Pharmacological differentiation of the P2X(7) receptor and the maitotoxin-activated cationic channel. Eur. J. Pharmacol. 487, 17-28.

Luo, H.-d., Bai, Y.-y., Zhou, N., 2011. Study of three ciguatera fish poisoning cases in Xiamen city, in 2005. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 45, 512-515.

Luo, S., Zhangsun, D.T., Zhang, B., Quan, Y., Wu, Y., 2006. Novel alpha-conotoxins identified by gene sequencing from cone snails native to Hainan, and their sequence diversity. J. Pept. Sci. 12, 693-704.

Lv, J., Zhong, X.R., Cheng, J.P., Luo, S.Z., 2012. Asymmetric Binary-Acid Catalysis in the Inverse-Electron-Demanding Hetero-Diels-Alder Reaction of 3,4-Dihydro-2H-Pyran. Acta Chimica Sinica 70, 1518-1522.

M., H.J., 1994. Seafood toxins. Journal of AOAC International. 77, 145-149.

M.M., W., 1990. Seafood toxins. JAOAC International 73, 113-116.

Ma, H.Y., Krock, B., Tillmann, U., Bickmeyer, U., Graeve, M., Cembella, A., 2011. Mode of action of membrane-disruptive lytic compounds from the marine dinoflagellate Alexandrium tamarense. Toxicon 58, 247-258.

Maeda, K., Oishi, T., Oguri, H., Hirama, M., 1999. Convergent synthesis of the ABCDE ring framework of ciguatoxin. Chem. Commun., 1063-1064.

Maemoto, M., Kimishima, A., Nakata, T., 2009. Stereoselective Synthesis of 2,6-syn-Dimethyl-tetrahydropyran Derivatives, Important Segments of Marine Polycyclic Ethers, by Unique Insertion of the Methyl Group. Org. Lett. 11, 4814-4817.

Magnelia, S.J., Kohler, C.C., Tindall, D.R., 1992. ACANTHURIDS DO NOT AVOID CONSUMING CULTURED TOXIC DINOFLAGELLATES YET DO NOT BECOME CIGUATOXIC. Trans. Am. Fish. Soc. 121, 737-745.

Majhi, T.P., Neogi, A., Ghosh, S., Mukherjee, A.K., Chattopadhyay, P., 2006. Sequential Baylis-Hillman reaction and radical cyclization of furanose derivatives: expeditious approach to enantiopure benzo-fused nine-membered oxacycles. Tetrahedron 62, 12003-12010.

Mak, C.K.M., Yeung, P.K.K., Kwok, A.C.M., Wong, Y.H., Wong, J.T.Y., 2009. Multiplex fluorimetric assays for monitoring algal toxins. Journal of the Marine Biological Association of the United Kingdom 89, 287-293.

Mak, Y.L., Wai, T.-C., Murphy, M.B., Chan, W.H., Wu, J.J., Lam, J.C.W., Chan, L.L., Lam, P.K.S., 2013. Pacific Ciguatoxins in Food Web Components of Coral Reef Systems in the Republic of Kiribati. Environ. Sci. Technol. 47, 14070-14079.

Mak, Y.L., Wu, J.J., Chan, W.H., Murphy, M.B., Lam, J.C., Chan, L.L., Lam, P.K., 2013. Simultaneous quantification of Pacific ciguatoxins in fish blood using liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem 405, 3331-3340.

Mak, Y.L., Wu, J.J., Chan, W.H., Murphy, M.B., Lam, J.C.W., Chan, L.L., Lam, P.K.S., 2013. Simultaneous quantification of Pacific ciguatoxins in fish blood using liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 405, 3331-3340.

Malaguti, C., Yasumoto, T., Rossini, G.P., 1999. Transient Ca2+-dependent activation of ERK1 and ERK2 in cytotoxic responses induced by maitotoxin in breast cancer cells. FEBS Lett. 458, 137-140.

Manger, R., Woodle, D., Berger, A., Dickey, R.W., Jester, E., Takeshi, Y., Lewis, R., Hawryluk, T., Hungerford, J., 2014. Flow Cytometric-Membrane Potential Detection of Sodium Channel Active Marine Toxins: Application to Ciguatoxins in Fish Muscle and Feasibility of Automating Saxitoxin Detection. J. AOAC Int. 97, 299-306.

Manger, R., Woodle, D., Berger, A., Dickey, R.W., Jester, E., Yasumoto, T., Lewis, R., Hawryluk, T., Hungerford, J., 2014. Flow cytometric-membrane potential detection of sodium channel active marine toxins: application to ciguatoxins in fish muscle and feasibility of automating saxitoxin detection. J. AOAC Int. 97, 299-306.

Manger, R.L., Lee, S.Y., Leja, L.S., Hungerford, J.M., Hokama, Y., Dickey, R.W., Granade, H.R., Lewis, R.J., Yasumoto, T., Wekell, M.M., 1994

1995. Analysis of ciguatoxins, brevetoxins, saxitoxins and seafood extracts by cell bioassay, in: Eklund, M., Richard, J.L., Mise, K. (Eds.), Molecular Approaches to Food Safety: Issues Involving Toxic Microorganisms [8th UJNR Int. Symp.]. Alaken, pp. 123-142.

Manger, R.L., Lee, S.Y., Leja, L.S., Hungerford, J.M., Hokama, Y., Dickey, R.W., Granade, H.R., Lewis, R.J., Yasumoto, T., Wekell, M.M., 1994

1995. In vitro analysis of ciguatoxins, brevetoxins and saxitoxins, in: Hokama, Y., Scheuer, P.J., Yasumoto, T. (Eds.), Proceedings of the International Symposium on Ciguatera and Marine Natural Products. Asian-Pacific Research Foundation, Honolulu, Hawaii, pp. 123-136.

Manger, R.L., Leja, L.S., Lee, S.Y., Hungerford, J.M., Hokama, Y., Dickey, R.W., Granade, H.R., Lewis, R., Yasumoto, T., Wekell, M.M., 1993. DETECTION OF SODIUM-CHANNEL TOXINS - DIRECTED CYTOTOXICITY ASSAYS OF PURIFIED CIGUATOXINS, BREVETOXINS, SAXITOXINS, AND SEAFOOD EXTRACTS, Symposium on Analytical Methods for Seafood Toxins, at the 107th AOAC International Annual Meeting, Washington, Dc, pp. 521-527.

Manger, R.L., Leja, L.S., Lee, S.Y., Hungerford, J.M., Hokama, Y., Dickey, R.W., Granade, H.R., Lewis, R., Yasumoto, T., Wekell, M.M., 1995. DETECTION OF SODIUM-CHANNEL TOXINS - DIRECTED CYTOTOXICITY ASSAYS OF PURIFIED CIGUATOXINS, BREVETOXINS, SAXITOXINS, AND SEAFOOD EXTRACTS. J. AOAC Int. 78, 521-527.

Manger, R.L., Leja, L.S., Lee, S.Y., Hungerford, J.M., Kirkpatrick, M.A., Yasumoto, T., Wekell, M.M., 2003. Detection of paralytic shellfish poison by rapid cell bioassay: Antagonism of voltage-gated sodium channel active toxins in vitro. J. AOAC Int. 86, 540-543.

Manger, R.L., Leja, L.S., Lee, S.Y., Hungerford, J.M., Wekell, M.M., 1993. Tetrazolium-based cell bioassay for neurotoxins active on voltage-sensitive sodium channels: Semiautomated assay for saxitoxins, brevetoxins, and ciguatoxins. Anal. Biochem. 214, 190-194.

Manger, R.L., Leja, L.S., Lee, S.Y., Hungerford, J.M., Wekell, M.M., 1993. TETRAZOLIUM-BASED CELL BIOASSAY FOR NEUROTOXINS ACTIVE ON VOLTAGE-SENSITIVE SODIUM-CHANNELS - SEMIAUTOMATED ASSAY FOR SAXITOXINS, BREVETOXINS, AND CIGUATOXINS. Anal. Biochem. 214, 190-194.

Manoharan, K., Negron, M., 1994

1995. Human hepatocytes in ciguatoxicity testing methods, in: Hokama, Y., Scheuer, P.J., Yasumoto, T. (Eds.), Proceedings of the International Symposium on Ciguatera and Marine Natural Products. Asian-Pacific Research Foundation, Honolulu, Hawaii, pp. 167-180.

Mariathasan, S., Weiss, D.S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W.P., Weinrauch, Y., Monack, D.M., Dixit, V.M., 2006. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440, 228-232.

Mariussen, E., Nelson, G.N., Fonnum, F., 2005. A toxic extract of the marine phytoflagellate Prymnesium parvum induces calcium-dependent release of glutamate from rat brain synaptosomes. J. Toxicol. Env. Health Part A 68, 67-79.

Marquais, M., Vernoux, J.-P., Molgó, J., Sauviat, M.-P., Lewis, R.J., 1998. Isolation and electrophysiological characterization of a new ciguatoxin extracted from Caribbean fish, in: Reguera, B., Blanco, J., Fernandez, M.L., Wyatt, T. (Eds.), Harmful Algae. Xunta de Galicia and Intergovernmental Oceanographic Commission of UNESCO, pp. 476-477.

Martin, V., Vale, C., Antelo, A., Hirama, M., Yamashita, S., Vieytes, M.R., Botana, L.M., 2014. Differential Effects of Ciguatoxin and Maitotoxin in Primary Cultures of Cortical Neurons. Chem. Res. Toxicol. 27, 1387-1400.

Martin, V., Vale, C., Hirama, M., Yamashita, S., Rubiolo, J.A., Vieytes, M.R., Botana, L.M., 2015. Synthetic Ciguatoxin CTX 3C Induces a Rapid Imbalance in Neuronal Excitability. Chem Res Toxicol.

Martin, V., Vale, C., Rubiolo, J.A., Roel, M., Hirama, M., Yamashita, S., Vieytes, M.R., Botana, L.M., 2015. Chronic Ciguatoxin Treatment Induces Synaptic Scaling through Voltage Gated Sodium Channels in Cortical Neurons. Chem Res Toxicol.

Martinez, M., Egido, W., Castrejon, V., 2007. Are the effects of maitotoxin mediated by a pore forming mechanism? Biophys. J., 613A-613A.

Martinez, M., Salvador, C., Farias, J.M., Vaca, L., Escobar, L.I., 1999. Modulation of a calcium-activated chloride current by Maitotoxin. Toxicon 37, 359-370.

Martinez-Francois, J.R., Morales, V., Vaca, L., 2000. Characterization of the maitotoxin-induced current in human skin fibroblasts. Biophys. J. 78, 173A-173A.

Martinez-Francois, J.R., Morales-Tlalpan, V., Vaca, L., 2002. Characterization of the maitotoxin-activated cationic current from human skin fibroblasts. J. Physiol.-London 538, 79-86.

Maruyama, M., Inoue, M., Oishi, T., Oguri, H., Ogasawara, Y., Shindo, Y., Hirama, M., 2002. Convergent synthesis of the ABCDE ring system of ciguatoxin CTX3C. Tetrahedron 58, 1835-1851.

Maruyama, M., Maeda, K., Oishi, T., Oguri, H., Hirama, M., 2001. Convergent strategy for synthesizing polycyclic ether marine toxins: Synthesis of the ABCDE ring fragment of ciguatoxin CTX3C. Heterocycles 54, 93-99.

Masutani, T., Taguchi, K., Kumanogoh, H., Nakamura, S., Maekawa, S., 2008. Molecular interaction of neurocalcin alpha with alsin (ALS2). Neurosci. Lett. 438, 26-28.

Matsui, M., Kumar-Roine, S., Darius, H.T., Chinain, M., Laurent, D., Pauillac, S., 2009. Characterisation of the anti-inflammatory potential of Vitex trifolia L. (Labiatae), a multipurpose plant of the Pacific traditional medicine. Journal of Ethnopharmacology 126, 427-433.

Matsui, M., Kumar-Roine, S., Darius, H.T., Chinain, M., Laurent, D., Pauillac, S., 2010. Pacific ciguatoxin 1B-induced modulation of inflammatory mediators in a murine macrophage cell line. Toxicon 56, 776-784.

Matsumori, N., Nonomura, T., Sasaki, M., Murata, M., Tachibana, K., Satake, M., Yasumoto, T., 1996. Long-range carbon-proton coupling constants for stereochemical assignment of acyclic structures in natural products: Configuration of the C5-C9 portion of maitotoxin. Tetrahedron Lett. 37, 1269-1272.

Matta, J., Milad, M., 1998. Maitotoxin-1 induces liver and plasma lipid peroxidation in CF-1 mice. Free Radic. Biol. Med. 25, S75-S75.

Matta, J., Milad, M., Manger, R., Tosteson, T., 1999. Heavy metals, lipid peroxidation, and ciguatera toxicity in the liver of the caribbean barracuda (Sphyraena barracuda). Biol. Trace Elem. Res. 70, 69-79.

Matta, J., Navas, J., Milad, M., Manger, R., Hupka, A., Frazer, T., 2002. A pilot study for the detection of acute ciguatera intoxication in human blood. Journal of Toxicology-Clinical Toxicology 40, 49-57.

Mattei, C., Benoit, E., Juzans, P., Legrand, A.M., Molgo, J., 1997. Gambiertoxin (CTX-4B), purified from wild Gambierdiscus toxicus dinoflagellates, induces Na+-dependent swelling of single frog myelinated axons and motor nerve terminals in situ. Neurosci. Lett. 234, 75-78.

Mattei, C., Dechraoui, M.Y., Molgo, J., Meunier, F.A., Legrand, A.M., Benoit, E., 1999. Neurotoxins targetting receptor site 5 of voltage-dependent sodium channels increase the nodal volume of myelinated axons. J. Neurosci. Res. 55, 666-673.

Mattei, C., Marquais, M., Schlumberger, S., Molgo, J., Vernoux, J.-P., Lewis, R.J., Benoit, E., 2010. Analysis of Caribbean ciguatoxin-1 effects on frog myelinated axons and the neuromuscular junction. Toxicon 56, 759-767.

Mattei, C., Marquais, M., Schlumberger, S., Molgó, J., Vernoux, J.-P., Lewis, R.J., Benoit, E., 2010. Analysis of Caribbean ciguatoxin-1 effects on frog myelinated axons and the neuromuscular junction. Toxicon 56, 759-767.

Mattei, C., Molgo, J., Benoit, E., 2014. Involvement of both sodium influx and potassium efflux in ciguatoxin-induced nodal swelling of frog myelinated axons. Neuropharmacology 85, 417-426.

Mattei, C., Molgo, J., Marquais, M., Vernoux, J.P., Benoit, E., 1999. Hyperosmolar D-mannitol reverses the increased membrane excitability and the nodal swelling caused by Caribbean ciguatoxin-1 in single frog myelinated axons. Brain Res. 847, 50-58.

Mattei, C., Vetter, I., Eisenblätter, A., Krock, B., Ebbecke, M., Desel, H., Zimmermann, K., 2014. Ciguatera fish poisoning: A first epidemic in Germany highlights an increasing risk for European countries. Toxicon 91, 76-83.

Mattei, C., Wen, P.J., Nguyen-Huu, T.D., Alvarez, M., Benoit, E., Bourdelais, A.J., Lewis, R.J., Baden, D.G., Molgo, J., Meunier, F.A., 2008. Brevenal Inhibits Pacific Ciguatoxin-1B-Induced Neurosecretion from Bovine Chromaffin Cells. PLoS One 3, 9.

Matus, M.H., Escobar, L., Galvan, M., 2008. Folded Conformations of Maitotoxin. J. Mex. Chem. Soc. 52, 74-77.

Matus, M.H., Garza, J., Galvan, M., 2006. Effect of double bonds on the conducting properties of ciguatoxin 3C and tetrahydropyrane-based polymers: A theoretical study. J. Phys. Chem. B 110, 1172-1178.

McCall, J.R., Jacocks, H.M., Niven, S.C., Poli, M.A., Baden, D.G., Bourdelais, A.J., 2014. Development and utilization of a fluorescence-based receptor-binding assay for the site 5 voltage-sensitive sodium channel ligands brevetoxin and ciguatoxin. J AOAC Int 97, 307-315.

McFarren, E.F., Tanabe, H., Silva, F.J., Wilson, W.B., Campbell, J.E., Lewis, K.H., 1965. The occurrence of a ciguatera-like poison in oysters, clams, and Gymnodinium breve cultures. Toxicon 3, 111-123.

McGinnis, K.M., Gnegy, M.E., Falk, N., Nath, R., Wang, K.K.W., 2003. Cytochrome c translocation does not lead to caspase activation in maitotoxin-treated SH-SY5Y neuroblastoma cells. Neurochem. Int. 42, 517-523.

McGinnis, K.M., Gnegy, M.E., Park, Y.H., Mukerjee, N., Wang, K.K.W., 1999. Procaspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates. Biochem. Biophys. Res. Commun. 263, 94-99.

McMillan, J.P., Hoffman, P.A., Granade, H.R., 1986. GAMBIERDISCUS-TOXICUS FROM THE CARIBBEAN - A SOURCE OF TOXINS INVOLVED IN CIGUATERA. Marine Fisheries Review 48, 48-52.

McPherson, C., 1998. Ciguatoxin and tetrodotoxin poisonings in the cat: Their diagnosis, treatment and management. Australian Veterinary Practitioner 28, 26-+.

Meinesz, A., Hesse, B., 1991. INTRODUCTION OF THE TROPICAL ALGA CAULERPA-TAXIFOLIA AND ITS INVASION OF THE NORTHWESTERN MEDITERRANEAN. Oceanologica Acta 14, 415-426.

Melo, A.C., Moeller, P.D.R., Glasgow, H., Burkholder, J.M., Ramsdell, J.S., 2001. Microfluorimetric analysis of a purinergic receptor (P2X(7)) in GH(4)C(1) rat pituitary cells: Effects of a bioactive substance produced by Pfiesteria piscicida. Environ. Health Perspect. 109, 731-737.

Mendoza, C.O., Rabanes, A.C., Jimenez, E.C., Azanza, R.V., Cortez-Akhunzadah, J., Cruz, L.J., 2013. Detection of ciguatera fish poisoning in the Philippines. Journal of Environmental Science and Management, 50-55.

Meucci, O., Grimaldi, M., Scorziello, A., Govoni, S., Bergamaschi, S., Yasumoto, T., Schettini, G., 1992. MAITOTOXIN-INDUCED INTRACELLULAR CALCIUM RISE IN PC12 CELLS - INVOLVEMENT OF DIHYDROPYRIDINE-SENSITIVE AND OMEGA-CONOTOXIN-SENSITIVE CALCIUM CHANNELS AND PHOSPHOINOSITIDE BREAKDOWN. J. Neurochem. 59, 679-688.

Meucci, O., Grimaldi, M., Scorziello, A., Ventra, C., Marino, A., Schettini, G., 1990. VOLTAGE-ACTIVATED CALCIUM CHANNELS IN PC12-CELLS - EFFECT OF MAITOTOXIN AND OMEGA-CONOTOXIN. Eur. J. Pharmacol. 183, 258-258.

Meyer, E.G., 1999. Ciguatera fish poisoning. Canadian Medical Association Journal 160, 1127.

Meyer, L., Capper, A., Carter, S., Simpfendorfer, C., 2016. An investigation into ciguatoxin bioaccumulation in sharks. Toxicon : official journal of the International Society on Toxinology 119, 234-243.

Meyer, L., Carter, S., Capper, A., 2015. An updated ciguatoxin extraction method and silica cleanup for use with HPLC-MS/MS for the analysis of P-CTX-1, PCTX-2 and P-CTX-3. Toxicon 108, 249-256.

Michel, A.D., Thompson, K.M., Simon, J., Boyfield, I., Fonfria, E., Humphrey, P.P.A., 2006. Species and response dependent differences in the effects of MAPK inhibitors on P2X(7) receptor function. Br. J. Pharmacol. 149, 948-957.

Miller, D.M., 1991. Ciguatera Seafood Toxins. CRC Press, Boca Raton.

Miller, D.M., Davin, W.T., Tindall, D.R., 1985. EFFECTS OF MAITOTOXIN ON GUINEA-PIG ILEUM CONTRACTION PARTIALLY AMELIORATED BY CALCIUM-CHANNEL ANTAGONISTS. Toxicon 23, 34-34.

Miller, D.M., Tindall, D.R., Hassan, F., 1985. EFFECTS OF MAITOTOXIN ON GUINEA-PIG ILEUM. Federation Proceedings 44, 1642-1642.

Miyagi, K., Matsumoto, Y., Hayashi, K., Yoh, M., Yamamoto, K., Honda, T., 1994. SUCCESSFUL APPLICATION OF ENZYME-LABELED OLIGONUCLEOTIDE PROBE FOR RAPID AND ACCURATE CHOLERA DIAGNOSIS IN A CLINICAL LABORATORY. Microbiology and Immunology 38, 301-304.

Miyahara, J., Oyama, M., Kimura, L.H., Honbo, K., Abad, M.A., Furuya, N., Hokama, Y., 1981. EXAMINATION OF 3 ASSAYS FOR CIGUATOXIN (CTX) DETERMINATION - MOUSE TOXICITY, GUINEA-PIG ATRIUM AND RADIOIMMUNOASSAY (RIA). Federation Proceedings 40, 694-694.

Miyahara, J., Shiraki, K., Akau, R., Chung, R., Joyo, B., Kimura, L.H., Hokama, Y., 1980. COMPARATIVE-EXAMINATION OF THE RADIOIMMUNOASSAY (RIA) FOR DETECTION OF CIGUATOXIN IN FISH TISSUE AND THE PHARMACOLOGICAL EFFECT OF EXTRACTED CIGUATOXIN ON MAMMALIAN ATRIA. Federation Proceedings 39, 1141-1141.

Miyahara, J.T., Akau, C.K., Yasumoto, T., 1979. EFFECTS OF CIGUATOXIN AND MAITOTOXIN ON THE ISOLATED GUINEA-PIG ATRIA. Research Communications in Chemical Pathology and Pharmacology 25, 177-180.

Miyamoto, T., Ohizumi, Y., Washio, H., Yasumoto, Y., 1984. POTENT EXCITATORY EFFECT OF MAITOTOXIN ON CA CHANNELS IN THE INSECT SKELETAL-MUSCLE. Pflugers Arch. 400, 439-441.

Mizukami, M., Saito, H., Higuchi, T., Imai, M., Bando, H., Kawahara, N., Nagumo, S., 2007. Facile synthesis of medium-sized cyclic amines based on Friedel-Crafts reaction via iminium cation by use of acetylene dicobalt complex. Tetrahedron Lett. 48, 7228-7231.

Mohammad-Noor, N., Daugbjerg, N., Moestrup, O., Anton, A., 2006. Marine epibenthic dinoflagellates from Malaysia - a study of five cultures and preserved samples based on light and scanning electron microscopy. Nordic Journal of Botany 24, 629-690.

Molgo, J., Benoit, E., Legrand, A.M., Kreger, A.S., 1997. Bioactive agents involved in fish poisoning: An overview, in: Seret, B., Sire, J.Y. (Eds.), 5th Indo-Pacific Fish Conference, Noumea, New Caledonia, pp. 721-738.

Molgo, J., Comella, J.X., Legrand, A.M., 1990. CIGUATOXIN ENHANCES QUANTAL TRANSMITTER RELEASE FROM FROG MOTOR-NERVE TERMINALS. Br. J. Pharmacol. 99, 695-700.

Molgo, J., Comella, J.X., Shimahara, T., Legrand, A.M., 1991. TETRODOTOXIN-SENSITIVE CIGUATOXIN EFFECTS ON QUANTAL RELEASE, SYNAPTIC VESICLE DEPLETION, AND CALCIUM MOBILIZATION. Annals of the New York Academy of Sciences 635, 485-488.

Molgo, J., Gaudrytalarmain, Y.M., Legrand, A.M., Moulian, N., 1993. CIGUATOXIN EXTRACTED FROM POISONOUS MORAY EELS GYMNOTHORAX-JAVANICUS TRIGGERS ACETYLCHOLINE-RELEASE FROM TORPEDO CHOLINERGIC SYNAPTOSOMES VIA REVERSED NA+-CA2+ EXCHANGE. Neurosci. Lett. 160, 65-68.

Molgo, J., Laurent, D., Pauillac, S., Chinain, M., Yeeting, B., 2010. Special issue on "Ciguatera and Related Biotoxins". Toxicon 56, 653-655.

Molgó, J., Laurent, D., Pauillac, S., Chinain, M., Yeeting, B., 2010. Special issue on “Ciguatera and Related Biotoxins”. Toxicon 56, 653-655.

Molgo, J., Shimahara, T., Legrand, A.M., 1993. CIGUATOXIN, EXTRACTED FROM POISONOUS MORAY EELS, CAUSES SODIUM-DEPENDENT CALCIUM MOBILIZATION IN NG108-15 NEUROBLASTOMA X GLIOMA HYBRID-CELLS. Neurosci. Lett. 158, 147-150.

Mooney, B.D., de Salas, M., Hallegraeff, G.M., Place, A.R., 2009. SURVEY FOR KARLOTOXIN PRODUCTION IN 15 SPECIES OF GYMNODINIOID DINOFLAGELLATES (KARENIACEAE, DINOPHYTA). J. Phycol. 45, 164-175.

Mooney, B.D., Hallegraeff, G.M., Place, A.R., 2010. Ichthyotoxicity of four species of gymnodinioid dinoflagellates (Kareniaceae, Dinophyta) and purified karlotoxins to larval sheepshead minnow. Harmful Algae 9, 557-562.

Moore, M.R., Ng, J.C., Lewis, R.J., 1997. Environmental poisoning: Presentation and management, 5th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Vancouver, Canada, pp. 502-509.

Morales, V., Vaca, L., 1999. The Maitotoxin induced calcium influx is modulated by Genistein. Faseb J. 13, A1559-A1559.

Morales-Tlalpan, V., Vaca, L., 2002. Modulation of the maitotoxin response by intracellular and extracellular cations. Toxicon 40, 493-500.

Morey, J.S., Ryan, J.C., Dechraoui, M.Y.B., Rezvani, A.H., Levin, E.D., Gordon, C.J., Ramsdell, J.S., Van Dolah, F.M., 2008. Liver genomic responses to ciguatoxin: Evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice. Toxicol. Sci. 103, 298-310.

Morita, M., Haketa, T., Koshino, H., Nakata, T., 2008. Synthetic studies on maitotoxin. 2. Stereoselective synthesis of the WXYZA '-ring system. Org. Lett. 10, 1679-1682.

Morita, M., Ishiyama, S., Koshino, H., Nakata, T., 2008. Synthetic studies on maitotoxin. 1. Stereoselective synthesis of the C ' D ' E ' F '-ring system having a side chain. Org. Lett. 10, 1675-1678.

Moriya, T., Furukawa, K.I., Nakamura, H., Murai, A., Ohizumi, Y., 2001. The vaso-contractile action of zooxanthellatoxin-B from a marine dinoflagellate is mediated via Ca2+ influx in the rabbit aorta. Canadian Journal of Physiology and Pharmacology 79, 1030-1035.

Moriya, T., Ishida, Y., Nakamura, H., Asari, T., Murai, A., Ohizumi, Y., 1998. Vasoconstriction induced by zooxanthellatoxin-B, a polyoxygenated long-chain product from a marine alga. Eur. J. Pharmacol. 350, 59-65.

Morris, J.G., 1990. Ciguatera fish poisoning: Baracuda's revenge. Southern Medical Journal [South. Med. J.] 83, 371-372.

Morris, J.G., 1999. Harmful algal blooms: An emerging public health problem with possible links to human stress on the environment. Annual Review of Energy and the Environment 24, 367-390.

Morton, S.L., Norris, D.R., Bomber, J.W., 1992. Effect of temperature, salinity and light intensity on the growth and seasonality of toxic dinoflagellates associated with ciguatera. Journal of Experimental Marine Biology and Ecology [J. Exp. Mar. Biol. Ecol.] 157, 79-90.

Morton, S.L., Norris, D.R., Bomber, J.W., 1992. EFFECT OF TEMPERATURE, SALINITY AND LIGHT-INTENSITY ON THE GROWTH AND SEASONALITY OF TOXIC DINOFLAGELLATES ASSOCIATED WITH CIGUATERA. J. Exp. Mar. Biol. Ecol. 157, 79-90.

Morton, S.L., Tindall, D.R., 1995. Morphological and biochemical variability of the toxic dinoflagellate Prorocentrum lima isolated from three locations at Heron Island, Australia. J. Phycology 31, 914-921.

Murakami, R., Yamamoto, K., Noguchi, T., 1999. Toxicity and paralytic shellfish poison composition of three species of bivalves collected in Ibaraki Prefecture, Japan. J. Food Hyg. Soc. Jpn. 40, 46-54.

Murata, M., 1991. POLYETHER COMPOUNDS FROM MARINE ORGANISMS. Nippon Nogeikagaku Kaishi-Journal of the Japan Society for Bioscience Biotechnology and Agrochemistry 65, 1743-1751.

Murata, M., Gusovsky, F., Sasaki, M., Yokoyama, A., Yasumoto, T., Daly, J.W., 1991. EFFECT OF MAITOTOXIN ANALOGS ON CALCIUM INFLUX AND PHOSPHOINOSITIDE BREAKDOWN IN CULTURED-CELLS. Toxicon 29, 1085-1096.

Murata, M., Gusovsky, F., Yasumoto, T., Daly, J.W., 1992. SELECTIVE STIMULATION OF CA-2+ FLUX IN CELLS BY MAITOTOXIN. European Journal of Pharmacology-Molecular Pharmacology Section 227, 43-49.

Murata, M., Iwashita, T., Yokoyama, A., Sasaki, M., Yasumoto, T., 1992. PARTIAL STRUCTURES OF MAITOTOXIN, THE MOST POTENT MARINE TOXIN FROM DINOFLAGELLATE GAMBIERDISCUS-TOXICUS. J. Am. Chem. Soc. 114, 6594-6596.

Murata, M., Legrand, A.M., Ishibashi, Y., Fukui, M., Yasumoto, T., 1990. Structures and configurations of ciguatoxin from the moray eel Gymnothorax javanicus and its likely precursor from the dinoflagellate Gambierdiscus toxicus. J. Am. Chem. Soc. 112, 4380-4386.

Murata, M., Legrand, A.M., Ishibashi, Y., Fukui, M., Yasumoto, T., 1990. STRUCTURES AND CONFIGURATIONS OF CIGUATOXIN FROM THE MORAY EEL GYMNOTHORAX-JAVANICUS AND ITS LIKELY PRECURSOR FROM THE DINOFLAGELLATE GAMBIERDISCUS-TOXICUS. J. Am. Chem. Soc. 112, 4380-4386.

Murata, M., Legrand, A.M., Ishibashi, Y., Yasumoto, T., 1989. Structures of ciguatoxin and its congener. J. Am. Chem. Soc. 111, 8929-8931.

Murata, M., Legrand, A.M., Scheuer, P.J., Yasumoto, T., 1992. C-13 NMR ASSIGNMENTS OF CIGUATOXIN BY INVERSE-DETECTED 2D-SPECTROSCOPY AND AN EXPLANATION OF NMR SIGNAL BROADENING. Tetrahedron Lett. 33, 525-526.

Murata, M., Legrand, A.M., Yasumoto, T., 1989. A PROBABLE PARTIAL STRUCTURE OF CIGUATOXIN ISOLATED FROM THE MORAY EEL GYMNOTHORAX-JAVANICUS. Tetrahedron Lett. 30, 3793-3796.

Murata, M., Legrand, A.N., Ishibashi, Y., Fukui, M., Yasumoto, T., 1990. CONFORMATIONS OF CIGUATOXIN AND RELATED POLYETHERS. Abstracts of Papers of the American Chemical Society 200, 54-AGFD.

Murata, M., Matsumori, N., Konoki, K., Oishi, T., 2008. Structural features of dinotlagellate toxins underlying biological activity as viewed by NMR. Bull. Chem. Soc. Jpn. 81, 307-319.

Murata, M., Matsumori, N., Tachibana, K., 1997. Analysis of relative configuration of acyclic compounds based on long-range carbon-proton coupling constants determined by two dimensional NMR. Nippon Kagaku Kaishi, 749-757.

Murata, M., Naoki, H., Iwashita, T., Matsunaga, S., Sasaki, M., Yokoyama, A., Yasumoto, T., 1993. STRUCTURE OF MAITOTOXIN. J. Am. Chem. Soc. 115, 2060-2062.

Murata, M., Naoki, H., Matsunaga, S., Satake, M., Yasumoto, T., 1994. STRUCTURE AND PARTIAL STEREOCHEMICAL ASSIGNMENTS FOR MAITOTOXIN, THE MOST TOXIC AND LARGEST NATURAL NON-BIOPOLYMER. J. Am. Chem. Soc. 116, 7098-7107.

Murata, M., Yasumoto, T., 1995. STRUCTURE OF MAITOTOXIN, THE MOST TOXIC AND LARGEST NATURAL NON-BIOPOLYMER. J. Synth. Org. Chem. Jpn. 53, 207-217.

Murata, M., Yasumoto, T., 2000. The structure elucidation and biological activities of high molecular weight algal toxins: maitotoxin, prymnesins and zooxanthellatoxins. Nat. Prod. Rep. 17, 293-314.

Musgrave, I.F., Seifert, R., Schultz, G., 1994. MAITOTOXIN ACTIVATES CATION CHANNELS DISTINCT FROM THE RECEPTOR-ACTIVATED NONSELECTIVE CATION CHANNELS OF NL-60 CELLS. Biochem. J. 301, 437-441.

Musgrave, I.F., Seifert, R., Schultz, G., 1994. MATIOTOXIN STIMULATES CALCIUM INFLUX IN HL-60 CELLS THROUGH A PATHWAY DISTINCT FROM RECEPTOR-ACTIVATED NONSELECTIVE CATION CHANNELS. Br. J. Pharmacol. 112, U214-U214.

Naar, J.P., Flewelling, L.J., Lenzi, A., Abbott, J.P., Granholm, A., Jacocks, H.M., Gannon, D., Henry, M.S., Pierce, R.H., Baden, D.G., Wolny, J., Landsberg, J.H., 2007. Brevetoxins, like ciguatoxins, are potent ichthyotoxic neurotoxins that accumulate in fish. Toxicon 50, 707-723.

Nagai, H., Satake, M., Yasumoto, T., 1990. ANTIMICROBIAL ACTIVITIES OF POLYETHER COMPOUNDS OF DINOFLAGELLATE ORIGINS. J. Appl. Phycol. 2, 305-308.

Nagasawa, K., Hori, N., Koshino, H., Nakata, T., 1999. Rearrangement reaction of tetrahydrofurans and tetrahydropyrans having a C1 '-mesyloxy group on the C2-side chain with zinc acetate. Heterocycles 50, 919-928.

Nagasawa, K., Hori, N., Shiba, R., Nakata, T., 1997. Rearrangement-ring expansion reaction of functionalized cyclic ethers. Stereoselective synthesis of the ST- and XY-ring systems of maitotoxin. Heterocycles 44, 105-110.

Nagumo, S., Ishii, Y., Sato, G., Mizukami, M., Imai, M., Kawahara, N., Akita, H., 2009. 8-Endo selective Friedel-Crafts cyclization of vinyloxiranes with Co-2(CO)(6)-complexed acetylene. Tetrahedron Lett. 50, 26-28.

Nagumo, Y., Oguri, H., Shindo, Y., Sasaki, S., Oishi, T., Hirama, M., Tomioka, Y., Mizugaki, M., Tsumuraya, T., 2001. Concise synthesis of ciguatoxin ABC-ring fragments and surface plasmon resonance study of the interaction of their BSA conjugates with monoclonal antibodies. Bioorg. Med. Chem. Lett. 11, 2037-2040.

Nagumo, Y., Oguri, H., Tsumoto, K., Shindo, Y., Hirama, M., Tsumuraya, T., Fujii, I., Tomioka, Y., Mizugaki, M., Kumagai, I., 2004. Phage-display selection of antibodies to the left end of CTX3C using synthetic fragments. J. Immunol. Methods 289, 137-146.

Nakahata, N., Ohkubo, S., Ito, E., Nakano, M., Terao, K., Ohizumi, Y., 1999. Comparison of maitotoxin with thromboxane A(2) in rabbit platelet activation. Toxicon 37, 1375-1389.

Nakahata, N., Yaginuma, T., Ohizumi, Y., 1999. Maitotoxin-induced phosphoinositide hydrolysis is dependent on extracellular but not intracellular Ca2+ in human astrocytoma cells. Japanese Journal of Pharmacology 81, 240-243.

Nakamura, H., Asari, T., Murai, A., Kan, Y., Kondo, T., Yoshida, K., Ohizumi, Y., 1995. ZOOXANTHELLATOXIN-A, A POTENT VASOCONSTRICTIVE 62-MEMBERED LACTONE FROM A SYMBIOTIC DINOFLAGELLATE. J. Am. Chem. Soc. 117, 550-551.

Nakamura, H., Asari, T., Ohizumi, Y., Kobayashi, J., Yamasu, T., Murai, A., 1993. ISOLATION OF ZOOXANTHELLATOXINS, NOVEL VASOCONSTRICTIVE SUBSTANCES FROM THE ZOOXANTHELLA SYMBIODINIUM SP. Toxicon 31, 371-376.

Nakata, T., 2008. Efficient methods for synthesis of polycyclic ethers and their application. J. Synth. Org. Chem. Jpn. 66, 344-357.

Nakata, T., 2010. SmI2-induced Cyclizations and Their Applications in Natural Product Synthesis. Chem. Rec. 10, 159-172.

Nakata, T., Nomura, S., Matsukura, H., 1996. Stereoselective synthesis of the S- and Y-ring systems of maitotoxin. Chemical & Pharmaceutical Bulletin 44, 627-629.

Naoki, H., 1997. Structural analysis of polyether compounds by MS/MS method. Gendai Kagaku Zokan 31, 121-130.

Naoki, H., Murata, M., Yasumoto, T., 1993. NEGATIVE-ION FAST-ATOM-BOMBARDMENT TANDEM MASS-SPECTROMETRY FOR THE STRUCTURAL STUDY OF POLYETHER COMPOUNDS - STRUCTURAL VERIFICATION OF YESSOTOXIN. Rapid Commun. Mass Spectrom. 7, 179-182.

Nath, R., Davis, M., Probert, A.W., Kupina, N.C., Ren, X.D., Schielke, G.P., Wang, K.K.W., 2000. Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells. Biochem. Biophys. Res. Commun. 274, 16-21.

Nath, R., Raser, K.J., Stafford, D., Hajimohammadreza, I., Posner, A., Allen, H., Talanian, R.V., Yuen, P.W., Gilbertsen, R.B., Wang, K.K.W., 1996. Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: Contributory roles of both protease families in neuronal apoptosis. Biochem. J. 319, 683-690.

Naves, J.L., Prado, M.P., Rangel, M., De Sanctis, B., Machado-Santelli, G., Freitas, J.C., 2006. Cytotoxicity in the marine dinoflagellate Prorocentrum mexicanum from Brazil. Comp. Biochem. Physiol. C-Toxicol. Pharmacol. 143, 73-77.

Nedrelow, J.H., Cianci, C.D., Morrow, J.S., 2003. C-src binds alpha II spectrin's Src homology 3 (SH3) domain and blocks calpain susceptibility by phosphorylating Tyr(1176). J. Biol. Chem. 278, 7735-7741.

neurosciences, è.r.e.t.R.S.p.l.é.d.t.a.S.w.t.S.d., 1999. Paris, France, 9-11 December 1998. Toxicology 37, 1201-1239.

Newcomb-Fernandez, J.K., Zhao, X.R., Pike, B.R., Wang, K.K.W., Kampfl, A., Beer, R., DeFord, S.M., Hayes, R.L., 2001. Concurrent assessment of calpain and caspase-3 activation after oxygen-glucose deprivation in primary septo-hippocampal cultures. Journal of Cerebral Blood Flow and Metabolism 21, 1281-1294.

Nguyen-Huu, T.D., Mattei, C., Wen, P.J., Bourdelais, A.J., Lewis, R.J., Benoit, E., Baden, D.G., Molgo, J., Meunier, F.A., 2010. Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal. Toxicon 56, 792-796.

Nguyen-Huu, T.D., Mattei, C., Wen, P.J., Bourdelais, A.J., Lewis, R.J., Benoit, E., Baden, D.G., Molgó, J., Meunier, F.A., 2010. Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal. Toxicon 56, 792-796.

Nicholson, G.M., Lewis, R.J., 2006. Ciguatoxins: Cyclic polyether modulators of voltage-gated ion channel function. Mar. Drugs 4, 82-118.

Nicholson, G.M., Little, M.J., Birinyi-Strachan, L.C., 2004. Structure and function of delta-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel. Toxicon 43, 587-599.

Nicolaou, K.C., Aversa, R.J., 2011. Maitotoxin: An Inspiration for Synthesis. Isr. J. Chem. 51, 359-377.

Nicolaou, K.C., Aversa, R.J., Jin, J., Rivas, F., 2010. Synthesis of the ABCDEFG Ring System of Maitotoxin. J. Am. Chem. Soc. 132, 6855-6861.

Nicolaou, K.C., Baker, T.M., Nakamura, T., 2011. Synthesis of the WXYZA ' Domain of Maitotoxin. J. Am. Chem. Soc. 133, 220-226.

Nicolaou, K.C., Cole, K.P., Frederick, M.O., Aversa, R.J., Denton, R.M., 2007. Chemical synthesis of the GHIJK ring system and further experimental support for the originally assigned structure of maitotoxin. Angew. Chem.-Int. Edit. 46, 8875-8879.

Nicolaou, K.C., Frederick, M.O., 2007. On the structure of maitotoxin. Angew. Chem.-Int. Edit. 46, 5278-5282.

Nicolaou, K.C., Frederick, M.O., Burtoloso, A.C.B., Denton, R.M., Rivas, F., Cole, K.P., Aversa, R.J., Gibe, R., Umezawa, T., Suzuki, T., 2008. Chemical synthesis of the GHIJKLMNO ring system of maitotoxin. J. Am. Chem. Soc. 130, 7466-7476.

Nicolaou, K.C., Gelin, C.F., Seo, J.H., Huang, Z.H., Umezawa, T., 2010. Synthesis of the QRSTU Domain of Maitotoxin and Its 85-epi- and 86-epi-Diastereoisomers. J. Am. Chem. Soc. 132, 9900-9907.

Nicolaou, K.C., Postema, M.H.D., Yue, E.W., Nadin, A., 1996. An olefin metathesis based strategy for the construction of the JKL, OPQ, and UVW ring systems of maitotoxin. J. Am. Chem. Soc. 118, 10335-10336.

Nicolaou, K.C., Sato, M., Miller, N.D., Gunzner, J.L., Renaud, J., Untersteller, E., 1996. Copper(I)-promoted Stille cross-coupling of stannyl enol ethers with enol triflates: Construction of complex polyether frameworks. Angewandte Chemie-International Edition in English 35, 889-891.

Nicolaou, K.C., Seo, J.H., Nakamura, T., Aversa, R.J., 2011. Synthesis of the C ' D ' E ' F ' Domain of Maitotoxin. J. Am. Chem. Soc. 133, 214-219.

Nicolaou, K.C., Vega, J.A., Vassilikogiannakis, G., 2001. cis-3,4-dichlorocyclobutene as a versatile synthon in organic synthesis. Rapid entry into complex polycyclic systems with remarkably stereospecific reactions. Angew. Chem.-Int. Edit. 40, 4441-+.

Niitsu, A., Harada, M., Yamagaki, T., Tachibana, K., 2008. Conformations of 3-carboxylic esters essential for neurotoxicity in veratrum alkaloids are loosely restricted and fluctuate. Bioorg. Med. Chem. 16, 3025-3031.

Niki, I., Tamagawa, T., Niki, H., Niki, A., Koide, T., Sakamoto, N., 1986. STIMULATION OF INSULIN RELEASE BY MAITOTOXIN, AN ACTIVATOR OF VOLTAGE-DEPENDENT CALCIUM CHANNELS. Biomed. Res. 7, 107-112.

Nishimura, T., Hariganeya, N., Tawong, W., Sakanari, H., Yamaguchi, H., Adachi, M., 2016. Quantitative PCR assay for detection and enumeration of ciguatera-causing dinoflagellate Gambierdiscus spp. (Gonyaulacales) in coastal areas of Japan. Harmful Algae 52, 11-22.

Nishimura, T., Sato, S., Tawong, W., Sakanari, H., Uehara, K., Shah, M.M.R., Suda, S., Yasumoto, T., Taira, Y., Yamaguchi, H., Adachi, M., 2013. Genetic Diversity and Distribution of the Ciguatera-Causing Dinoflagellate <italic>Gambierdiscus</italic> spp. (Dinophyceae) in Coastal Areas of Japan. PLoS One 8, e60882.

Nishimura, T., Sato, S., Tawong, W., Sakanari, H., Uehara, K., Shah, M.M.R., Suda, S., Yasumoto, T., Taira, Y., Yamaguchi, H., Adachi, M., 2013. Genetic Diversity and Distribution of the Ciguatera-Causing Dinoflagellate Gambierdiscus spp. (Dinophyceae) in Coastal Areas of Japan. PLoS One 8.

Nishio, M., Kigoshi, S., Muramatsu, I., Yasumoto, T., 1993. CA2+-DEPENDENT AND NA+-DEPENDENT DEPOLARIZATION-INDUCED BY MAITOTOXIN IN THE CRAYFISH GIANT-AXON. General Pharmacology 24, 1079-1083.

Nishio, M., Muramatsu, I., Yasumoto, T., 1996. Na+-permeable channels induced by maitotoxin in guinea-pig single ventricular cells. Eur. J. Pharmacol. 297, 293-298.

Nishiyama, I., Matsui, T., Yasumoto, T., Oshio, S., Hoshi, M., 1986. MAITOTOXIN, A PRESUMED CALCIUM-CHANNEL ACTIVATOR, INDUCES THE ACROSOME REACTION IN MUSSEL SPERMATOZOA. Development Growth & Differentiation 28, 443-448.

Nishiyama, I., Yasumoto, T., Fujii, T., 1990. MAITOTOXIN INDUCES CALCITONIN SECRETION FROM RAT-THYROID C-CELLS INVITRO. Hormone and Metabolic Research 22, 258-259.

Nogoshi, K., Domon, D., Fujiwara, K., Kawamura, N., Katoono, R., Kawai, H., Suzuki, T., 2013. An Ireland-Claisen rearrangement/RCM based approach for the construction of the EF-ring of ciguatmdn 3C. Tetrahedron Lett. 54, 676-680.

Noguchi, T., 1993. Recent studies on marine toxins. Jpn. J. Toxicol. Environ. Health 39, 81-93.

Noguchi, T., 2003. Marine toxins. Nippon Suisan Gakkaishi 69, 895-909.

Nonomura, T., Sasaki, M., Matsumori, N., Murata, M., Tachibana, K., Yasumoto, T., 1996. The complete structure of maitotoxin .2. Configuration of the C135-C142 side chain and absolute configuration of the entire molecule. Angewandte Chemie-International Edition in English 35, 1675-1678.

Nonoyama, A., Hamajima, A., Isobe, M., 2007. Synthesis of symmetric HIJ-ring model of ciguatoxin, 8th Tetrahedron Symposium on Challenges in Organic Chemistry. Pergamon-Elsevier Science Ltd, Berlin, GERMANY, pp. 5886-5894.

Norris, D.R., Bomber , J.W., Balech, E., 1985. Benthic dinoflagellates associated with ciguatera from the Florida keys. I. Ostreopsis heptagona sp. nov., in: Anderson, D.M., White , A.W., Baden, D.G. (Eds.), Toxic Dinoflagellates. Elsevier, New York, NY, pp. 39-44.

Nukina, M., Koyanagi, L.M., Scheuer, P.J., 1984. 2 INTERCHANGEABLE FORMS OF CIGUATOXIN. Toxicon 22, 169-176.

Nukina, M., Tachibana, K., Koyanagi, L.M., Scheuer, P.J., 1983. STRUCTURAL STUDIES ON CIGUATOXIN. Abstracts of Papers of the American Chemical Society 186, 135-AGFD.

Obara, Y., Takahashi, M., Nakahata, N., Ohizumi, Y., 1999. Maitotoxin-induced nerve growth factor production accompanied by the activation of a voltage-insensitive Ca2+ channel in C6-BU-1 glioma cells. Br. J. Pharmacol. 127, 1577-1582.

Ochoa, J.L., SanchezPaz, A., CruzVillacorta, A., NunezVazquez, E., SierraBeltran, A., 1996. Toxic events in the northwest Pacific coastline of Mexico during 1992-1995: origin and impact, Asia-Pacific Conference on Science and Management of Coastal Environment, Hong Kong, Hong Kong, pp. 195-200.

Ogura, A., Ohizumi, Y., Yasumoto, T., 1984. CALCIUM-DEPENDENT DEPOLARIZATION INDUCED BY A MARINE TOXIN, MAITOTOXIN, IN A NEURONAL CELL. Japanese Journal of Pharmacology 36, P315-P315.

Oguri, H., 2007. Bioorganic studies utilizing rationally designed synthetic molecules: Absolute configuration of ciguatoxin and development of immunoassay systems. Bull. Chem. Soc. Jpn. 80, 1870-1883.

Oguri, H., Hirama, M., Tsumuraya, T., Fujii, I., Maruyama, M., Uehara, H., Nagumo, Y., 2003. Synthesis-based approach toward direct sandwich immunoassay for ciguatoxin CTX3C. J. Am. Chem. Soc. 125, 7608-7612.

Oguri, H., Hishayama, S., Sato, O., Oishi, T., Hirama, M., Murata, M., Yasumoto, T., Harada, N., 1997. Synthetic study of ciguatoxin: absolute configuration of the C2 hydroxy group. Tetrahedron 53, 3057-3072.

Oguri, H., Hishiyama, S., Oishi, T., Hirama, M., 1995. ENANTIOCONTROLLED SYNTHESIS OF THE AB RING MOIETY OF CIGUATOXIN. Synlett, 1252-&.

Oguri, H., Hishiyama, S., Sato, O., Oishi, T., Hirama, M., Murata, M., Yasumoto, T., Harada, N., 1997. Synthetic study of ciguatoxin. Absolute configuration of the C2 hydroxy group. Tetrahedron 53, 3057-3072.

Oguri, H., Sasaki, S., Oishi, T., Hirama, M., 1999. Expeditious tandem-metathesis route to the AB-ring fragment of ciguatoxin. Tetrahedron Lett. 40, 5405-5408.

Oguri, H., Tanaka, S., Hishiyama, S., Oishi, T., Hirama, M., Tumuraya, T., Tomioka, Y., Mizugaki, M., 1999. Designed hapten aimed at anti-ciguatoxin monoclonal antibody: Synthesis, immunization and discrimination of the C2 configuration. Synthesis-Stuttgart, 1431-1436.

Oguri, H., Tanaka, S., Oishi, T., Hirama, M., 2000. A very short route to the functionalized A-ring moiety of ciguatoxin. Tetrahedron Lett. 41, 975-978.

Oh, H.S., Yun, J.S., Nah, K.H., Kang, H.Y., Sherman, D.H., 2007. Synthesis of the tetraketide lactones from the pikromycin biosynthetic pathway. Eur. J. Org. Chem., 3369-3379.

Ohizumi, Y., 1987. PHARMACOLOGICAL ACTIONS OF THE MARINE TOXINS CIGUATOXIN AND MAITOTOXIN ISOLATED FROM POISONOUS FISH. Biol. Bull. 172, 132-136.

Ohizumi, Y., 1996. Pharmacological studies of physiologically active substances isolated from marine organisms. Journal of Toxicology-Toxin Reviews 15, 109-128.

Ohizumi, Y., Ishida, Y., Shibata, S., 1982. MODE OF THE CIGUATOXIN-INDUCED SUPER-SENSITIVITY IN THE GUINEA-PIG VAS-DEFERENS. J. Pharmacol. Exp. Ther. 221, 748-752.

Ohizumi, Y., Kajiwara, A., Yasumoto, T., 1983. EXCITATORY EFFECT OF THE MOST POTENT MARINE TOXIN, MAITOTOXIN, ON THE GUINEA-PIG VAS-DEFERENS. J. Pharmacol. Exp. Ther. 227, 199-204.

Ohizumi, Y., Kajiwara, A., Yasumoto, T., 1983. MODE OF THE NORADRENALINE RELEASE INDUCED BY MAITOTOXIN, THE PRINCIPAL TOXIN OF POISONOUS FISHES INHABITING TROPICAL SEAS, FROM ADRENERGIC-NERVES. Folia Pharmacologica Japonica 82, P158-P158.

Ohizumi, Y., Kajiwara, A., Yasumoto, T., 1984. CA-2+-DEPENDENT CONTRACTILE RESPONSE OF INTESTINAL SMOOTH-MUSCLE TO MAITOTOXIN, A MARINE TOXIN. Folia Pharmacologica Japonica 83, P96-P96.

Ohizumi, Y., Kajiwara, A., Yasumoto, T., 1984. EFFECTS OF VARIOUS CA ANTAGONISTS AND DIVALENT-CATIONS ON THE CONTRACTILE RESPONSE TO MAITOTOXIN, A MARINE TOXIN. Japanese Journal of Pharmacology 36, P184-P184.

Ohizumi, Y., Kobayashi, M., 1990. CA-DEPENDENT EXCITATORY EFFECTS OF MAITOTOXIN ON SMOOTH AND CARDIAC-MUSCLE. Acs Symposium Series 418, 133-143.

Ohizumi, Y., Shibata, S., Tachibana, K., 1981. MODE OF THE EXCITATORY AND INHIBITORY ACTIONS OF CIGUATOXIN IN THE GUINEA-PIG VAS-DEFERENS. J. Pharmacol. Exp. Ther. 217, 475-480.

Ohizumi, Y., Takahashi, M., Tatsumi, M., Kajiwara, A., Shibata, S., Yasumoto, T., 1984. PHARMACOLOGICAL ACTIONS OF MARINE TOXINS, MAITOTOXIN AND PALYTOXIN. Japanese Journal of Pharmacology 36, P29-P29.

Ohizumi, Y., Yasumoto, T., 1983. CONTRACTILE RESPONSE OF THE RABBIT AORTA TO MAITOTOXIN, THE MOST POTENT MARINE TOXIN. J. Physiol.-London 337, 711-721.

Ohizumi, Y., Yasumoto, T., 1983. CONTRACTION AND INCREASE IN TISSUE CALCIUM CONTENT INDUCED BY MAITOTOXIN, THE MOST POTENT KNOWN MARINE TOXIN, IN INTESTINAL SMOOTH-MUSCLE. Br. J. Pharmacol. 79, 3-5.

Oishi, T., 2003. Total synthesis of ciguatoxin CTX3C. J. Synth. Org. Chem. Jpn. 61, 562-571.

Oishi, T., 2012. Convergent Method via alpha-Cyano Ethers: A Powerful Strategy for Synthesizing Ladder-Shaped Polyethers. J. Synth. Org. Chem. Jpn. 70, 1170-1177.

Oishi, T., Konoki, K., Tamate, R., Torikai, K., Hasegawa, F., Matsumori, N., Murata, M., 2012. Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca2+ influx in rat glioma C6 cells. Bioorg. Med. Chem. Lett. 22, 3619-3622.

Oishi, T., Maeda, K., Hirama, M., 1997. Stereocontrolled synthesis of the HIJ ring system of ciguatoxin. Chem. Commun., 1289-1290.

Oishi, T., Maruyama, M., Shoji, M., Maeda, K., Kumahara, N., Tanaka, S., Hirama, M., 1999. Enantioselective synthesis of the medium ring ethers, tetrahydrooxepin, oxocane and hexahydrooxonin, of ciguatoxin. Extensive ring-expansion and chemoenzymatic desymmetrization strategy. Tetrahedron 55, 7471-7498.

Oishi, T., Nagumo, Y., Shoji, M., Le Brazidec, J.Y., Uehara, H., Hirama, M., 1999. Convergent synthesis of the IJKLM ring fragment of ciguatoxin CTX3C. Chem. Commun., 2035-2036.

Oishi, T., Shoji, M., Kumahara, N., Hirama, M., 1997. Stereoselective synthesis of the LM ring moiety of ciguatoxin: Reagent control of asymmetric dihydroxylation. Chem. Lett., 845-846.

Oishi, T., Shoji, M., Maeda, K., Kumahara, N., Hirama, M., 1996. Extensive ring-expansion strategy for the enantioselective synthesis of the medium ring ethers, oxepene, oxocane, and oxonene, of ciguatoxin. Synlett, 1165-&.

Oishi, T., Suzuki, M., Watanabe, K., Murata, M., 2006. Convergent synthesis of the CDEF ring fragment of yessotoxin via alpha-cyano ethers. Heterocycles 69, 91-+.

Oishi, T., Tanaka, S., Ogasawara, Y., Maeda, K., Oguri, H., Hirama, M., 2001. Highly stereocontrolled synthesis of the ABCD ring fragment of ciguatoxin CTX3C. Synlett, 952-954.

Oishi, T., Torikai, K., Hasegawa, F., 2009. Design and Synthesis of Ladder-Shaped Polyethers and Evaluation of the Interaction with Transmembrane Proteins. J. Synth. Org. Chem. Jpn. 67, 1250-1260.

Oishi, T., Uehara, H., Nagumo, Y., Shoji, M., Le, B.-J.Y., Kosaka, M., Hirama, M., 2001. : Practical entry into the HIJKLM ring segment of ciguatoxin CTX3C. : Chemical Communications 4, 381-382.

Oishi, T., Uehara, H., Nagumo, Y., Shoji, M., Le Brazidec, J.Y., Kosaka, M., Hirama, M., 2001. Practical entry into the HIJKLM ring segment of ciguatoxin CTX3C. Chem. Commun., 381-382.

Oka, T., Fujiwara, K., Murai, A., 1996. Synthesis of both enantiomers of the BC-ring part of ciguatoxin. Tetrahedron 52, 12091-12110.

Oka, T., Fujiwara, K., Murai, A., 1997. The construction of the A,B,C-ring system of ciguatoxin. Tetrahedron Lett. 38, 8053-8056.

Oka, T., Fujiwara, K., Murai, A., 1998. Synthetic studies on ciguatoxin - [2]; Synthesis of the A,B,C-ring system. Tetrahedron 54, 21-44.

Oka, T., Fujiwara, K., Murai, A., 1998. Synthetic studies on ciguatoxin; synthesis of the A, B, C-ring system. Tetrahedron 54, 21-44.

Oka, T., Murai, A., 1994. CONSTRUCTION OF THE C46-C55 FRAGMENT OF CIGUATOXIN. Chem. Lett., 1611-1614.

Oka, T., Murai, A., 1998. Synthetic studies on ciguatoxin - [1]; Construction of the spiro acetal part (C46-C55). Tetrahedron 54, 1-20.

Oka, T., Murai, A., 1998. Synthetic studies on ciguatoxin; construction of the spiro acetal part (C46-C55). Tetrahedron 54, 1-20.

Okada, K., Niwa, M., 1998. Marine toxins implicated in food poisoning. Journal of Toxicology-Toxin Reviews 17, 373-384.

Okumura, M., Tzusuki, H., Tomita, B.-I., 2005. A rapid detection method for paralytic shellfish poisoning toxins by cell bioassay. Toxicon [Toxicon] 46, 93-98.

Olivi, L., Bressler, J., 2000. Maitotoxin stimulates Cd influx in Madin-Darby kidney cells by activating Ca-permeable cation channels. Cell Calcium 27, 187-193.

Osek, J., Wieczorek, K., Tatarczak, M., 2006. Seafood as potential source of poisoning by marine biotoxins. Med. Weter. 62, 370-373.

Oshiro, N., Yogi, K., Asato, S., Sasaki, T., Tamanaha, K., Hirama, M., Yasumoto, T., Inafuku, Y., 2010. Ciguatera incidence and fish toxicity in Okinawa, Japan. Toxicon 56, 656-661.

Otero, P., Perez, S., Alfonso, A., Vale, C., Rodriguez, P., Gouveia, N.N., Gouveia, N., Delgado, J., Vale, P., Hirama, M., Ishihara, Y., Molgo, J., Botana, L.M., 2010. First Toxin Profile of Ciguateric Fish in Madeira Arquipelago (Europe). Anal. Chem. 82, 6032-6039.

Otero, P., Pérez, S., Alfonso, A., Vale, C., Rodríguez, P., Gouveia, N.N., Gouveia, N., Delgado, J., Vale, P., Hirama, M., Ishihara, Y., Molgó, J., Botana, L.M., 2010. First Toxin Profile of Ciguateric Fish in Madeira Arquipelago (Europe). Anal. Chem. 82, 6032-6039.

O'Toole, A.C., Bottein, M.Y.D., Danylchuk, A.J., Ramsdell, J.S., Cooke, S.J., 2012. Linking ciguatera poisoning to spatial ecology of fish: A novel approach to examining the distribution of biotoxin levels in the great barracuda by combining non-lethal blood sampling and biotelemetry. Sci. Total Environ. 427, 98-105.

O'Toole, A.C., Bottein, M.-Y.D., Danylchuk, A.J., Ramsdell, J.S., Cooke, S.J., 2012. Linking ciguatera poisoning to spatial ecology of fish: A novel approach to examining the distribution of biotoxin levels in the great barracuda by combining non-lethal blood sampling and biotelemetry. Sci. Total Environ. 427, 98-105.

P.J., S., 1982. Marine Ecology - some chemical aspects. Naturwissenschaften 69, 528-533.

Palafox, N.A., Buenconsejo-Lum, L.E., 2001. Ciguatera fish poisoning: Review of clinical manifestations. Journal of Toxicology-Toxin Reviews 20, 141-160.

Parc, F., Ducousso, R., Chanteau, S., Chunge, E., Bagnis, R., 1979. Problems linked to the ciguatoxin immunological detection. Toxicon [Toxicon] 17, 137.

Paredes, I., Rietjens, I.M.C.M., Vieites, J.M., Cabado, A.G., 2011. Update of risk assessments of main marine biotoxins in the European Union. Toxicon 58, 336-354.

Park, D.L., 1992. SURVEILLANCE PROGRAMS FOR MANAGING RISKS FROM NATURALLY-OCCURRING TOXICANTS, 8th International IUPAC (International-Union-of-Pure-and-Applied-Chemistry) Symposium on Mycotoxins and Phycotoxins, Mexico City, Mexico, pp. 361-371.

Park, D.L., 1993. DETECTION OF CIGUATERA AND DIARRHEIC SHELLFISH TOXINS IN FINFISH AND SHELLFISH WITH CIGUATECT KIT, Symposium on Analytical Methods for Seafood Toxins, at the 107th AOAC International Annual Meeting, Washington, Dc, pp. 533-537.

Park, D.L., 1993. Use of okadaic acid as positive control in testing for ciguatoxin. PCT Int. Appl., 26 pp.

Park, D.L., 1994. Evolution of methods for assessing ciguatera toxins in fish. Reviews of Environmental Conamination and Toxicology [Rev. Environ. Contam. T.] 136, 1-20.

Park, D.L., 1995. Detection of ciguaterra and diarrhetic shellfish toxins in finfish and shellfish with ciguatect kit. Journal of the Association of Official Analytical Chemists International [J. Assoc. Off. Anal. Chem. Int.] 78, 533-537.

Park, D.L., 1995. Surveillance programmes for managing risks from naturally occurring toxicants. Food Addit. Contam. 12, 361-371.

Park, D.L., Fremy, J.M., Marcaillou-LeBaut, C., Gleizes, E., Masselin, P., Goldsmith, C.H., 1995. Utilization of solid-phase immunobead assay to monitor fish and shellfish harvesting areas for ciguatera fish and diarrhetic shellfish poisoning toxins, in: Lassus, P., Arzul, G., Erard, E., Gentien, P., Marcaillou, C. (Eds.), Harmful Marine Algal Blooms. Lavoisier Intercept Ltd., pp. 327-332.

Park, D.L., Gamboa, P.M., Goldsmith, C.H., 1992. Rapid facile solid-phase immunobead assay for sreening ciguatoxic fish in the market place. Bull. Soc. Path. Ex. 85, 504-507.

Park, J.Y., Jung, S.H., Jung, J.W., Kwon, M.H., Yoo, J.O., Kim, Y.M., Ha, K.S., 2009. A novel array-based assay of in situ tissue transglutaminase activity in human umbilical vein endothelial cells. Anal. Biochem. 394, 217-222.

Parsons, M.L., Aligizaki, K., Bottein, M.-Y.D., Fraga, S., Morton, S.L., Penna, A., Rhodes, L., 2012. Gambierdiscus and Ostreopsis: Reassessment of the state of knowledge of their taxonomy, geography, ecophysiology, and toxicology. Harmful Algae 14, 107-129.

Parsons, M.L., Preskitt, L.B., 2007. A survey of epiphytic dinoflagellates from the coastal waters of the island of Hawai'i. Harmful Algae 6, 658-669.

Parsons, M.L., Settlemier, C.J., Ballauer, J.M., 2011. An examination of the epiphytic nature of Gambierdiscus toxicus, a dinoflagellate involved in ciguatera fish poisoning. Harmful Algae 10, 598-605.

Parsons, M.L., Settlemier, C.J., Bienfang, P.K., 2010. A simple model capable of simulating the population dynamics of Gambierdiscus, the benthic dinoflagellate responsible for ciguatera fish poisoning. Harmful Algae 10, 71-80.

Pauillac, S., Bléhaut, J., Cruchet, P., Lotte, C., Legrand, A.-M., 1993

1995. Recent advances in detection of ciguatoxins in French Polynesia, in: Lassus, P., Arzul, G., Erard, E., Gentien, P., Marcaillou, C. (Eds.), Harmful Marine Algal Blooms. Lavoisier, Intercept Ltd., Nantes, pp. 801-808.

Pauillac, S., Sasaki, M., Inoue, M., Naar, J., Branaa, P., Chinain, M., Tachibana, K., Legrand, A.M., 2000. Characterization of mice antisera elicited with a ciguatoxin tetracyclic synthetic ring fragment (JKLM) conjugated to carrier proteins. Toxicon 38, 669-685.

Pauillac, S., Sasaki, M., Naar, J., Inoue, M., Branaa, P., Cruchet, P., Chinain, M., Legrand, A.M., 1997. Immunochemical methods for ciguatoxins detection in Pacific herbivorous and carnivorous fish, in: Seret, B., Sire, J.Y. (Eds.), 5th Indo-Pacific Fish Conference, Noumea, New Caledonia, pp. 759-773.

Paz, B., Riobo, P., Franco, J.M., 2011. Preliminary study for rapid determination of phycotoxins in microalgae whole cells using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 25, 3627-3639.

Pazos, M.J., Alfonso, A., Vieytes, M.R., Yasumoto, T., Botana, L.M., 2005. Kinetic analysis of the interaction between yessotoxin and analogues and immobilized phosphodiesterases using a resonant mirror optical biosensor. Chem. Res. Toxicol. 18, 1155-1160.

Pearn, J., 2001. Neurology of ciguatera. Journal of Neurology Neurosurgery and Psychiatry 70, 4-8.

Pelegrin, P., Surprenant, A., 2007. Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1 beta release through a dye uptake-independent pathway. J. Biol. Chem. 282, 2386-2394.

Peng, J., Place, A.R., Yoshida, W.Y., Anklin, C., Hamann, M.T., 2010. Structure and Absolute Configuration of Karlotoxin-2, an Ichthyotoxin from the Marine Dinoflagellate Karlodinium veneficum. J. Am. Chem. Soc. 132, 3277-3279.

Peng, Y.G., Taylor, T.B., Finch, R.E., Moeller, P.D., Ramsdell, J.S., 1995. NEUROEXCITATORY ACTIONS OF CIGUATOXIN ON BRAIN-REGIONS ASSOCIATED WITH THERMOREGULATION. Neuroreport 6, 305-309.

Pennotti, R., Scallan, E., Backer, L., Thomas, J., Angulo, F.J., 2013. Ciguatera and Scombroid Fish Poisoning in the United States. Foodborne Pathogens and Disease 10, 1059-1066.

Perez, C.M., Vasquez, P.A., Perret, C.F., 2001. : Treatment of ciguatera poisoning with gabapentin. : New England Journal Of Medicine. Mar 344, 692-693.

Perez, M., Canoa, P., Gomez, G., Teijeira, M., Fall, Y., 2005. The methoxyallene approach to oxacycles, Part 2: Stereoselective synthesis of 2,3-disubstituted oxepanes. Synthesis-Stuttgart, 411-414.

Perez, S., Vale, C., Alonso, E., Alfonso, C., Rodriguez, P., Otero, P., Alfonso, A., Vale, P., Hirama, M., Vieytes, M.R., Botana, L.M., 2011. A Comparative Study of the Effect of Ciguatoxins on Voltage-Dependent Na+ and K+ Channels in Cerebellar Neurons. Chem. Res. Toxicol. 24, 587-596.

Perez-Guzman, L., Perez-Matos, A.E., Rosado, W., Tosteson, T.R., Govind, N.S., 2008. Bacteria associated with toxic clonal cultures of the dinoflagellate Ostreopsis lenticularis. Mar. Biotechnol. 10, 492-496.

Perkins, R.A., Morgan, S.S., 2004. Poisoning, envenomation, and trauma from marine creatures. American Family Physician 69, 885-890.

Pesando, D., Girard, J.P., Durandclement, M., Payan, P., Puiseuxdao, S., 1991. EFFECT OF MAITOTOXIN ON SEA-URCHIN EGG FERTILIZATION AND ON CA2+ PERMEABILITIES OF EGGS AND INTRACELLULAR STORES. Biology of the Cell 72, 269-273.

Pietra, F., 2008. Binding of ciguatera toxins to the voltage-gated Kv1.5 potassium channel in the open state. Docking of gambierol and molecular dynamics simulations of a homology model. J. Phys. Org. Chem. 21, 997-1001.

Pietra, F., 2009. COMPUTER SIMULATIONS OF THE INTERACTION OF CIGUATOXIN 3C, BREVENAL AND ent-BREVENAL LADDER POLYETHERS WITH A HOMOLOGY MODEL OF THE VOLTAGE-GATED Kv1.5 POTASSIUM CHANNEL. J. Theor. Comput. Chem. 8, 957-971.

Pignol, B., Auvin, S., Carre, D., Marin, J.G., Chabrier, P.E., 2006. Calpain inhibitors and antioxidants act synergistically to prevent cell necrosis: effects of the novel dual inhibitors (cysteine protease inhibitor and antioxidant) BN 82204 and its pro-drug BN 82270. J. Neurochem. 98, 1217-1228.

Pignol, B., Marin, J.G., Chabrier, P.E., 2002. Synergistic protection of calpain inhibitors and ROS scavengers against cell death induced by maitotoxin in cell cultures. Neuromuscular Disorders 12, 749-749.

Pin, J.P., Yasumoto, T., Bockaert, J., 1988. MAITOTOXIN-EVOKED GAMMA-AMINOBUTYRIC ACID RELEASE IS DUE NOT ONLY TO THE OPENING OF CALCIUM CHANNELS. J. Neurochem. 50, 1227-1232.

Pin, L.C., Teen, L.P., Ahmad, A., Usup, G., 2001. Genetic diversity of Ostreopsis ovata (Dinophyceae) from Malaysia. Mar. Biotechnol. 3, 246-255.

Place, A.R., Harvey, H.R., Bai, X., Coats, D.W., 2004. Sneaking under the toxin surveillance radar: parasitism and sterol content, 11th International Conference on Harmful Algae. Natl Inquiry Services Centre Pty Ltd, Cape Town, SOUTH AFRICA, pp. 347-351.

Place, A.R., Harvey, H.R., Bai, X., Coats, D.W., 2006. Sneaking under the toxin surveillance radar: parasitism and sterol content. Afr. J. Mar. Sci. 28, 347-351.

Pocsidio, G.N., Dimaano, L.M., 2004. The population densities of potentially toxic epiphytic dinoflagellates in Lingsat Reef, La Union Province, Philippines. Philippine Agricultural Scientist 87, 148-159.

Poli, M.A., Lewis, R.J., Dickey, R.W., Musser, S.M., Buckner, C.A., Carpenter, L.G., 1997. Identification of Caribbean ciguatoxins as the cause of an outbreak of fish poisoning among US soldiers in Haiti. Toxicon 35, 733-741.

Poli, M.A., Musser, S.M., Hall, S., 1997. Laboratory diagnostics of brevetoxin and ciguatoxin intoxications in humans: Case reports and sampling considerations, in: Seret, B., Sire, J.Y. (Eds.), 5th Indo-Pacific Fish Conference, Noumea, New Caledonia, pp. 775-781.

Pompon, A., Bagnis, R., 1984. CIGUATERA - A RAPID PROCEDURE FOR EXTRACTION OF CIGUATOXIN. Toxicon 22, 479-482.

Pompon, A., Chungue, E., Chazelet, I., Bagnis, R., 1984. CIGUATERA - A RAPID, SIMPLE AND DEPENDABLE METHOD FOR DETECTING CIGUATOXIN. Bulletin of the World Health Organization 62, 639-645.

Pottier, I., Hamilton, B., Jones, A., Lewis, R.J., Vernoux, J.P., 2003. Identitication of slow and fast-acting toxins in a highly ciguatoxic barracuda (Sphyraena barracuda) by HPLC/MS and radiolabelled ligand binding. Toxicon 42, 663-672.

Pottier, I., Vernoux, J.P., Jones, A., Lewis, R.J., 2002. Analysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West Indies. Food Addit. Contam. 19, 1034-1042.

Pottier, I., Vernoux, J.P., Jones, A., Lewis, R.J., 2002. Characterisation of multiple Caribbean ciguatoxins and congeners in individual specimens of horse-eye jack (Caranx latus) by high-performance liquid chromatography/mass spectrometry. Toxicon 40, 929-939.

Pottier, I., Vernoux, J.P., Lewis, R.J., 2001. Ciguatera fish poisoning in the Caribbean islands and western Atlantic, Reviews of Environmental Contamination and Toxicolgy, pp. 99-141.

Puente, S.P., Majada, A.C., Nunez, M.L., Solis, M.A., Gonzalez-Lahoz, J.M., 2005. Ciguatera: Eight imported cases. Revista Clinica Espanola 205, 47-50.

Puiseux, D.-S., Bouaicha, N., Diogene, G., 2000. : Maitotoxin, okadaic acid, and microcystins: Toxins that disturb signal transduction and phosphorylations. : Animal Toxins, 20-30.

Purcell, C.E., Capra, M.F., Cameron, J., 1999. Action of mannitol in ciguatoxin-intoxicated rats. Toxicon 37, 67-76.

Quod, J.P., 1994. OSTREOPSIS-MASCARENENSIS SP-NOV (DINOPHYCEAE), A NEW TOXIC DINOFLAGELLATE FROM CORAL-REEFS IN THE SOUTHWEST INDIAN-OCEAN. Cryptogam. Algol. 15, 243-251.

Quod, J.P., Bourdeau, P., Turquet, J., Guignard, A., 1994. CIGUATERA IN FRENCH OVERSEAS TERRITORIES - EPIDEMIOLOGIC AND PATHOPHYSIOLOGICAL ASPECTS. Recueil De Medecine Veterinaire 170, 141-146.

Quod, J.P., Legrand, A.M., 1988. EFFECTS OF PARTIALLY PURIFIED CIGUATOXIN FROM MORAY-EEL, GYMNOTHORAX-JAVANICUS, ON ACTION-POTENTIAL OF ISOLATED RAT-HEART. Toxicon 26, 36-37.

Quod, J.P., Turquet, J., 1996. Ciguatera in Réunion Island (SW Indian Ocean): Epidemiology and clinical patterns. Toxicon 34, 779-785.

Ragelis, E.P., 1983

1984. Ciguatera seafood poisoning: Overview, in: Ragelis, E.P. (Ed.), Seafood Toxins. American Chemical Society, Washington, D.C. (Proc. Symp. at 186th ACS Conf.), pp. 25-36.

Raikhlin-Eisenkraft, B., Bentur, Y., 2002. Rabbittish ("aras"): An unusual source of ciguatera poisoning. Israel Medical Association Journal 4, 28-30.

Rainier, J.D., Allwein, S.P., Cox, J.M., 2000. A highly efficient synthesis of the hemibrevetoxin B ring system. Org. Lett. 2, 231-234.

Ramialiharisoa, A., Rafenoherimanana, R., DeHaro, L., Jouglard, J., 1996. Ciguatera poisoning after eating shark in Madagascar - Data collected by the Antananarivo medical team. Presse Med. 25, 1350-1350.

Ravelo, J.L., Regueiro, A., Martin, J.D., 1992. NEW SYNTHETIC STRATEGY FOR THE CONSTRUCTION OF TRANSFUSED MEDIUM-SIZED CYCLIC ETHERS - SYNTHESIS OF THE IJK FRAMEWORK OF THE POLYETHER CIGUATOXIN. Tetrahedron Lett. 33, 3389-3392.

Ravelo, J.L., Regueiro, A., Rodriguez, E., deVera, J., Martin, J.D., 1996. Synthetic studies towards ciguatoxin via acetal/gamma-oxovinyl stannane condensation: A convergent approach. Tetrahedron Lett. 37, 2869-2872.

Reggelin, M., Gerlach, M., Vogt, M., 1999. Metallated 2-alkenyl sulfoximines in asymmetric synthesis: Regio- and stereoselective synthesis of highly substituted oxabicyclic ethers and studies towards the total syntheses of the euglobals G1 and G2 and arenaran A. Eur. J. Org. Chem., 1011-1031.

Reyes, J.G., Osses, N., Knox, M., Darszon, A., Trevino, C.L., 2010. Glucose and lactate regulate maitotoxin-activated Ca2+ entry in spermatogenic cells: The role of intracellular Ca2+. FEBS Lett. 584, 3111-3115.

Rho, M.C., Nakahata, N., Nakamura, H., Murai, A., Ohizumi, Y., 1995. ACTIVATION OF RABBIT PLATELETS BY CA2+ INFLUX AND THROMBOXANE A(2) RELEASE IN AN EXTERNAL CA2+-DEPENDENT MANNER BY ZOOXANTHELLATOXIN-A, A NOVEL POLYOL. Br. J. Pharmacol. 115, 433-440.

Rho, M.C., Park, Y.H., Sasaki, S., Ishibashi, M., Kondo, K., Kobayashi, J., Ohizumi, Y., 1996. The mode of rabbit platelet shape change and aggregation induced by theonezolide-A, a novel polyketide macrolide, isolated from the Okinawan marine sponge Theonella sp. Canadian Journal of Physiology and Pharmacology 74, 193-199.

Rhodes, L., Harwood, T., Smith, K., Argyle, P., Munday, R., 2014. Production of ciguatoxin and maitotoxin by strains of Gambierdiscus australes, G. pacificus and G. polynesiensis (Dinophyceae) isolated from Rarotonga, Cook Islands. Harmful Algae 39, 185-190.

Rhodes, L.L., Smith, K.F., Munday, R., Selwood, A.I., McNabb, P.S., Holland, P.T., Bottein, M.-Y., 2010. Toxic dinoflagellates (Dinophyceae) from Rarotonga, Cook Islands. Toxicon 56, 751-758.

Richardson, J.G., 1993. Field kit for detecting analytes. PCT Int. Appl., 17 pp.

Richlen, M.L., Lobel, P.S., 2011. Effects of depth, habitat, and water motion on the abundance and distribution of ciguatera dinoflagellates at Johnston Atoll, Pacific Ocean. Marine Ecology Progress Series 421, 51-66.

Richlen, M.L., Morton, S.L., Barber, P.H., Lobel, P.S., 2008. Phylogeography, morphological variation and taxonomy of the toxic dinoflagellate Gambierdiscus toxicus (Dinophyceae). Harmful Algae 7, 614-629.

Riobo, P., Franco, J.M., 2011. Palytoxins: Biological and chemical determination. Toxicon 57, 368-375.

Riobo, P., Paz, B., Franco, J.M., Vazquez, J.A., Murado, M.A., Cacho, E., 2008. Mouse bioassay for palytoxin. Specific symptoms and dose-response against dose-death time relationships. Food Chem. Toxicol. 46, 2639-2647.

Rizek, R., Tsushima, R.G., 2002. Selectivity and modulation of maitotoxin-activated channels in rat cardiac myocytes. Biophys. J. 82, 248A-248A.

Rizek, R., Tsushima, R.G., 2003. Regulation of maitotoxin-activated channels in rat cardiac myocytes. Biophys. J. 84, 424A-424A.

Robertson, A., Garcia, A., Quintana, H.A.F., Smith, T.B., II, B.C., Reale-Munroe, K., Gulli, J.A., Olsen, D.A., Hooe-Rollman, J.I., Jester, E.L.E., Klimek, B.J., Plakas, S.M., 2014. Invasive Lionfish (Pterois volitans): A Potential Human Health Threat for Ciguatera Fish Poisoning in Tropical Waters. Mar. Drugs 12, 88-97.

Robertson, A., Garcia, A.C., Flores Quintana, H.A., Smith, T.B., Castillo Ii, B.F., Reale-Munroe, K., Gulli, J.A., Olsen, D.A., Hooe-Rollman, J.I., Jester, E.L.E., Klimek, B.J., Plakas, S.M., 2014. Invasive lionfish (Pterois volitans): A potential human health threat for ciguatera fish poisoning in tropical waters. Mar. Drugs 12, 88-97.

Robertson, A., Garcia, A.C., Quintana, H.A., Smith, T.B., Castillo, B.F., 2nd, Reale-Munroe, K., Gulli, J.A., Olsen, D.A., Hooe-Rollman, J.I., Jester, E.L., Klimek, B.J., Plakas, S.M., 2014. Invasive lionfish (Pterois volitans): a potential human health threat for ciguatera fish poisoning in tropical waters. Mar Drugs 12, 88-97.

Robertson, A., Garcia, A.C., Quintana, H.A.F., Smith, T.B., Castillo, B.F., 2nd, Reale-Munroe, K., Gulli, J.A., Olsen, D.A., Hooe-Rollman, J.I., Jester, E.L.E., Klimek, B.J., Plakas, S.M., 2014. Invasive lionfish (Pterois volitans): a potential human health threat for ciguatera fish poisoning in tropical waters. Mar. Drugs 12, 88-97.

Robertson, R., 2003. The edible West Indian "whelk' Cittarium pica (Gastropoda : Trochidae): Natural history with new observations. Proc. Acad. Nat. Sci. Phila. 153, 27-47.

Robinson, R., de Ribes, G.C., Ranaivoson, G., Rejely, M., Rabeson, D., 1999. KAP (Knowledge, attitude and practice) study on seafood poisoning on the south western shore of Madagascar. Bulletin De La Societe De Pathologie Exotique 92, 46-50.

Röder, K., Erler, K., Kibler, S., Tester, P., Van The, H., Nguyen-Ngoc, L., Gerdts, G., Luckas, B., 2010. Characteristic profiles of Ciguatera toxins in different strains of Gambierdiscus spp. Toxicon 56, 731-738.

Rodriguez, N., Mass, H., Tosteson, T., Santiago, O., Castro, M., Feliciano, L., Montalvo, I., Deleon, N., Figueroa, M., 1992. CIGUATOXIN INDUCED MYOCARDIAL DYSFUNCTION. Faseb J. 6, A1582-A1582.

Roe, M.W., Worley, J.F., Qian, F., Tamarina, N., Mittal, A.A., Dralyuk, F., Blair, N.T., Mertz, R.J., Philipson, L.H., Dukes, I.D., 1998. Characterization of a Ca2+ release-activated nonselective cation current regulating membrane potential and Ca2+ (i) oscillations in transgenically derived beta-cells. J. Biol. Chem. 273, 10402-10410.

Roeder, K., Erler, K., Kibler, S., Tester, P., Van The, H., Nguyen-Ngoc, L., Gerdts, G., Luckas, B., 2010. Characteristic profiles of Ciguatera toxins in different strains of Gambierdiscus spp. Toxicon 56, 731-738.

Rongo, T., van Woesik, R., 2011. Ciguatera poisoning in Rarotonga, southern Cook Islands. Harmful Algae 10, 345-355.

Rongo, T., van Woesik, R., 2012. Socioeconomic consequences of ciguatera poisoning in Rarotonga, southern Cook Islands. Harmful Algae 20, 92-100.

Rossini, G.P., Hess, P., 2010. Phycotoxins: chemistry, mechanisms of action and shellfish poisoning, Exs, pp. 65-122.

Roué, M., Cruchet, P., Ung, A., Darius, T., Chinain, M., Laurent, D., 2013. Giant clams: New vectors of ciguatera? Toxicon 75, 206.

Roué, M., Darius, H.T., Picot, S., Ung, A., Viallon, J., Gaertner-Mazouni, N., Sibat, M., Amzil, Z., Chinain, M., 2016. Evidence of the bioaccumulation of ciguatoxins in giant clams (Tridacna maxima) exposed to Gambierdiscus spp. cells. Harmful Algae 57, Part A, 78-87.

Ruan, Q.M., Tucholski, J., Gundemir, S., Voll, G., 2008. The Differential Effects of R580A Mutation on Transamidation and GTP Binding Activity of Rat and Human Type 2 Transglutaminase. International Journal of Clinical and Experimental Medicine 1, 248-259.

Ruprecht, K., Rieckmann, P., Giess, R., 2001. Ciguatera: clinical relevance of a marine neurotoxine. Deutsche Medizinische Wochenschrift 126, 812-814.

Russell, F.E., Egen, N.B., 1991. CIGUATERIC FISHES, CIGUATOXIN (CTX) AND CIGUATERA POISONING. Journal of Toxicology-Toxin Reviews 10, 37-62.

Ryan, J.C., Dechraoui, M.Y.B., Morey, J.S., Rezvani, A., Levin, E.D., Gordon, C.J., Ramsdell, J.S., Van Dolah, F.M., 2007. Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1. Neurotoxicology 28, 1099-1109.

Ryan, J.C., Morey, J.S., Bottein, M.Y., Ramsdell, J.S., Van Dolah, F.M., 2010. Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response. BMC Neurosci 11, 107.

Ryan, J.C., Morey, J.S., Bottein, M.Y.D., Ramsdell, J.S., Van Dolah, F.M., 2010. Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response. BMC Neurosci. 11.

Ryan, J.C., Wu, Q., Shoemaker, R.C., 2015. Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin. BMC Med Genomics 8, 15.

Saeeng, R., Isobe, M., 1999. Partial synthesis of ciguatoxin (5R)-ABC segment. Tetrahedron Lett. 40, 1911-1914.

Saeeng, R., Isobe, M., 2001. Synthesis of ciguatoxin (2S,5R)-ABC segment. Heterocycles 54, 789-+.

Saeeng, R., Isobe, M., 2006. Stereoselective C-alkynylation, allenylation, and prop-2-ynylation leading to sugar glycosides. Chem. Lett. 35, 552-557.

Sakamoto, Y., Koshizuka, M., Koshino, H., Nakata, T., 2002. Rearrangement reaction of 2-methyltetrahydropyrans having a C1 '-mesyloxy group on the C2-side chain with zinc acetate: Ring expansion and ring opening reactions. Heterocycles 56, 113-117.

Sakamoto, Y., Matsuo, G., Matsukura, H., Nakata, T., 2001. Stereoselective syntheses of the C ' D ' E ' F '-ring system of maitotoxin and the FG-ring system of gambierol. Org. Lett. 3, 2749-2752.

Sakamoto, Y., Tamegai, K., Nakata, T., 2002. Stereoselective ring expansion via bicyclooxonium ion. A novel approach to oxocanes. Org. Lett. 4, 675-678.

Salzman, M., Madsen, J.M., Greenberg, M.I., 2006. Toxins: Bacterial and marine toxins. Clin. Lab. Med. 26, 397-+.

SanchezBueno, A., Yoshida, R., Tsuji, F.I., 1996. Regeneration and luminescence of aequorin in Chinese hamster ovary cells transformed with cDNA for apoaequorin. Int. J. Biochem. Cell Biol. 28, 1045-1049.

Sanner, B.M., Rawert, B., Henning, B., Zidek, W., 1997. Ciguatera fish poisoning following travel to the tropics. Zeitschrift Fur Gastroenterologie 35, 327-330.

Santostasi, G., Kutty, R.K., Bartorelli, A.L., Yasumoto, T., Krishna, G., 1990. MAITOTOXIN-INDUCED MYOCARDIAL-CELL INJURY - CALCIUM ACCUMULATION FOLLOWED BY ATP DEPLETION PRECEDES CELL-DEATH. Toxicol. Appl. Pharmacol. 102, 164-173.

Sasakawa, N., Nakaki, T., Kato, R., 1993. CHARACTERISTICS OF INOSITOL POLYPHOSPHATE METABOLISM IN CULTURED ADRENAL CHROMAFFIN CELLS. Progress in Neuro-Psychopharmacology & Biological Psychiatry 17, 825-834.

Sasaki, M., 2007. Development and application of a convergent strategy for the total synthesis of polycyclic ether natural products. Bull. Chem. Soc. Jpn. 80, 856-871.

Sasaki, M., Ebine, M., Takagi, H., Takakura, H., Shida, T., Satake, M., Oshima, Y., Igarashi, T., Yasumoto, T., 2004. Synthesis of the CDE/FG ring models of prymnesins: Reassignment of the relative configuration of the E/F ring juncture. Org. Lett. 6, 1501-1504.

Sasaki, M., Fuwa, H., 2004. Total synthesis of polycyclic ether natural products based on Suzuki-Miyaura cross-coupling. Synlett, 1851-1874.

Sasaki, M., Fuwa, H., 2008. Convergent strategies for the total synthesis of polycyclic ether marine metabolites. Nat. Prod. Rep. 25, 401-426.

Sasaki, M., Fuwa, H., Inoue, M., Tachibana, K., 1998. New strategy for convergent synthesis of trans-fused polyether frameworks based on palladium-catalyzed Suzuki cross-coupling reaction. Tetrahedron Lett. 39, 9027-9030.

Sasaki, M., Fuwa, H., Ishikawa, M., Tachibana, K., 1999. A general method for convergent synthesis of polycyclic ethers based on Suzuki cross-coupling: Concise synthesis of the ABCD ring system of ciguatoxin. Org. Lett. 1, 1075-1077.

Sasaki, M., Hasegawa, A., Tachibana, K., 1993. STEREOSELECTIVE SYNTHESIS OF A KLM RING MODEL OF CIGUATOXIN - CONFIRMATION OF THE C54 STEREOCHEMISTRY. Tetrahedron Lett. 34, 8489-8492.

Sasaki, M., Inoue, M., 2001. Synthetic studies on polyether natural products: New synthetic methods for construction of medium-sized cyclic ethers and convergent coupling of polyether fragments. J. Synth. Org. Chem. Jpn. 59, 193-205.

Sasaki, M., Inoue, M., Tachibana, K., 1994. SYNTHETIC STUDIES TOWARD CIGUATOXIN - STEREOCONTROLLED CONSTRUCTION OF THE KLM RING FRAGMENT. J. Org. Chem. 59, 715-717.

Sasaki, M., Inoue, M., Takamatsu, K., Tachibana, K., 1999. Stereocontrolled synthesis of the JKLM ring fragment of ciguatoxin. J. Org. Chem. 64, 9399-9415.

Sasaki, M., Ishikawa, M., Fuwa, H., Tachibana, K., 2002. A general strategy for the convergent synthesis of fused polycyclic ethers via B-alkyl Suzuki coupling: synthesis of the ABCD ring fragment of ciguatoxins. Tetrahedron 58, 1889-1911.

Sasaki, M., Matsumori, N., Maruyama, T., Nonomura, T., Murata, M., Tachibana, K., Yasumoto, T., 1996. The complete structure of maitotoxin .1. Configuration of the C1-C14 side chain. Angewandte Chemie-International Edition in English 35, 1672-&.

Sasaki, M., Matsumori, N., Murata, M., Tachibana, K., Yasumoto, T., 1995. STEREOCHEMICAL ASSIGNMENT OF THE C35-C39 ACYCLIC LINKAGE IN MAITOTOXIN - COMPLETION OF STEREOCHEMICAL DETERMINATION OF C15-C134. Tetrahedron Lett. 36, 9011-9014.

Sasaki, M., Murata, M., 1997. Complete structure of maitotoxin. J. Synth. Org. Chem. Jpn. 55, 535-546.

Sasaki, M., Noguchi, K., Fuwa, H., Tachibana, K., 2000. Convergent synthesis of an HIJK ring model of ciguatoxin via Suzuki cross-coupling reaction. Tetrahedron Lett. 41, 1425-1428.

Sasaki, M., Noguchi, T., Tachibana, K., 1999. Synthesis of the FGH ring fragment of ciguatoxin. Tetrahedron Lett. 40, 1337-1340.

Sasaki, M., Noguchi, T., Tachibana, K., 2002. Intramolecular radical cyclization - Ring-closing metathesis approach to fused polycyclic ethers. Convergent synthesis and conformational analysis of the (E)FGH ring system of ciguatoxin. J. Org. Chem. 67, 3301-3310.

Sasaki, M., Nonomura, T., Murata, M., Tachibana, K., 1994. SYNTHESIS AND STEREOCHEMICAL CONFIRMATION OF THE CIS-FUSED L/M AND N/O RING-SYSTEMS OF MAITOTOXIN. Tetrahedron Lett. 35, 5023-5026.

Sasaki, M., Nonomura, T., Murata, M., Tachibana, K., 1995. SYNTHETIC APPROACH TOWARD COMPLETE STRUCTURE DETERMINATION OF MAITOTOXIN - STEREOCHEMICAL ASSIGNMENT OF THE C63-C68 ACYCLIC LINKAGE. Tetrahedron Lett. 36, 9007-9010.

Sasaki, M., Shida, T., Tachibana, K., 2001. Synthesis and stereochemical confirmation of the HI/JK ring system of prymnesins, potent hemolytic and ichthyotoxic glycoside toxins isolated from the red tide alga. Tetrahedron Lett. 42, 5725-5728.

Sasaki, M., Takeda, N., Fuwa, H., Watanabe, R., Satake, M., Oshima, Y., 2006. Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture. Tetrahedron Lett. 47, 5687-5691.

Satake, M., Campbell, A., Van Wagoner, R.M., Bourdelais, A.J., Jacocks, H., Baden, D.G., Wright, J.L.C., 2009. Brevisin: An Aberrant Polycyclic Ether Structure from the Dinoflagellate Karenia brevis and Its Implications for Polyether Assembly. J. Org. Chem. 74, 989-994.

Satake, M., Fukui, M., Legrand, A.M., Cruchet, P., Yasumoto, T., 1998. Isolation and structures of new ciguatoxin analogs, 2,3-dihydroxyCTX3C and 51-hydroxyCTX3C, accumulated in tropical reef fish. Tetrahedron Lett. 39, 1197-1198.

Satake, M., Ishibashi, Y., Legrand, A.M., Yasumoto, T., 1996. Isolation and structure of ciguatoxin-4A, a new ciguatoxin precursor, from cultures of dinoflagellate Gambierdiscus toxicus and parrotfish Scarus gibbus. Biosci. Biotechnol. Biochem. 60, 2103-2105.

Satake, M., Ishida, S., Yasumoto, T., Murata, M., Utsumi, H., Hinomoto, T., 1995. STRUCTURAL CONFIRMATION OF MAITOTOXIN BASED ON COMPLETE C-13 NMR ASSIGNMENTS AND THE 3-DIMENSIONAL PFG NOESY-HMQC SPECTRUM. J. Am. Chem. Soc. 117, 7019-7020.

Satake, M., Morohashi, A., Oguri, H., Oishi, T., Hirama, M., Harada, N., Yasumoto, T., 1997. The absolute configuration of ciguatoxin. J. Am. Chem. Soc. 119, 11325-11326.

Satake, M., Murata, M., Yasumoto, T., 1993. The structure of CTX3C, a ciguatoxin congener isolated from cultured Gambierdiscus toxicus. Tetrahedron Lett. 34, 1975-1978.

Satake, M., Shoji, M., Oshima, Y., Naoki, H., Fujita, T., Yasumoto, T., 2002. Gymnocin-A, a cytotoxic polyether from the notorious red tide dinoflagellate, Gymnodinium mikimotoi. Tetrahedron Lett. 43, 5829-5832.

Sato, M., 1997. Total synthesis of marine derived natural toxin, ''brevetoxin B''. J. Synth. Org. Chem. Jpn. 55, 686-696.

Sato, O., Hirama, M., 1992. SYNTHESIS OF THE AB RING FRAGMENT OF CIGUATOXIN - LIGAND CONTROLLED REGIOSELECTIVE ADDITION OF OSMIUM-TETROXIDE TO DOUBLE-BONDS. Synlett, 705-707.

Satoh, E., Ishii, T., Nishimura, M., 2001. The mechanism of maitotoxin-induced elevation of the cytosolic free calcium level in rat cerebrocortical synaptosomes. Japanese Journal of Pharmacology 85, 98-100.

Satoh, M., Koshino, H., Nakata, T., 2008. Synthetic studies on maitotoxin. 3. Stereloselective synthesis of the BCDE-ring system. Org. Lett. 10, 1683-1685.

Satoh, M., Mori, M., Nakata, T., 2007. Stereoselective synthesis of the GHI-ring of maitotoxin, a marine polycyclic ether. Heterocycles 74, 259-263.

Sauviat, M.P., Garrec, R.B.L., Masson, J.B., Lewis, R.L., Vernoux, J.P., Molgo, J., Laurent, D., Benoit, E., 2006. Mechanisms involved in the swelling of erythrocytes caused by Pacific and Caribbean ciguatoxins. Blood Cells Molecules and Diseases 36, 1-9.

Sauviat, M.P., Marquais, M., Vernoux, J.P., 2002. Muscarinic effects of the Caribbean ciguatoxin C-CTX-1 on frog atrial heart muscle. Toxicon 40, 1155-1163.

Sberna, G., SaezValero, J., Beyreuther, K., Masters, C.L., Small, D.H., 1997. The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells. J. Neurochem. 69, 1177-1184.

Schettini, G., Koike, K., Login, I.S., Judd, A.M., Cronin, M.J., Yasumoto, T., Macleod, R.M., 1984. MAITOTOXIN STIMULATES HORMONAL RELEASE AND CALCIUM FLUX IN RAT ANTERIOR-PITUITARY CELLS-INVITRO. American Journal of Physiology 247, E520-E525.

Schettini, G., Meucci, O., Grimaldi, M., Florio, T., Landolfi, E., Scorziello, A., Ventra, C., 1991. DIHYDROPYRIDINE MODULATION OF VOLTAGE-ACTIVATED CALCIUM CHANNELS IN PC12 CELLS - EFFECT OF PERTUSSIS TOXIN PRETREATMENT. J. Neurochem. 56, 805-811.

Scheuer, P.J., 1994. CIGUATERA AND ITS OFF-SHOOTS - CHANCE ENCOUNTERS EN-ROUTE TO A MOLECULAR-STRUCTURE. Tetrahedron 50, 3-18.

Scheuer, P.J., 1996. Marine toxin research - An historical overview. Journal of Natural Toxins 5, 181-189.

Scheuer, P.J., Takahashi, W., Tsutsumi, J., Yoshida, T., 1967. Ciguatera: Isolation and chemical nature. Science [Science] 155, 1267-1268.

Schilling, W.P., Sinkins, W.G., 1998. Maitotoxin (MTX) activates a P2Z/P2X7-like cytolytic pathway in human skin fibroblasts. Faseb J. 12, A1021-A1021.

Schilling, W.P., Sinkins, W.G., Estacion, M., 1999. Maitotoxin activates a nonselective cation channel and a P2Z/P2X(7)-like cytolytic pore in human skin fibroblasts. Am. J. Physiol.-Cell Physiol. 277, C755-C765.

Schilling, W.P., Snyder, D., Sinkins, W.G., Estacion, M., 2006. Palytoxin-induced cell death cascade in bovine aortic endothelial cells. Am. J. Physiol.-Cell Physiol. 291, C657-C667.

Schilling, W.P., Wasylyna, T., Dubyak, G.R., Humphreys, B.D., Sinkins, W.G., 1999. Maitotoxin and P2Z/P2X(7) purinergic receptor stimulation activate a common cytolytic pore. Am. J. Physiol.-Cell Physiol. 277, C766-C776.

Schlaich, C., Hagelstein, J.-G., Burchard, G.-D., Schmiedel, S., 2012. Outbreak of Ciguatera Fish Poisoning on a Cargo Ship in the Port of Hamburg. Journal of Travel Medicine 19, 238-242.

Schlumberger, S., Mattei, C., Molgo, J., Benoit, E., 2010. Dual action of a dinoflagellate-derived precursor of Pacific ciguatoxins (P-CTX-4B) on voltage-dependent K(+) and Na(+) channels of single myelinated axons. Toxicon 56, 768-775.

Schlumberger, S., Mattei, C., Molgó, J., Benoit, E., 2010. Dual action of a dinoflagellate-derived precursor of Pacific ciguatoxins (P-CTX-4B) on voltage-dependent K+ and Na+ channels of single myelinated axons. Toxicon 56, 768-775.

Schlumberger, S., Ouanounou, G., Girard, E., Sasaki, M., Fuwa, H., Louzao, M.C., Botana, L.M., Benoit, E., Molgó, J., 2010. The marine polyether gambierol enhances muscle contraction and blocks a transient K+ current in skeletal muscle cells. Toxicon 56, 785-791.

Schulick, A., Gusovsky, F., Yasumoto, T., Daly, J.W., 1990. EFFECTS OF MAITOTOXIN ON ATRIAL NATRIURETIC FACTOR-MEDIATED ACCUMULATION OF CYCLIC-GMP IN PC12 CELLS. Life Sci. 46, 671-678.

Scoging, A.C., 1998. Marine biotoxins. J. Appl. Microbiol. 84, 41S-50S.

Seino, A., Kobayashi, M., Momose, K., Yasumoto, T., Ohizumi, Y., 1988. THE MODE OF INOTROPIC ACTION OF CIGUATOXIN ON GUINEA-PIG CARDIAC-MUSCLE. Br. J. Pharmacol. 95, 876-882.

Seino, A., Momose, K., Yasumoto, T., Kobayashi, M., Ohizumi, Y., 1987. THE MODE OF CARDIOTONIC ACTION OF CIGUATOXIN ON ATRIAL MUSCLE. Japanese Journal of Pharmacology 43, P173-P173.

Selina, M.S., Levchenko, E.V., 2011. Species Composition and Morphology of Dinoflagellates (Dinophyta) of Epiphytic Assemblages of Peter the Great Bay in the Sea of Japan. Russ. J. Mar. Biol. 37, 23-32.

Senecal, P.E., Osterloh, J.D., 1991. NORMAL FETAL-OUTCOME AFTER MATERNAL CIGUATERIC TOXIN EXPOSURE IN THE 2ND TRIMESTER. Journal of Toxicology-Clinical Toxicology 29, 473-478.

Senthilkumaran, S., Meenakshisundaram, R., Michaels, A.D., Suresh, P., Thirumalaikolundusubramanian, P., 2011. Cardiovascular Complications in Ciguatera Fish Poisoning: A Wake-up Call. Heart Views 12, 166-168.

Sewell, J.M., Mayer, I., Langdon, S.P., Smyth, J.F., Jodrell, D.I., Guichard, S.M., 2005. The mechanism of action of Kahalalide F: Variable cell permeability in human hepatoma cell lines. European Journal of Cancer 41, 1637-1644.

Shalaby, I.A., Kongsamut, S., Miller, R.J., 1986. MAITOTOXIN-INDUCED RELEASE OF GAMMA- H-3 AMINOBUTYRIC ACID FROM CULTURES OF STRIATAL NEURONS. J. Neurochem. 46, 1161-1165.

Shimizu, Y., Shimizu, H., Scheuer, P.J., Hokama, Y., Oyama, M., Miyahara, J.T., 1982. GAMBIERDISCUS-TOXICUS, A CIGUATERA-CAUSING DINOFLAGELLATE FROM HAWAII. Bulletin of the Japanese Society of Scientific Fisheries 48, 811-813.

Shimojo, R.Y., Iwaoka, W.T., 2000. A rapid hemolysis assay for the detection of sodium channel-specific marine toxins. Toxicology 154, 1-7.

Shing, T.K.M., Zhong, Y.L., 2006. Syntheses of medium-sized cyclic ethers from carbohydrates via an intramolecular nitrile oxide-alkene cycloaddition strategy. Synlett, 1205-1208.

Shirai, J.L., Shirai, L.K., Hokama, Y., 1991. Seafood poisoning: Ciguatera. Yosh Hokama Family Trust, Gardena, CA.

Shirai, L.K., Miyahara, J.T., Ching, N.P., Hokama, Y., 1986. EFFECT OF LOW DALTON AURICULARIA POLYTRICHA EXTRACT AND IONOPHORES ON THE INOTROPIC RESPONSE OF CIGUATOXIN (CTX) IN GUINEA-PIG ATRIA INVITRO. Federation Proceedings 45, 812-812.

Shoemaker, R.C., House, D., Ryan, J.C., 2010. Defining the neurotoxin derived illness chronic ciguatera using markers of chronic systemic inflammatory disturbances: A case/control study. Neurotoxicol. Teratol. 32, 633-639.

Sierra-Beltran, A.P., Cruz, A., Nunez, E., Del Villar, L.M., Cerecero, J., Ochoa, J.L., 1997. An overview of the marine food poisoning in Mexico, 12th World Congress on Animal, Plant and Microbial Toxins, Cuernavaca, Mexico, pp. 1493-1502.

Singh, V., Sarang, P., Bhalerao, P., Mobin, S.M., 2011. Oxocarbenium Ion Mediated Alkylation and Ring-Closing Metathesis: A General Iterative Approach towards Synthesis of Linearly Fused cis:anti:cis Polycyclic Ethers. Synlett, 386-390.

Sinkins, W.G., Estacion, M., Prasad, V., Goel, M., Shull, G.E., Kunze, D.L., Schilling, W.P., 2009. Maitotoxin converts the plasmalemmal Ca2+ pump into a Ca2+-permeable nonselective cation channel. Am. J. Physiol.-Cell Physiol. 297, C1533-C1543.

Skinner, M.P., Brewer, T.D., Johnstone, R., Fleming, L.E., Lewis, R.J., 2011. Ciguatera Fish Poisoning in the Pacific Islands (1998 to 2008). PLoS Negl Trop Dis 5, e1416.

Sladeczek, F., Schmidt, B.H., Alonso, R., Vian, L., Tep, A., Yasumoto, T., Cory, R.N., Bockaert, J., 1988. NEW INSIGHTS INTO MAITOTOXIN ACTION. European Journal of Biochemistry 174, 663-670.

Slobbe, L., van Genderen, P.J.J., Wismans, P.J., 2008. Two patients with ciguatera toxicity: a seafood poisoning in travellers to (sub) tropical areas. Neth. J. Med. 66, 389-391.

Soergel, D.G., Gusovsky, F., Yasumoto, T., Daly, J.W., 1990. STIMULATORY EFFECTS OF MAITOTOXIN ON INSULIN RELEASE IN INSULINOMA HIT CELLS - ROLE OF CALCIUM-UPTAKE AND PHOSPHOINOSITIDE BREAKDOWN. J. Pharmacol. Exp. Ther. 255, 1360-1365.

Soergel, D.G., Yasumoto, T., Daly, J.W., Gusovsky, F., 1992. MAITOTOXIN EFFECTS ARE BLOCKED BY SK-AND-F-96365, AN INHIBITOR OF RECEPTOR-MEDIATED CALCIUM ENTRY. Mol. Pharmacol. 41, 487-493.

Solino, L., Widgy, S., Pautonnier, A., Turquet, J., Loeffler, C.R., Flores Quintana, H.A., Diogene, J., 2015. Prevalence of ciguatoxins in lionfish (Pterois spp.) from Guadeloupe, Saint Martin, and Saint Barthelmy Islands (Caribbean). Toxicon : official journal of the International Society on Toxinology 102, 62-68.

Sorrentino, G., Monsurro, M.R., Singh, I.N., Kanfer, J.N., 1997. Membrane depolarization in LA-N-1 cells - The effect of maitotoxin is Ca2+- and Na+-dependent. Molecular and Chemical Neuropathology 30, 199-211.

Sortino, M.A., Delahunty, T.M., Yasumoto, T., Cronin, M.J., 1991. MAITOTOXIN INCREASES INOSITOL PHOSPHATES IN RAT ANTERIOR-PITUITARY-CELLS. J. Mol. Endocrinol. 6, 95-99.

Sozzi, G., Marotta, P., Aldeghi, D., Tredici, G., Calvi, L., 1988. POLYNEUROPATHY SECONDARY TO CIGUATOXIN POISONING. Italian Journal of Neurological Sciences 9, 491-495.

Sperry, J., Liu, Y.C., Brimble, M.A., 2010. Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction. Organic and Biomolecular Chemistry 8, 29-38.

Spoonster, J.R., Masiero, L., Savage, S.A., Probst, J., Kohn, E.C., 1997. Regulation of cell spreading during differentiation in the muscarinic M5 receptor tumor-suppressor model. Int. J. Cancer 72, 362-368.

Stephen Clark, J., Trevitt, G.P., Boyall, D., Stammen, B., 1998. Synthesis of alkenyl-substituted cyclic enol ethers by catalytic ring-closing metathesis of alkynyl ethers. Chem. Commun. (Cambridge), 2629-2630.

Stewart, I., Eaglesham, G.K., Poole, S., Graham, G., Paulo, C., Wickramasinghe, W., Sadler, R., Shaw, G.R., 2010. Establishing a public health analytical service based on chemical methods for detecting and quantifying Pacific ciguatoxin in fish samples. Toxicon 56, 804-812.

Stewart, I., Lewis, R.J., Eaglesham, G.K., Graham, G.C., Poole, S., Craig, S.B., 2010. Emerging tropical diseases in Australia. Part 2. Ciguatera fish poisoning. Ann Trop Med Parasitol 104, 557-571.

Stommel, E.W., Parsonnet, J., Jenkyn, L.R., 1991. POLYMYOSITIS AFTER CIGUATERA TOXIN EXPOSURE. Archives of Neurology 48, 874-877.

Strachan, L.C., Lewis, R.J., Nicholson, G.M., 1999. Differential actions of Pacific ciguatoxin-1 on sodium channel subtypes in mammalian sensory neurons. J. Pharmacol. Exp. Ther. 288, 379-388.

Sugg, L., VanDolah, F., 1999. No evidence for an allelopathic role of okadaic acid among ciguatera-associated dinoflagellates. J. Phycol. 35, 93-103.

Sugg, L.M., Vandolah, F.M., 1999. No evidence for an allelopathic role of okadaic acid among ciguatera-associated dinoflagellates. J. Phycol. 35, 93-103.

Sugg, L.M., VanDolan, M., 1999. No evidence for an allelopathic role of okadaic acid among ciguatera-associated dinoflagellates. J. Phycol. 35, 93-103.

Sumner, J., Ross, T., 2002. A semi-quantitative seafood safety risk assessment. Int. J. Food Microbiol. 77, 55-59.

Sunami, A., Glasser, I.W., Fozzard, H.A., 2001. Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics. Mol. Pharmacol. 59, 684-691.

Suzuki, T., Sato, O., Hirama, M., Yamamoto, Y., Murata, M., Yasumoto, T., Harada, N., 1991. Enantioselective synthesis of the AB ring fragment of gambiertoxin 4B. Implication for the absolute configuration of gambiertoxin 4B and ciguatoxin. Tetrahedron Letters [Tetrahedron Lett.] 32, 4505-4508.

Suzuki, T., Sato, O., Hirama, M., Yamamoto, Y., Murata, M., Yasumoto, T., Harada, N., 1991. ENANTIOSELECTIVE SYNTHESIS OF THE AB-RING FRAGMENT OF GAMBIERTOXIN-4B - IMPLICATION FOR THE ABSOLUTE-CONFIGURATION OF GAMBIERTOXIN-4B AND CIGUATOXIN. Tetrahedron Lett. 32, 4505-4508.

Swift, A.E.B., Swift, T.R., 1993. CIGUATERA. Journal of Toxicology-Clinical Toxicology 31, 1-29.

T., Y., M., M., J-S., L., K., T., 1988. Polyether toxins produced by dinoflagellates. Mycotoxins and Phycotoxins, 375-382.

Tachibana, K., Nukina, M., Joh, Y., Scheuer, P.J., 1987. Recent developments in the molecular structure of ciguatoxin. Biol. Bull. 172, 122-127.

Tachibana, K., Nukina, M., Joh, Y.G., Scheuer, P.J., 1987. RECENT DEVELOPMENTS IN THE MOLECULAR-STRUCTURE OF CIGUATOXIN. Biol. Bull. 172, 122-127.

Taglialatela, M., Amoroso, S., Yasumoto, T., Direnzo, G., Annunziato, L., 1986. MAITOTOXIN AND BAY-K-8644 - 2 PUTATIVE CALCIUM-CHANNEL ACTIVATORS WITH DIFFERENT EFFECTS ON ENDOGENOUS DOPAMINE RELEASE FROM TUBEROINFUNDIBULAR NEURONS. Brain Res. 381, 356-358.

Taglialatela, M., Canzoniero, L.M.T., Fatatis, A., Direnzo, G., Yasumoto, T., Annunziato, L., 1990. EFFECT OF MAITOTOXIN ON CYTOSOLIC CA-2+ LEVELS AND MEMBRANE-POTENTIAL IN PURIFIED RAT-BRAIN SYNAPTOSOMES. Biochimica Et Biophysica Acta 1026, 126-132.

Takahashi, M., Kondo, S., Ohizumi, Y., 1984. CA-2+-DEPENDENT MORPHOLOGICAL-CHANGES IN THE CELLULAR AND SUBCELLULAR STRUCTURES OF CLONAL NEURONAL CELLS INDUCED BY MAITOTOXIN. Neurochemical Research 9, 1130-1131.

Takahashi, M., Ohizumi, Y., Yasumoto, T., 1982. MAITOTOXIN, A CA-2+ CHANNEL ACTIVATOR CANDIDATE. J. Biol. Chem. 257, 7287-7289.

Takahashi, M., Ohizumi, Y., Yasumoto, T., 1983. EFFECTS OF MAITOTOXIN ON THE CALCIUM CHANNELS. Neurochemical Research 8, 784-784.

Takahashi, M., Tatsumi, M., Ohizumi, Y., Yasumoto, T., 1983. CA-2+ CHANNEL ACTIVATING FUNCTION OF MAITOTOXIN, THE MOST POTENT MARINE TOXIN KNOWN, IN CLONAL RAT PHEOCHROMOCYTOMA CELLS. J. Biol. Chem. 258, 944-949.

Takahashi, S., Fujisawa, K., Sakairi, N., Nakata, T., 2000. Stereoselective synthesis of the 3-hydroxy-tetrahydropyran part of mucocin, an antitumor agent, based on rearrangement-ring expansion reaction of a tetrahydrofuran derivative. Heterocycles 53, 1361-1370.

Takahashi, S., Hirota, S., Nakata, T., 2000. A novel synthesis of a 2,8-dioxabicyclo 3.2.1 octane skeleton from a 2,5-dialkyltetrahydrofuran derivative. Heterocycles 52, 1079-+.

Takai, S., Sawada, N., Isobe, M., 2003. Convergent synthesis of the E ' FGH ring fragment of ciguatoxin 1B via an acetylene cobalt complex strategy. J. Org. Chem. 68, 3225-3231.

Takai, S.Y., Isobe, M., 2002. Convergent synthesis of the E ' FGH ' ring fragment of ciguatoxin 1B via an acetylene cobalt complex strategy. Org. Lett. 4, 1183-1186.

Takakura, H., Noguchi, K., Sasaki, M., Tachibana, K., 2001. Synthetic studies on ciguatoxin: A highly convergent synthesis of the GHIJKLM ring system based on B-alkyl Suzuki coupling. Angew. Chem.-Int. Edit. 40, 1090-+.

Takakura, H., Sasaki, M., Honda, S., Tachibana, K., 2002. Progress toward the total synthesis of ciguatoxins: A convergent synthesis of the FGHIJKLM ring fragment. Org. Lett. 4, 2771-2774.

Takamura, H., 2006. Synthetic studies of marine polycyclic ether, ciguatoxins. J. Synth. Org. Chem. Jpn. 64, 418-419.

Takemura, A., Fujiwara, K., Murai, A., Kawai, H., Suzuki, T., 2004. Novel branched ether formation via conjugate reduction of an unsaturated cyanohydrin derivative and its synthetic application to the EF-ring segment of ciguatoxin. Tetrahedron Lett. 45, 7567-7571.

Takemura, A., Fujiwara, K., Shimawaki, K., Murai, A., Kawai, H., Suzuki, T., 2005. Synthesis of the EF-ring segment of ciguatoxin CTXIB based on novel regioselective reduction of unsaturated cyanohydrins and ring-closing olefin metathesis. Tetrahedron 61, 7392-7419.

Takizawa, A., Fujiwara, K., Doi, E., Murai, A., Kawai, H., Suzuki, T., 2006. Convergent synthesis of the common FGHI-ring part of ciguatoxins. Tetrahedron 62, 7408-7435.

Takizawa, A., Fujiwara, K., Doi, E., Murai, A., Kawai, H., Suzuki, T., 2006. Synthesis of the common FGHI-ring part of ciguatoxins. Tetrahedron Lett. 47, 747-751.

Tanaka, H., Kawai, K., Fujiwara, K., Murai, A., 2002. Synthesis of the AB-ring segment for the convergent construction of the left half in ciguatoxin. Tetrahedron 58, 10017-10031.

Tanaka, I., Matsuoka, S., Murata, M., Tachibana, K., 1998. A new ceramide with a novel branched-chain fatty acid isolated from the epiphytic dinoflagellate Coolia monotis. J. Nat. Prod. 61, 685-688.

Tanaka, S., Tatsuta, N., Yamashita, O., Isobe, M., 1994. RING-OPENING OF ALKYNYL SUGARS BY NICHOLAS REACTION - APPLICATION TO ENANTIOSELECTIVE SYNTHESIS OF OXEPANE SUBUNITS OF MARINE TRANS-FUSED POLYETHER TOXINS. Tetrahedron 50, 12883-12894.

Taniyama, S., 2008. The occurrence of palytoxin-like poisoning and ciguatera in parts of the main land of Japan. Nippon Suisan Gakkaishi 74, 917-918.

Tatami, A., Inoue, M., Uehara, H., Hirama, M., 2003. A concise route to the right wing of ciguatoxin. Tetrahedron Lett. 44, 5229-5233.

Taylor, F.J.R., Hoppenrath, M., Saldarriaga, J.F., 2008. Dinoflagellate diversity and distribution. Biodivers. Conserv. 17, 407-418.

Terao, K., Ito, E., Kakinuma, Y., Igarashi, K., Kobayashi, M., Ohizumi, Y., Yasumoto, T., 1989. HISTOPATHOLOGICAL STUDIES ON EXPERIMENTAL MARINE TOXIN POISONING .4. PATHOGENESIS OF EXPERIMENTAL MAITOTOXIN POISONING. Toxicon 27, 979-988.

Terao, K., Ito, E., Oarada, M., Ishibashi, Y., Legrand, A.M., Yasumoto, T., 1991. LIGHT AND ELECTRON-MICROSCOPIC STUDIES OF PATHOLOGICAL-CHANGES INDUCED IN MICE BY CIGUATOXIN POISONING. Toxicon 29, 633-643.

Terao, K., Ito, E., Sakamaki, Y., Igarashi, K., Yokoyama, A., Yasumoto, T., 1988. HISTOPATHOLOGICAL STUDIES OF EXPERIMENTAL MARINE TOXIN POISONING .2. THE ACUTE EFFECTS OF MAITOTOXIN ON THE STOMACH, HEART AND LYMPHOID-TISSUES IN MICE AND RATS. Toxicon 26, 395-402.

Terao, K., Ito, E., Yasumoto, T., 1992. Light and electron microscopic studies of the murine heart after repeated administrations of ciguatoxin or ciguatoxin-4C. Nat. Toxins 1, 19-26.

Terao, K., Ito, E., Yasumoto, T., Yamaguchi, K., 1990. : Enterotoxic, hepatotoxic and immunotoxic effects of dinoflagellate toxins on mice. : TOXIC MARINE PHYTOPLANKTON. Graneli, E., 418-423.

Tester, P.A., Feldman, R.L., Nau, A.W., Kibler, S.R., Litaker, R.W., 2010. Ciguatera fish poisoning and sea surface temperatures in the Caribbean Sea and the West Indies. Toxicon 56, 698-710.

Tester, P.A., Feldman, R.L., Nau, A.W., Kibler, S.R., Wayne Litaker, R., 2010. Ciguatera fish poisoning and sea surface temperatures in the Caribbean Sea and the West Indies. Toxicon 56, 698-710.

Tester, P.A., Vandersea, M.W., Buckel, C.A., Kibler, S.R., Holland, W.C., Davenport, E.D., Clark, R.D., Edwards, K.F., Taylor, J.C., Pluym, J.L.V., Hickerson, E.L., Litaker, R.W., 2013. Gambierdiscus (Dinophyceae) species diversity in the Flower Garden Banks National Marine Sanctuary, Northern Gulf of Mexico, USA. Harmful Algae 29, 1-9.

Tindall, D.R., Dickey, R.W., Carlson, R.D., Morey-Gaines, G., 1983

1984. Ciguatoxigenic dinoflagellates from the Caribbean Sea, in: Ragelis, E.P. (Ed.), Seafood Toxins (Am. Chem. Soc. Symp. Ser. No. 262). American Chemical Society, Washington, DC, pp. 225-240.

Tindall, D.R., Dickey, R.W., Carlson, R.D., Morey-Gaines, G., 1984. Ciguatoxigenic dinoflagellates from the Caribbean Sea, in: Ragelis, E.P. (Ed.), Seafood Toxins (Am. Chem. Soc. Symp. Ser. No. 262). American Chemical Society, Washington, DC, pp. 225-240.

Tindall, D.R., Miller, D.M., 1987. PURIFICATION AND ASSAY OF 2 CIGUATERA TOXINS FROM THE DINOFLAGELLATE PROROCENTRUM-CONCAVUM. Toxicon 25, 155-155.

Tindall, D.R., Miller, D.M., 1988. 2 POTENT TOXINS FROM OSTREOPSIS-LENTICULARIS, A DINOFLAGELLATE COMMON TO CIGUATERA-ENDEMIC REGIONS OF THE CARIBBEAN AND TROPICAL ATLANTIC. Faseb J. 2, A375-A375.

Tindall, D.R., Miller, D.M., Bomber, J.W., 1989. Culture and toxicity of dinoflagellates from ciguatera endemic regions of the world. Toxicon 27, 83.

Todd, Ec, Lipp, Ek, Rose, Jb, Williams, Ra, Zorn, Dj, Lucas, Re, Lewis, Rj, Taylor, Jm, Bruneau, Mahanty, al, A., MacLean, Bourque, Desroches, Fairey, Er, Edmunds, Js, Ramsdell, Vernoux, Jp, Fenner, Pj, Williamson, Ja, Ml, Poli, Ma, Dickey, Rw, Musser, Sm, Buckner, Ca, Carpenter, Lg, Sanner, Bm, Rawert, Henning, Zidek, Beadle, 1997. : Seafood-associated diseases and control in Canada

- The role of seafood in foodborne diseases in the United States of America

- Hazard analysis and critical control point systems applied to public health risks: the example of seafood

- Pacific ciguatoxin-1 associated with a large common-source outbreak of ciguatera in east Arnhem Land, Australia

- Ciguatera fish poisoning linked to the ingestion of barracuda in a Montreal restaurant--Quebec

- A cell-based assay for brevetoxins, saxitoxins, and ciguatoxins using a stably expressed c-fos-luciferase reporter gene

- Isolation and characterisation of Caribbean ciguatoxins from the horse- eye jack (Caranx latus)

- A Queensland family with ciguatera after eating coral trout

- Identification of Caribbean ciguatoxins as the cause of an outbreak of fish poisoning among U.S. soldiers in Haiti

- Ciguatera fish poisoning following travel to the tropics

- Ciguatera fish poisoning. Rev Sci Tech 16, 661-672.

Todd, E., 1985. Ciguatera poisoning in Canada, in: Anderson, D.M., White, A.W., Baden, D.G. (Eds.), Toxic Dinoflagellates. Elsevier, New York, NY, pp. 505-510.

Todd, E.C.D., 1993

1995. Estimated costs of paralytic shellfish, diarrhetic shellfish and ciguatera poisoning in Canada, in: Lassus, P., Arzul, G., Erard, E., Gentien, P., Marcaillou, C. (Eds.), Harmful Marine Algal Blooms. Lavoisier, Intercept Ltd., Nantes, France, pp. 831-834.

Todd, E.C.D., 1995. Estimated costs of paralytic shellfish, diarrhetic shellfish and ciguatera poisoning in Canada, in: Lassus, P., Arzul, G., Erard, E., Gentien, P., Marcaillou, C. (Eds.), Harmful Marine Algal Blooms. Lavoisier, Intercept Ltd., Nantes, France

Paris, pp. 831-834.

Todd, E.C.D., 1997. Seafood-associated diseases and control in Canada. REVUE-SCIENTIFIQUE-ET-TECHNIQUE-DE-L-OFFICE-INTERNATIONAL-DES-EPIZOOTIES 16, 661-672.

Tong, R.B., McDonald, F.E., Fang, X.K., Hardcastle, K.I., 2007. Biomimetic synthesis of fused bispyran: Lewis acid effects on oxacyclizations of polyepoxides. Synthesis-Stuttgart, 2337-2342.

Tongson, J., Chang, R.T., Suzuki, T., Hokama, Y., 1991. EVIDENCE FOR CIGUATOXIN (CTX) AND RELATED POLYETHER RECEPTORS IN THE ENDOTHELIAL TISSUE OF PIG SMALL-INTESTINE (PIR). Faseb J. 5, A514-A514.

Torikai, K., Oishi, T., Ujihara, S., Matsumori, N., Konoki, K., Murata, M., Aimoto, S., 2008. Design and synthesis of ladder-shaped tetracyclic, heptacyclic, and decacyclic ethers and evaluation of the interaction with transmembrane proteins. J. Am. Chem. Soc. 130, 10217-10226.

Torikai, K., Yari, H., Mori, M., Ujihara, S., Matsumori, N., Murata, M., Oishi, T., 2006. Design and synthesis of an artificial ladder-shaped polyether that interacts with glycophorin A. Bioorg. Med. Chem. Lett. 16, 6355-6359.

Torikai, K., Yari, H., Murata, M., Oishi, T., 2006. Synthesis of artificial ladder-shaped polyethers containing a 6/7 cis-fused ring system. Heterocycles 70, 161-+.

Tosteson, Tr, Manger, Rl, Leja, Ls, Lee, Sy, Hungerford, Jm, Hokama, Dickey, Rw, Granade, Hr, Lewis, Yasumoto, Wekell, Mm, Levine, Dz, Baden, Dg, Melinek, Sechet, Trainer, Vl, Schultz, Dr, Rein, Ks, Tomas, Cr, Delgado, Hale, DiNubile, Mj, Lechuga, D., Ch, Sierra, B., Ap, Habermehl, Gg, Krebs, Hc, Rasoanaivo, Ramialiharisoa, Ebesu, Js, Nagai, Lange, Wr, Glaziou, Legrand, Am, Ueno, Nagata, 1995. : The diversity and origins of toxins in ciguatera fish poisoning

- Detection of sodium channel toxins: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extracts

- Ciguatera: current concepts

- Modified immunoassays for polyether toxins: implications of biological matrixes, metabolic states, and epitope recognition

- The ciguatera poisoning syndrome from farm-raised salmon

- Documented case of ciguatera on the Mexican Pacific coast

- Food safety. Epidemiology of ciguatera poisoning

- Severe ciguatera poisoning in Madagascar: a case report

- The first reported case of human ciguatera possibly due to a farm- cultured salmon [published erratum appears in Toxicon 1995 May;33(5):711]

- Ciguatera fish poisoning

- The epidemiology of ciguatera fish poisoning

- [Natural poisons: (1) Algae toxins]. P R Health Sci J 14, 117-129.

Tosteson, T.R., 1995. The diversity and origins of toxins in ciguatera fish poisoning. P R Health Sci J 14, 117-129.

Tosteson, T.R., 2004. Caribbean ciguatera: a changing paradigm. Revista De Biologia Tropical 52, 109-113.

Trainer, Vl, Baden, Dg, Richards, Is, Kulkarni, Ap, Brooks, Sm, Pierce, Poli, Ma, Templeton, Cb, Thompson, Wl, Hewetson, Jf, Sheridan, Re, Adler, LeClaire, Rd, Franz, Dr, Mende, Tj, Szmant, Am, Edwards, Ra, Roszell, Le, Levine, Fujiki, Yamada, Ojika, Gjika, Hb, Van, Vunakis, Tomas, Cr, 1991. : An enzyme immunoassay for the detection of Florida red tide brevetoxins

- Florida red-tide toxins (brevetoxins) produce depolarization of airway smooth muscle

- Distribution and elimination of brevetoxin PbTx-3 in rats

- Brevetoxins: unique polyether dinoflagellate toxins

- The actions of a red tide toxin from Ptychodiscus brevis on single sodium channels in mammalian neuroblastoma cells

- Cardiorespiratory effects of brevetoxin (PbTx-2) in conscious, tethered rats

- Respiratory effects of brevetoxin and saxitoxin in awake guinea pigs

- Laboratory procedures for detoxification of equipment and waste contaminated with brevetoxins PbTx-2 and PbTx-3

- Brevetoxin binding: molecular pharmacology versus immunoassay

- Production of antibodies and development of a radioimmunoassay for okadaic acid

- Variations in major toxin composition for six clones of Ptychodiscus brevis

- Brevetoxins, unique activators of voltage-sensitive sodium channels, bind to specific sites in rat brain synaptosomes. Toxicon 29, 1387-1394.

Trevino, C.L., De la Vega-Beltran, J.L., Nishigaki, T., Felix, R., Darszon, A., 2006. Maitotoxin potently promotes Ca2+ influx in mouse spermatogenic cells and sperm, and induces the acrosome reaction. J. Cell. Physiol. 206, 449-456.

Tsai, W.L., Chen, H.M., Hsieh, C.H., Lin, W.F., Hwang, D.F., 2009. A potential methodology for differentiation of ciguatgoxin-carrying species of moray eel. Food Control 20, 575-579.

Tsai, W.L., Chen, H.-M., Hsieh, C.-H., Lin, W.-F., Hwang, D.-F., 2009. A potential methodology for differentiation of ciguatgoxin-carrying species of moray eel. Food Control 20, 575-579.

Tsuda, R., Kumanogoh, H., Umeda, M., Maekawa, S., 2008. Morphological analysis on the distribution of membrane lipids and a membrane protein, NAP-22, during neuronal development in vitro. Journal of Molecular Histology 39, 371-379.

Tsukano, C., Sasaki, M., 2006. Total synthesis and structure-activity relationship of a cytotoxic polycyclic ether gymnocin-A. J. Synth. Org. Chem. Jpn. 64, 808-818.

Tsumoto, K., Yokota, A., Tanaka, Y., Ui, M., Tsumuraya, T., Fujii, I., Kumagai, I., Nagumo, Y., Oguri, H., Inoue, M., Hirama, M., 2008. Critical contribution of aromatic rings to specific recognition of polyether rings - The case of ciguatoxin CTX3C-ABC and its specific antibody 1C49. J. Biol. Chem. 283, 12259-12266.

Tsumuraya, T., Fujii, I., Hirama, M., 2010. Production of monoclonal antibodies for sandwich immunoassay detection of Pacific ciguatoxins. Toxicon 56, 797-803.

Tsumuraya, T., Fujii, I., Hirama, M., 2014. Preparation of Anti-Ciguatoxin Monoclonal Antibodies Using Synthetic Haptens: Sandwich ELISA Detection of Ciguatoxins. J. AOAC Int. 97, 373-379.

Tsumuraya, T., Fujii, I., Inoue, M., Tatami, A., Miyazaki, K., Hirama, M., 2006. Production of monoclonal antibodies for sandwich immunoassay detection of ciguatoxin 51-hydroxyCTX3C. Toxicon 48, 287-294.

Tsumuraya, T., Takeuchi, K., Yamashita, S., Fujii, I., Hirama, M., 2012. Development of a monoclonal antibody against the left wing of ciguatoxin CTX1B: Thiol strategy and detection using a sandwich ELISA. Toxicon 60, 348-357.

Tsushima, R.G., 2000. Characterization of maitotoxin-activated nonselective cation channels in rat ventricular myocytes. Biophys. J. 78, 103A-103A.

Tucholski, J., Kuret, J., Johnson, G.V.W., 1999. Tau is modified by tissue transglutaminase in situ: Possible functional and metabolic effects of polyamination. J. Neurochem. 73, 1871-1880.

Twiner, M.J., Chidiac, P., Dixon, S.J., Trick, C.G., 2005. Extracellular organic compounds from the ichthyotoxic red tide alga Heterosigma akashiwo elevate cytosolic calcium and induce apoptosis in Sf9 cells. Harmful Algae 4, 789-800.

Ueda, H., Tamura, S., Fukushima, N., Takagi, H., 1986. PERTUSSIS TOXIN (IAP) ENHANCES MAITOTOXIN (A PUTATIVE CA-2+ CHANNEL AGONIST)-INDUCED CA-2+ ENTRY INTO SYNAPTOSOMES. Eur. J. Pharmacol. 122, 379-380.

Ueda, H., Tamura, S., Harada, H., Yasumoto, T., Takagi, H., 1986. THE MAITOTOXIN-EVOKED CA-2+ ENTRY INTO SYNAPTOSOMES IS ENHANCED BY CHOLERA-TOXIN. Neurosci. Lett. 67, 141-146.

Uehara, H., Oishi, T., Inoue, M., Shoji, M., Nagumo, Y., Kosaka, M., Le Brazidec, J.Y., Hirama, M., 2002. Convergent synthesis of the HIJKLM ring fragment of ciguatoxin CTX3C. Tetrahedron 58, 6493-6512.

Ui, M., Tanaka, Y., Tsumuraya, T., Fujii, I., Inoue, M., Hirama, M., Tsumoto, K., 2008. How protein recognizes ladder-like polycyclic ethers - Interactions between ciguatoxin (CTX3C) fragments and its specific antibody 10C9. J. Biol. Chem. 283, 8.

Ui, M., Tanaka, Y., Tsumuraya, T., Fujii, I., Inoue, M., Hirama, M., Tsumoto, K., 2011. Structural and energetic hot-spots for the interaction between a ladder-like polycyclic ether and the anti-ciguatoxin antibody 10C9Fab. Mol. Biosyst. 7, 793-798.

Ui, M., Tsumoto, K., 2009. Recognition mechanism for poly-cyclic ether toxin by anti-ciguatoxin antibody. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54, 1182-1189.

Ujihara, S., Oishi, T., Torikai, K., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Aimoto, S., 2008. Interaction of ladder-shaped polyethers with transmembrane alpha-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonance. Bioorg. Med. Chem. Lett. 18, 6115-6118.

Uradzinski, J., Wysok, B., Gomolka-Pawlicka, M., 2007. Biological and chemical hazards occurring in fish and fishery products. Pol. J. Vet. Sci. 10, 183-188.

Vale, C., Antelo, Á., Martín, V., 2015. Pharmacology of ciguatoxins, Phycotoxins. John Wiley & Sons, Ltd, pp. 23-48.

Valentine, J.C., McDonald, F.E., 2006. Biomimetic synthesis of trans,syn,trans-fused polycyclic ethers. Synlett, 1816-1828.

van, D.F.M., E.L., F., B.L., H., G.J., D., P.D., M., J.S., R., 1994. Development of rapid and sensitive high throughput pharmacological assays for marine phycotoxins. Nat. Toxins 2, 189-196.

Van Dolah, F.M., Roelke, D., Greene, R.M., 2000. Health and ecological impacts of harmful algal blooms: Risk assessment needs, 5th Symposium of EPA and the National-Health-and-Environmental-Effects-Laboratory, Res Triangle Pk, Nc, pp. 1329-1345.

Van Wagoner, R.M., Deeds, J.R., Satake, M., Ribeiro, A.A., Place, A.R., Wright, J.L.C., 2008. Isolation and characterization of karlotoxin 1, a new amphipathic toxin from Karlodinium veneficum. Tetrahedron Lett. 49, 6457-6461.

Van Wagoner, R.M., Deeds, J.R., Tatters, A.O., Place, A.R., Tomas, C.R., Wright, J.L.C., 2010. Structure and Relative Potency of Several Karlotoxins from Karlodinium veneficum. J. Nat. Prod. 73, 1360-1365.

VanDolah, F.M., Ramsdell, J.S., 1996. Maitotoxin, a calcium channel activator, inhibits cell cycle progression through the G1/S and G2/M transitions and prevents CDC2 kinase activation in GH(4)C(1) cells. J. Cell. Physiol. 166, 49-56.

Vasconcelos, V., Azevedo, J., Silva, M., Ramos, V., 2010. Effects of Marine Toxins on the Reproduction and Early Stages Development of Aquatic Organisms. Mar. Drugs 8, 59-79.

Veldhuis, J.D., Yoshida, K., Dubois, W., Fields, M.J., 1987. MAITOTOXIN STIMULATES STEROID AND PEPTIDE-HORMONE SECRETION BY SWINE LUTEAL TISSUE. American Journal of Physiology 252, E8-E12.

Venable, C.W., Miller, D.M., 1990. NMR of marine toxins, in: Miller, D.M. (Ed.), Ciguatera Seafood Toxins. CRC Press, Boca Raton; Ann Arbor; Boston, pp. 87-103.

Venable, C.W., Miller, D.M., 1991. NMR of marine toxins. CRC Press, Boca Raton; Ann Arbor; Boston.

Venant, A., Dazy, A.C., Diogene, G., Marano, F., 1995. Differential effects of maitotoxin on calcium entry and ciliary beating in the rabbit ciliated tracheal epithelium. Biology of the Cell 85, 197-205.

Venant, A., Dazy, A.C., Diogene, G., Metezeau, P., Marano, F., 1994. EFFECTS OF MAITOTOXIN ON CALCIUM-ENTRY AND PHOSPHOINOSITIDE BREAKDOWN IN THE RABBIT CILIATED TRACHEAL EPITHELIUM. Biology of the Cell 82, 195-202.

Verhoef, P.A., Estacion, M., Schilling, W.P., Kertesy, S., Dubyak, G.R., 2004. Maitotoxin-induced IL-1 beta release and membrane blebbing in murine macrophages. Faseb J. 18, A90-A90.

Verhoef, P.A., Kertesy, S.B., Estacion, M., Schilling, W.P., Dubyak, G.R., 2004. Maitotoxin induces biphasic interleukin-1 beta secretion and membrane blebbing in murine macrophages. Mol. Pharmacol. 66, 909-920.

Vernoux, J.P., 1991. Moyens d'investigation pour confirmer une intoxication de type ciguaterique, in: Fremy, J.M. (Ed.), Actes du Colloque sur les Biotoxines Marines. Centre National d'Etudes Veterinaires et Alimentaires, pp. 153-161.

Vernoux, J.P., Elandaloussi, S.A., 1986. HETEROGENEITY OF CIGUATOXINS EXTRACTED FROM FISH CAUGHT AT THE COAST OF THE FRENCH-ANTILLES. Biochimie 68, 287-291.

Vernoux, J.P., Lahlou, N., 1986. THE CHICK CIGUATOXIN BIOASSAY - A SYMPTOMATOLOGY AND SENSITIVITY ANALYSIS. Bulletin De La Societe De Pathologie Exotique 79, 140-146.

Vernoux, J.P., Lahlou, N., Elandaloussi, S.A., Riyeche, N., Magras, L.P., 1985. A STUDY OF THE DISTRIBUTION OF CIGUATOXIN IN INDIVIDUAL CARIBBEAN FISH. Acta Trop. 42, 225-233.

Vernoux, J.P., Lahlou, N., Magras, L.P., Greaux, J.B., 1985. CHICK FEEDING TEST - A SIMPLE SYSTEM TO DETECT CIGUATOXIN. Acta Trop. 42, 235-240.

Vernoux, J.P., Talha, F., 1989. FRACTIONATION AND PURIFICATION OF SOME MUSCULAR AND VISCERAL CIGUATOXINS EXTRACTED FROM CARIBBEAN FISH. Comp. Biochem. Physiol. B-Biochem. Mol. Biol. 94, 499-504.

Vernoux, J.-P., Lewis, R.J., 1997. Isolation and characterisation of Caribbean ciguatoxins from the horse-eye jack (Caranx latus). Toxicon 35, 889-900.

Vetter, I., Touska, F., Hess, A., Hinsbey, R., Sattler, S., Lampert, A., Sergejeva, M., Sharov, A., Collins, L.S., Eberhardt, M., Engel, M., Cabot, P.J., Wood, J.N., Vlachova, V., Reeh, P.W., Lewis, R.J., Zimmermann, K., 2012. Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO J 31, 3795-3808.

Vetter, I., Zimmermann, K., Lewis, R.J., 2014. Ciguatera Toxins, Seafood and Freshwater Toxins. CRC Press, pp. 925-950.

Vieira, A.S., Fiorante, P.F., Hough, T.L.S., Ferreira, F.P., Ludtke, D.S., Stefani, H.A., 2008. Nucleophilic Addition of Potassium Alkynyltrifluoroborates to D-Glucal Mediated by BF3 center dot OEt2: Highly Stereoselective Synthesis of alpha-C-glycosides. Org. Lett. 10, 5215-5218.

Vila, M., Garces, E., Maso, M., 2001. Potentially toxic epiphytic dinoflagellate assemblages on macroalgae in the NW Mediterranean. Aquat. Microb. Ecol. 26, 51-60.

Vilariño, N., Fonfría, E.S., Louzao, M.C., Botana, L.M., 2009. Use of biosensors as alternatives to current regulatory methods for marine biotoxins. Sensors 9, 9414-9443.

Villareal, T.A., Hanson, S., Qualia, S., Jester, E.L.E., Granade, H.R., Dickey, R.W., 2007. Petroleum production platforms as sites for the expansion of ciguatera in the northwestern Gulf of Mexico. Harmful Algae 6, 253-259.

Villareal, T.A., Morton, S.L., 2002. Use of cell-specific PAM-fluorometry to characterize host shading in the epiphytic dinoflagellate Gambierdiscus toxicus. Marine Ecology-Pubblicazioni Della Stazione Zoologica Di Napoli I 23, 127-140.

Vincenti, M., Irico, A., 2000. Characterization of marine toxins by means of liquid chromatography - Electrospray ionization - Mass spectrometry, in: Gianguzza, A., Pelizzetti, E., Sammartano, S. (Eds.), Chemical Processes in Marine Environments. Springer-Verlag Berlin, Berlin, pp. 321-338.

Vucic, S., Kiernan, M.C., 2008. Normal axonal ion channel function in large peripheral nerve fibers following chronic ciguatera sensitization. Muscle Nerve 37, 403-405.

Wachi, K.M., Hokama, Y., Haga, L.S., Shiraki, A., Takenaka, W.E., Bignami, G.S., Levine, L., 2000. Evidence for palytoxin as one of the sheep erythrocyte lytic in lytic factors in crude extracts of ciguateric and non-ciguateric reef fish tissue. Journal of Natural Toxins 9, 139-146.

Walls, T.J., 1992. METABOLIC AND TOXIC PERIPHERAL NEUROPATHIES INCLUDING DIABETES. Current Opinion in Neurology and Neurosurgery 5, 375-378.

Wang, D.Z., 2008. Neurotoxins from marine dinoflagellates: A brief review. Mar. Drugs 6, 349-371.

Wang, K.K.W., Hajimohammadreza, I., Raser, K.J., Nath, R., 1995. MAITOTOXIN INDUCES CALPAIN ACTIVATION IN SK-SY5Y NEUROBLASTOMA-CELLS AND FETAL CEREBROCORTICAL CULTURES. J. Cell. Biochem., 96-96.

Wang, K.K.W., Nath, R., Raser, K.J., Hajimohammadreza, I., 1996. Maitotoxin induces calpain activation in SH-SY5Y neuroblastoma cells and cerebrocortical cultures. Arch. Biochem. Biophys. 331, 208-214.

Wang, S.Y., Wang, G.K., 2003. Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins. Cell. Signal. 15, 151-159.

Wang, Y.J., Gregory, R.B., Barritt, G.J., 2002. Maintenance of the filamentous actin cytoskeleton is necessary for the activation of store-operated Ca2+ channels, but not other types of plasma-membrane Ca2+ channels, in rat hepatocytes. Biochem. J. 363, 117-126.

Wang, Y.S., Weiss, M.T., Yin, J.F., Frew, R., Tenn, C., Nelson, P.P., Vair, C., Sawyer, T.W., 2009. Role of the sodium hydrogen exchanger in maitotoxin-induced cell death in cultured rat cortical neurons. Toxicon 54, 95-102.

Watanabe, A., Ishida, Y., Honda, H., Kobayashi, M., Ohizumi, Y., 1993. CA-2+-DEPENDENT AGGREGATION OF RABBIT PLATELETS INDUCED BY MAITOTOXIN, A POTENT MARINE TOXIN, ISOLATED FROM A DINOFLAGELLATE. Br. J. Pharmacol. 109, 29-36.

Watters, M.R., 1995. ORGANIC NEUROTOXINS IN SEAFOODS. Clinical Neurology and Neurosurgery 97, 119-124.

Watters, M.R., 2009. Seafood neurotoxins ii: Other ingestible marine biotoxins-ciguatera, tetrodotoxin, cyanotoxins, Clinical Neurotoxicology: Syndromes, Substances, Environments, pp. 448-453.

Weber, W.M., Popp, C., Clauss, W., Van Driessche, W., 2000. Maitotoxin induces insertion of different ion channels into the Xenopus oocyte plasma membrane via Ca2+-stimulated exocytosis. Pflugers Arch. 439, 363-369.

Wellner, R.B., Patton, L.L., Holmes, M.J., Lewis, R.L., 1991. MAITOTOXIN (MTX) STIMULATES K+ TRANSPORT IN A HUMAN SALIVARY EPITHELIAL-CELL LINE (HSG-PA). Faseb J. 5, A821-A821.

Wellner, R.B., Patton, L.L., Pace, J.G., 1990. A COMPARISON OF THE ABILITIES OF MAITOTOXIN (MTX), CARBACHOL (CCH) AND 4-BR-A23187 (A23) TO INCREASE INTRACELLULAR FREE CALCIUM ( CA-2+ I) IN A HUMAN SUBMANDIBULAR EPITHELIAL-CELL LINE (HSG-PA). Abstracts of Papers of the American Chemical Society 200, 65-AGFD.

Wilcox, C.L., Hixon, M.A., 2015. False positive tests for ciguatera may derail efforts to control invasive lionfish. Environmental Biology of Fishes 98, 961-969.

Williamson, J., 1992. CURRENT CHALLENGES IN MARINE ENVENOMATION - AN OVERVIEW. Journal of Wilderness Medicine 3, 422-431.

Wisnoskey, B.J., Estacion, M., Schilling, W.P., 2004. Maitotoxin-induced cell death cascade in bovine aortic endothelial cells: divalent cation specificity and selectivity. Am. J. Physiol.-Cell Physiol. 287, C345-C356.

Wong, C.K., Hung, P., Lee, K.L.H., Kam, K.M., 2006. Untitled - Reply to letter to the editor. Toxicon 48, 470-472.

Wong, C.K., Hung, P., Lee, K.L.H., Kam, K.M., 2009. Solid-phase extraction clean-up of ciguatoxin-contaminated coral fish extracts for use in the mouse bioassay. Food Addit. Contam. Part A-Chem. 26, 236-247.

Wong, C.K., Hung, P., Lee, K.L.H., Mok, T., Chung, T., Kam, K.M., 2008. Features of Ciguatera Fish Poisoning Cases in Hong Kong 2004-2007. Biomed. Environ. Sci. 21, 521-527.

Wong, C.K., Kam, K.M., Lee, K.L.H., Hung, P., 2009. Solid-phase extraction clean-up of ciguatoxin-contaminated coral fish extracts for use in the mouse bioassay. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 26, 236-243.

Wong, C.-K., Hung, P., Lee, K.L.H., Kam, K.-M., 2005. Study of an outbreak of ciguatera fish poisoning in Hong Kong. Toxicon 46, 563-571.

Wong, C.-K., Hung, P., Lo, J.Y.C., 2014. Ciguatera fish poisoning in Hong Kong-A 10-year perspective on the class of ciguatoxins. Toxicon : official journal of the International Society on Toxinology 86, 96-106.

Woods, N.M., Dixon, C.J., Yasumoto, T., Cuthbertson, K.S.R., Cobbold, P.H., 1999. Maitotoxin-induced free Ca changes in single rat hepatocytes. Cell. Signal. 11, 805-811.

Woofter, R., Dechraoui, M.Y.B., Garthwaite, I., Towers, N.R., Gordon, C.J., Cordova, J., Ramsdell, J.S., 2003. Measurement of brevetoxin levels by radioimmunoassay of blood collection cards after acute, long-term, and low-dose exposure in mice. Environ. Health Perspect. 111, 1595-1600.

Worley, J.F., McIntyre, M.S., Spencer, B., Dukes, I.D., 1994. DEPLETION OF INTRACELLULAR CA2+ STORES ACTIVATES A MAITOTOXIN-SENSITIVE NONSELECTIVE CATIONIC CURRENT IN BETA-CELLS. J. Biol. Chem. 269, 32055-32058.

Wu, J.J., Mak, Y.L., Murphy, M.B., Lam, J.C., Chan, W.H., Wang, M., Chan, L.L., Lam, P.K., 2011. Validation of an accelerated solvent extraction liquid chromatography-tandem mass spectrometry method for Pacific ciguatoxin-1 in fish flesh and comparison with the mouse neuroblastoma assay. Anal Bioanal Chem 400, 3165-3175.

Wu, J.J., Mak, Y.L., Murphy, M.B., Lam, J.C.W., Chan, W.H., Wang, M., Chan, L.L., Lam, P.K.S., 2011. Validation of an accelerated solvent extraction liquid chromatography- tandem mass spectrometry method for Pacific ciguatoxin-1 in fish flesh and comparison with the mouse neuroblastoma assay. Anal. Bioanal. Chem. 400, 3165-3175.

Wu, J.J., Mak, Y.L., Murphy, M.B., Lam, J.C.W., Chan, W.H., Wang, M.F., Chan, L.L., Lam, P.K.S., 2011. Validation of an accelerated solvent extraction liquid chromatography-tandem mass spectrometry method for Pacific ciguatoxin-1 in fish flesh and comparison with the mouse neuroblastoma assay. Anal. Bioanal. Chem. 400, 3165-3175.

Xi, D., Kurtz, D.T., Ramsdell, J.S., 1996. Maitotoxin-elevated cytosolic free calcium in GH(4)C(1) rat pituitary cells nimodipine-sensitive and -insensitive mechanisms. Biochem. Pharmacol. 51, 759-769.

Xi, D., Vandolah, F.M., Ramsdell, J.S., 1992. MAITOTOXIN INDUCES A CALCIUM-DEPENDENT MEMBRANE DEPOLARIZATION IN GH4C1 PITUITARY-CELLS VIA ACTIVATION OF TYPE-L VOLTAGE-DEPENDENT CALCIUM CHANNELS. J. Biol. Chem. 267, 25025-25031.

Xie, H.Q., Johnson, G.V.W., 1998. Calcineurin inhibition prevents calpain-mediated proteolysis of tau in differentiated PC12 cells. J. Neurosci. Res. 53, 153-164.

Xie, Q.Z., Denton, R.W., Parker, K.A., 2008. A Relay Ring-Closing Metathesis Synthesis of Dihydrooxasilines, Precursors of (Z)-Iodo Olefins. Org. Lett. 10, 5345-5348.

Xu, Y., Richlen, M.L., Morton, S.L., Mak, Y.L., Chan, L.L., Tekiau, A., Anderson, D.M., 2014. Distribution, abundance and diversity of Gambierdiscus spp. from a ciguatera-endemic area in Marakei, Republic of Kiribati. Harmful Algae 34, 56-68.

Yadav, J.S., Raju, A.K., Sunitha, V., 2006. Highly stereoselective synthesis of C-(alkynyl)-pseudoglycals from delta-hydroxy-alpha,beta-unsaturated aldehydes. Tetrahedron Lett. 47, 5269-5272.

Yamamoto, K., Shrestha, J., Iida, T., Yoh, M., Honda, T., 1995. MOLECULAR EPIDEMIOLOGY OF VIBRIO-CHOLERAE O1 ISOLATED IN NEPAL BY SOUTHERN HYBRIDIZATION WITH A CHOLERA-TOXIN GENE PROBE. Journal of Diarrhoeal Diseases Research 13, 113-117.

Yamaoka, K., Inoue, M., Hirama, M., 2011. A study on mechanisms of toxic actions of ciguatoxins: existence of functional relationship between CTX3C and charged residues of voltage sensors in Na(v)1.4 sodium channel. Forensic Toxicol. 29, 125-131.

Yamaoka, K., Inoue, M., Ishihara, Y., Yamashita, S., Hirama, M., Seyama, I., 2009. A BIOTIN RESIDUE LINKED TO B-RING OF CIGUATOXIN BUT NOT TO M-RING SIGNIFICANTLY REDUCES THE BIOLOGICAL ACTIVITIES ON Na CHANNEL FUNCTION. J. Physiol. Sci. 59, 249-249.

Yamaoka, K., Inoue, M., Miyahara, H., Miyazaki, K., Hirama, M., 2004. A quantitative and comparative study of the effects of a synthetic ciguatoxin CTX3C on the kinetic properties of voltage-dependent sodium channels. Br. J. Pharmacol. 142, 879-889.

Yamaoka, K., Inoue, M., Miyazaki, K., Hirama, M., Kondo, C., Kinoshita, E., Miyoshi, H., Seyama, I., 2009. Synthetic Ciguatoxins Selectively Activate Na(v)1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells. J. Biol. Chem. 284, 7594-7602.

Yamaoka, K., Inoue, M., Miyazaki, K., Hirama, M., Seyama, I., 2005. Mutation of the site-2 toxin binding site modifies the effects of ciguatoxin on Na(v)1.4 Na channels, 49th Annual Meeting of the Biopysical-Society, Long Beach, CA, pp. 97A-97A.

Yamashita, S., Iijima, N., Shida, T., Hirama, M., 2010. STEREOSELECTIVE SYNTHESIS OF CARIBBEAN CIGUATOXIN M-RING USING 2+2 PHOTOCYCLIZATION. Heterocycles 82, 761-774.

Yamashita, S., Uematsu, R., Hirama, M., 2011. Stereoselective synthesis of the left wing of Caribbean ciguatoxin. Tetrahedron 67, 6616-6626.

Yasumoto, T., 2001. The chemistry and biological function of natural marine toxins. Chem. Rec. 1, 228-242.

Yasumoto, T., 2005. Chemistry, etiology, and food chain dynamics of marine toxins. Proc. Jpn. Acad. Ser. B-Phys. Biol. Sci. 81, 43-51.

Yasumoto, T., Fukui, M., Sasaki, K., Sugiyama, K., 1993. DETERMINATIONS OF MARINE TOXINS IN FOODS, Symposium on Analytical Methods for Seafood Toxins, at the 107th AOAC International Annual Meeting, Washington, Dc, pp. 574-582.

Yasumoto, T., Hashimoto, Y., Bagnis, R., Randall, J.E., Banner, A.H., 1971. Toxicity of the surgeonfishes. Bull Jap Soc Sci Fish 37, 724-734.

Yasumoto, T., Igarashi, T., Legrand, A.M., Cruchet, P., Chinain, M., Fujita, T., Naoki, H., 2000. Structural elucidation of ciguatoxin congeners by fast-atom bombardment tandem mass spectroscopy. J. Am. Chem. Soc. 122, 4988-4989.

Yasumoto, T., Kanno, K., 1976. TOXICITY STUDIES ON MARINE SNAILS .5. OCCURRENCE OF TOXINS RESEMBLING CIGUATOXIN, SCARITOXIN, AND MAITOTOXIN IN A TURBAN SHELL. Bulletin of the Japanese Society of Scientific Fisheries 42, 1399-1404.

Yasumoto, T., Murata, M., 1990. : Polyether toxins involved in seafood poisoning. (In `Marine toxins - origin, structure and molecular physiology' [see FSTA (1992) 24 5C73].). : ACS Symposium Series 418, 120-132.

Yasumoto, T., Murata, M., Satake, M., Nagai, H., 1993. BIOACTIVE POLYETHERS FROM MARINE DINOFLAGELLATES. Gazzetta Chimica Italiana 123, 367-370.

Yasumoto, T., Nakajima, I., Bagnis, R., Adachi, R., 1977. Finding of a dinoflagellate as a likely culprit of ciguatera. Bull. Jap. Soc. Sci. Fish. 43, 1021-1026.

Yasumoto, T., Nakajima, I., Oshima, Y., Bagnis, R., 1979. A new toxic dinoflagellate found in association with ciguatera, in: Taylor, D.L., Seliger, H.H. (Eds.), Toxic Dinoflagellate Blooms. Elsevier North Holland, Inc., Amsterdam, pp. 65-70.

Yasumoto, T., Satake, M., 1996. Chemistry, etiology and determination methods of ciguatera toxins. Journal of Toxicology-Toxin Reviews 15, 91-107.

Yasumoto, T., Satake, M., Fukui, M., Nagai, H., Murata, M., Legrand, A.-M., 1993. A turning point in the ciguatera study, in: Smayda, T.J., Shimizu, Y. (Eds.), Toxic Phytoplankton Blooms in the Sea. Elsevier Sci. Publ. B.V., pp. 455-460.

Yasumoto, T., Satake, M., Sugiyama, K., Ishida, S., Murata, M., Naoki, H., 1995. Maitotoxin and other ciguatera toxins: From structures to determination. Harmful Marine Algal Blooms 377-382.

Yasumoto, T., Seino, N., Murakami, Y., Murata, M., 1987. Toxins produced by benthic dinoflagellates. Biol. Bull. 172, 128-131.

Yer, K., Rainier, J.D., 2007. Olefinic ester and diene ring-closing metathesis using a reduced titanium alkylidene. J. Am. Chem. Soc. 129, 12604-+.

Yi, S.J., Kim, K.H., Choi, H.J., Yoo, J.O., Jung, H.I., Han, J.A., Kim, Y.M., Suh, I.B., Ha, K.S., 2006. Ca2+ -dependent generation of intracellular reactive oxygen species mediates maitotoxin-induced cellular responses in human umbilical vein endothelial cells. Mol. Cells 21, 121-128.

Yogi, K., Oshiro, N., Inafuku, Y., Hirama, M., Yasumoto, T., 2011. Detailed LC-MS/MS Analysis of Ciguatoxins Revealing Distinct Regional and Species Characteristics in Fish and Causative Alga from the Pacific. Anal. Chem. 83, 8886-8891.

Yogi, K., Oshiro, N., Matsuda, S., Sakugawa, S., Matsuo, T., Yasumoto, T., 2013. Toxin profiles in fish implicated in ciguatera fish poisoning in Amami and Kakeroma Islands, Kagoshima prefecture, Japan. J. Food Hyg. Soc. Jpn. 54, 385-391.

Yogi, K., Sakugawa, S., Oshiro, N., Ikehara, T., Sugiyama, K., Yasumoto, T., 2014. Determination of Toxins Involved in Ciguatera Fish Poisoning in the Pacific by LC/MS. J AOAC Int 97, 398-403.

Yokoyama, A., Murata, M., Oshima, Y., Iwashita, T., Yasumoto, T., 1988. SOME CHEMICAL-PROPERTIES OF MAITOTOXIN, A PUTATIVE CALCIUM-CHANNEL AGONIST ISOLATED FROM A MARINE DINOFLAGELLATE. J. Biochem. 104, 184-187.

Yoo, J.O., Yi, S.J., Choi, H.J., Kim, W.J., Kim, Y.M., Han, J.A., Ha, K.S., 2005. Regulation of tissue transglutaminase by prolonged increase of intracellular Ca2+, but not by initial peak of transient Ca2+ increase. Biochem. Biophys. Res. Commun. 337, 655-662.

Yoon, S.Y., Choi, H.I., Choi, J.E., Sul, C.A., Choi, J.M., Kim, D.H., 2007. Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron. Biochem. Biophys. Res. Commun. 363, 811-816.

Yoshii, M., Tsunoo, A., Kuroda, Y., Wu, C.H., Narahashi, T., 1987. MAITOTOXIN-INDUCED MEMBRANE CURRENT IN NEUROBLASTOMA-CELLS. Brain Res. 424, 119-125.

Yoshikawa, K., Inoue, M., Hirama, M., 2007. Synthesis of the LMN-ring fragment of the Caribbean ciguatoxin C-CTX-1. Tetrahedron Lett. 48, 2177-2180.

Yuan, J.-h., Yang, H., Tang, H.-w., Huang, W., Xu, X.-y., Liu, J.-j., Ke, Y.-b., Cheng, J.-q., Zhuang, Z.-x., 2011. A cell-based detection of ciguatoxin using sodium fluorescence probe. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 31, 653-655.

Zaccaroni, A., Scaravelli, D., 2007. Toxicity of sea algal toxins to humans and animals, in: Evangelista, V., Barsanti, L., Frassanito, A.M., Passarelli, V., Gualtieri, P. (Eds.), Conference on NATO-Advamced-Study-Institute on Sensor Systems for Biological Threats - Algal Toxins Case. Springer, Pisa, ITALY, pp. 91-158.

Zhang, J.F., Randall, A.D., Ellinor, P.T., Horne, W.A., Sather, W.A., Tanabe, T., Schwarz, T.L., Tsien, R.W., 1993. DISTINCTIVE PHARMACOLOGY AND KINETICS OF CLONED NEURONAL CA2+ CHANNELS AND THEIR POSSIBLE COUNTERPARTS IN MAMMALIAN CNS NEURONS. Neuropharmacology 32, 1075-1088.

Zhang, J.W., Guttmann, R.P., Johnson, G.V.W., 1998. Tissue transglutaminase is an in situ substrate of calpain: Regulation of activity. J. Neurochem. 71, 240-247.

Zhang, J.W., Lesort, M., Guttmann, R.P., Johnson, G.V.W., 1998. Modulation of the in situ activity of tissue transglutaminase by calcium and GTP. J. Biol. Chem. 273, 2288-2295.

Zhang, X., Cao, B., Wang, J., Liu, J., Tung, V.O.V., Lam, P.K.S., Chan, L.L., Li, Y., 2013. Neurotoxicity and Reactive Astrogliosis in the Anterior Cingulate Cortex in Acute Ciguatera Poisoning. Neuromolecular Medicine 15, 310-323.

Zhang, Y., Rainier, J.D., 2009. Two-Directional Olefinic-Ester Ring-Closing Metathesis using Reduced Ti Alkylidenes. A Rapid Entry into Polycyclic Ether Skeletons. Org. Lett. 11, 237-239.

Zhang, Z., Liu, Y., Zhang, C., Luan, W., 2015. Horseradish peroxidase and antibody labeled gold nanoparticle probe for amplified immunoassay of ciguatoxin in fish samples based on capillary electrophoresis with electrochemical detection. Toxicon 96, 88-95.

Zhang, Z.Q., Larner, S.F., Liu, M.C., Zheng, W.R., Hayes, R.L., Wang, K.K.W., 2009. Multiple alphaII-spectrin breakdown products distinguish calpain and caspase dominated necrotic and apoptotic cell death pathways. Apoptosis 14, 1289-1298.

Zhang, Z.Q., Ottens, A.K., Sadasivan, S., Kobeissy, F.H., Fang, T., Hayes, R.L., Wang, K.K.W., 2007. Calpain-mediated collapsin response mediator protein-1,-2, and-4 proteolysis after neurotoxic and traumatic brain injury. Journal of Neurotrauma 24, 460-472.

Zhao, X., Pike, B.R., Newcomb, J.K., Wang, K.K.W., Posmantur, R.M., Hayes, R.L., 1999. Maitotoxin induces calpain but not caspase-3 activation and necrotic cell death in primary septo-hippocampal cultures. Neurochemical Research 24, 371-382.

Zhao, X.R., Bausano, B., Pike, B.R., Newcomb-Fernandez, J.K., Wang, K.K.W., Shohami, E., Ringger, N.C., DeFord, S.M., Anderson, D.K., Hayes, R.L., 2001. TNF-alpha stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures. J. Neurosci. Res. 64, 121-131.

Zhao, X.R., Newcomb, J.K., Pike, B.R., Wang, K.K.W., d'Avella, D., Hayes, R.L., 2000. Novel characteristics of glutamate-induced cell death in primary septohippocampal cultures: Relationship to calpain and caspase-3 protease activation. Journal of Cerebral Blood Flow and Metabolism 20, 550-562.

Zheng, J., Zhao, B., Yan, H., Zhang, K., Zhang, D., Zhao, S., 2011. Molecular Docking and Molecular Dynamics Simulation Studies of Toxicity Mechanism of Ciguatoxin. Acta Chimica Sinica 69, 2026-2030.

Zheng, J., Zhao, B., Yan, H.P., Zhang, K., Zhang, D.P., Zhao, S.Q., 2011. Molecular Docking and Molecular Dynamics Simulation Studies of Toxicity Mechanism of Ciguatoxin. Acta Chimica Sinica 69, 2026-2030.

Zheng, W.J., DeMattei, J.A., Wu, J.P., Duan, J.J.W., Cook, L.R., Oinuma, H., Kishi, Y., 1996. Complete relative stereochemistry of maitotoxin. J. Am. Chem. Soc. 118, 7946-7968.

Zhu, L.Y., Song, L.Y., Tong, R.B., 2012. Diastereoselective Reductive Ring Expansion of Spiroketal Dihydropyranones to cis-Fused Bicyclic Ethers. Org. Lett. 14, 5892-5895.

Zimmermann, K., Deuis, J.R., Inserra, M.C., Collins, L.S., Namer, B., Cabot, P.J., Reeh, P.W., Lewis, R.J., Vetter, I., 2013. Analgesic treatment of ciguatoxin-induced cold allodynia. Pain 154, 1999-2006.

Zimmermann, K., Eisenblaetter, A., Vetter, I., Ebbecke, M., Friedemann, M., Desel, H., 2015. Poisoning by Tropical Fish: Ciguatera-Epidemic in Germany. Deutsche Medizinische Wochenschrift 140, 125-U159.

Zimmermann, K., Eisenblatter, A., Vetter, I., Ebbecke, M., Friedemann, M., Desel, H., 2015. [Imported tropical fish causes ciguatera fish poisoning in Germany]. Dtsch Med Wochenschr 140, 125-130.

Zimmermann, K., Eisenblatter, A., Vetter, I., Ebbecke, M., Friedemann, M., Desel, H., 2015. Poisoning by Tropical Fish: Ciguatera-Epidemic in Germany. Deutsche Medizinische Wochenschrift 140, 125-U159.

Zlotnick, B.A., Hintz, S., Park, D.L., Auerbach, P.S., 1995. CIGUATERA POISONING AFTER INGESTION OF IMPORTED JELLYFISH - DIAGNOSTIC APPLICATION OF SERUM IMMUNOASSAY. Wildern. Environ. Med. 6, 288-294.